Professional Education

  • Doctor of Science, Lanzhou University (2018)
  • Bachelor (Undeclared), Zhengzhou University (2009)

All Publications

  • Elaborating Complex Heteroaryl Containing Cycles via Enantioselective Palladium-Catalyzed Cycloadditions. Angewandte Chemie (International ed. in English) Trost, B. M., Jiao, Z., Hung, C. J. 2019


    A general method for asymmetric synthesis of heteroaryl containing cycles via palladium-catalyzed cyclization is reported. Most classes of nitrogen-containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivatives of nucleobases are compatible substrates, offering various heteroaryl-substituted cyclopentane, pyrrolidine, furanidine and bicyclo [4, 3, 1] decadiene derivatives with good to excellent enantioselectivity and diastereoselectivity.

    View details for DOI 10.1002/anie.201910061

    View details for PubMedID 31483926

  • Enantioselective Divergent Syntheses of (+)-Bulleyanaline and Related Isoquinoline Alkaloids from the Genus Corydalis. Journal of the American Chemical Society Trost, B. M., Hung, C. J., Jiao, Z. 2019


    The isoquinoline alkaloids isolated from the genus Corydalis possess potent and diverse biological activities. Herein, a concise, divergent, and enantioselective route to access these natural products is disclosed. Key transformations of our approach include a challenging Zn-ProPhenol-catalyzed asymmetric Mannich reaction to build a quaternary stereogenic center and a rapid cationic Au-catalyzed cycloisomerization to the common structural skeleton of these natural products. Subsequent late-stage oxidations and modifications allow efficient access to the targeted alkaloids. Overall, seven natural products have been successfully synthesized in 6 to 10 steps from readily available starting materials, including (+)-corynoline, (+)-anhydrocorynoline, (+)-12-hydroxycorynoline, (+)-12-hydroxycorynoloxine, (+)-corynoloxine, (+)-6-acetonylcorynoline, and (+)-bulleyanaline.

    View details for DOI 10.1021/jacs.9b08441

    View details for PubMedID 31525040