Professional Education


  • Doctor of Science, Lanzhou University (2018)
  • Bachelor (Undeclared), Zhengzhou University (2009)

All Publications


  • Asymmetric Three-Component Heck/Amination of Nonconjugated Cyclodienes. Angewandte Chemie (International ed. in English) Zhou, J. S., Zhu, D., Chi, Y. R., Jiao, Z., Goncalves, T. P., Huang, K. 2020

    Abstract

    Asymmetric Heck/amination of nonconjugated cyclodienes proceeds to give substituted cyclohexenylamines in good enantioselectivity and exclusive trans configurations. Substituted chiral cyclohexylamines are becoming increasingly important in drug discovery. Suitable amines in this reaction include primary and secondary anilines, indoline and benzylamines. A weakly-donating diphosphite, Kelliphite forms a deep unsymmetrical pocket, which is essential for stereoselective anti-attack of external amines.

    View details for DOI 10.1002/anie.201915864

    View details for PubMedID 31965664

  • Elaborating Complex Heteroaryl Containing Cycles via Enantioselective Palladium-Catalyzed Cycloadditions. Angewandte Chemie (International ed. in English) Trost, B. M., Jiao, Z., Hung, C. J. 2019

    Abstract

    A general method for asymmetric synthesis of heteroaryl containing cycles via palladium-catalyzed cyclization is reported. Most classes of nitrogen-containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivatives of nucleobases are compatible substrates, offering various heteroaryl-substituted cyclopentane, pyrrolidine, furanidine and bicyclo [4, 3, 1] decadiene derivatives with good to excellent enantioselectivity and diastereoselectivity.

    View details for DOI 10.1002/anie.201910061

    View details for PubMedID 31483926

  • Enantioselective Divergent Syntheses of (+)-Bulleyanaline and Related Isoquinoline Alkaloids from the Genus Corydalis. Journal of the American Chemical Society Trost, B. M., Hung, C. J., Jiao, Z. 2019

    Abstract

    The isoquinoline alkaloids isolated from the genus Corydalis possess potent and diverse biological activities. Herein, a concise, divergent, and enantioselective route to access these natural products is disclosed. Key transformations of our approach include a challenging Zn-ProPhenol-catalyzed asymmetric Mannich reaction to build a quaternary stereogenic center and a rapid cationic Au-catalyzed cycloisomerization to the common structural skeleton of these natural products. Subsequent late-stage oxidations and modifications allow efficient access to the targeted alkaloids. Overall, seven natural products have been successfully synthesized in 6 to 10 steps from readily available starting materials, including (+)-corynoline, (+)-anhydrocorynoline, (+)-12-hydroxycorynoline, (+)-12-hydroxycorynoloxine, (+)-corynoloxine, (+)-6-acetonylcorynoline, and (+)-bulleyanaline.

    View details for DOI 10.1021/jacs.9b08441

    View details for PubMedID 31525040