Doctor of Science, Lanzhou University (2018)
Bachelor (Undeclared), Zhengzhou University (2009)
Elaborating Complex Heteroaryl Containing Cycles via Enantioselective Palladium-Catalyzed Cycloadditions.
Angewandte Chemie (International ed. in English)
A general method for asymmetric synthesis of heteroaryl containing cycles via palladium-catalyzed cyclization is reported. Most classes of nitrogen-containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivatives of nucleobases are compatible substrates, offering various heteroaryl-substituted cyclopentane, pyrrolidine, furanidine and bicyclo [4, 3, 1] decadiene derivatives with good to excellent enantioselectivity and diastereoselectivity.
View details for DOI 10.1002/anie.201910061
View details for PubMedID 31483926
Enantioselective Divergent Syntheses of (+)-Bulleyanaline and Related Isoquinoline Alkaloids from the Genus Corydalis.
Journal of the American Chemical Society
The isoquinoline alkaloids isolated from the genus Corydalis possess potent and diverse biological activities. Herein, a concise, divergent, and enantioselective route to access these natural products is disclosed. Key transformations of our approach include a challenging Zn-ProPhenol-catalyzed asymmetric Mannich reaction to build a quaternary stereogenic center and a rapid cationic Au-catalyzed cycloisomerization to the common structural skeleton of these natural products. Subsequent late-stage oxidations and modifications allow efficient access to the targeted alkaloids. Overall, seven natural products have been successfully synthesized in 6 to 10 steps from readily available starting materials, including (+)-corynoline, (+)-anhydrocorynoline, (+)-12-hydroxycorynoline, (+)-12-hydroxycorynoloxine, (+)-corynoloxine, (+)-6-acetonylcorynoline, and (+)-bulleyanaline.
View details for DOI 10.1021/jacs.9b08441
View details for PubMedID 31525040