Professional Education


  • Doctor of Science, Northwest China University (2018)
  • Bachelor of Science, Northwest China University (2013)

All Publications


  • Highly Regio-, Diastereo-, and Enantioselective Synthesis of Tetrahydroazepines and Benzo[b]oxepines via Palladium-Catalyzed [4+3] Cycloaddition Reactions. Angewandte Chemie (International ed. in English) Trost, B. M., Zuo, Z. 2019

    Abstract

    A novel Pd(0)-catalyzed asymmetric [4+3] annulation reaction of two readily accessible starting materials has been developed for building seven-membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo-, regio-, diastereo- and enantioselectivtities, leading to valuable tetrahydroazepines and benzo[b]oxepines.

    View details for DOI 10.1002/anie.201911537

    View details for PubMedID 31610098

  • Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones ORGANIC LETTERS Trost, B. M., Nagaraju, A., Wang, F., Zuo, Z., Xu, J., Hull, K. L. 2019; 21 (6): 1784–88
  • Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Dihydroquinolinones. Organic letters Trost, B. M., Nagaraju, A., Wang, F., Zuo, Z., Xu, J., Hull, K. L. 2019

    Abstract

    A palladium-catalyzed decarboxylative asymmetric allylic alkylation (Pd-DAAA) of benzo-fused and non-benzo-fused delta-valerolactams is disclosed. This methodology gives access to chiral lactams bearing C3-quaternary stereocenters, which are central to many natural products and biologically active compounds. The reaction proceeds via palladium-catalyzed ionization of an allyl ester, followed by carbon dioxide extrusion and recombination of the electrophilic Pd-pi-allyl complex with the in situ generated lactam enolate. This final step converts racemic allylic ester starting materials into enantiomerically enriched substituted lactams with high yield and enantiomeric excess.

    View details for PubMedID 30834753