Institute Affiliations

Professional Education

  • Bachelor of Science, Nanyang Technological University (2018)
  • Doctor of Philosophy, National University Of Singapore (2022)
  • PhD, National University of Singapore, Yong Loo Lin School of Medicine (2022)
  • BSc, Nanyang Technological University, School of Biological Sciences (2018)

Stanford Advisors

Contact

  • Academic
    University - Scholar Department: Pediatrics Position: Postdoctoral Scholar

Additional Info

All Publications

  • Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development. Science immunology Mohammed, A., Wang, W., Arreola, M., Solomon, B. D., Slepicka, P. F., Hubka, K. M., Nguyen, H. D., Zheng, Z., Chavez, M. G., Yeh, C. Y., Kim, D. K., Ma, M. R., Martin, E., Li, L., Pasca, A. M., Winn, V. D., Gifford, C. A., Kedlian, V. R., Park, J. E., Khatri, P., Hollander, G. A., Roncarolo, M. G., Sebastiano, V., Teichmann, S. A., Gentles, A. J., Weinacht, K. G. 2025; 10 (107): eado4720

    Abstract

    Advances in genomics have redefined our understanding of thymic epithelial heterogeneity and architecture, yet signals driving thymic epithelial differentiation remain incompletely understood. Here, we elucidated pathways instructing human thymic epithelial cell development in the context of other anterior foregut-derived organs. Activation of interferon response gene regulatory networks distinguished epithelial cells of the thymus from those of other anterior foregut-derived organs. Thymic cortex and medulla epithelia displayed distinctive interferon-responsive signatures defined by lineage-specific chromatin accessibility. We explored the effects of type I and II interferons on thymic epithelial progenitor differentiation from induced pluripotent stem cells. Type II interferon was essential for expressing proteasome and antigen-presenting molecules, whereas type I or II interferons were essential for inducing different cytokines in thymic epithelial progenitor cells. Our findings suggest that interferons are critical to cortical and medullary thymic epithelial cell differentiation.

    View details for DOI 10.1126/sciimmunol.ado4720

    View details for PubMedID 40315299

  • Accelerating Immune Reconstitution in HSCT Patients through iPSC-Derived Thymic Epithelial Cells Mohammed, A., Hanh Dan Nguyen, Hubka, K., Wang, W., Slepicka, P., Solomon, B., Arreola, M., Zheng, Z., Gentles, A., Weinacht, K. G. AMER SOC HEMATOLOGY. 2023

    View details for DOI 10.1182/blood-2023-186901

    View details for Web of Science ID 001159306701217

https://orcid.org/0009-0008-9113-6646