Professional Education


  • Doctor of Science, Northwest China University (2018)
  • Bachelor of Science, Northwest China University (2013)

All Publications


  • Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones. Organic letters Trost, B. M., Nagaraju, A., Wang, F., Zuo, Z., Xu, J., Hull, K. L. 2019

    Abstract

    A palladium-catalyzed decarboxylative asymmetric allylic alkylation (Pd-DAAA) of benzo-fused and non-benzo-fused delta-valerolactams is disclosed. This methodology gives access to chiral lactams bearing C3-quaternary stereocenters, which are central to many natural products and biologically active compounds. The reaction proceeds via palladium-catalyzed ionization of an allyl ester, followed by carbon dioxide extrusion and recombination of the electrophilic Pd-pi-allyl complex with the in situ generated lactam enolate. This final step converts racemic allylic ester starting materials into enantiomerically enriched substituted lactams with high yield and enantiomeric excess.

    View details for PubMedID 30834753