School of Medicine
Showing 271-280 of 1,246 Results
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Maurice L. Druzin
Professor of Obstetrics and Gynecology (Maternal Fetal Medicine and Obstetrics), Emeritus
Current Research and Scholarly InterestsAntepartum and intrapartum fetal monitoring Prenatal diagnosis Medical complications of pregnancy, particularly: SLE, hypertension, diabetes, malignancy A.
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Justin Du Bois
Henry Dreyfus Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
BioThe Du Bois lab is heavily invested in exploring voltage-gated ion channel function and physiology and the underlying role of specific channels in human pathologies, particularly nociception, epilepsy, and neurodevelopmental disorders. With expertise in chemical synthesis, we have access to a collection of exceptional natural products—tetrodotoxin, saxitoxin, gonyautoxin, batrachotoxin, veratridine, antillatoxin, to name a few—that act as selective modulators of sodium ion channels (NaVs). In addition, we have developed novel molecules as inhibitors and agonists of specific voltage-gated chloride (ClCs) and calcium (CaVs) channel isoforms. As a lab, we are uniquely positioned to advance high-precision chemical tools to interrogate underlying biochemical mechanisms of electrogenesis. Our work in this arena is guided by a number of questions related to the basic functioning of voltage-gated channels in neuronal cells and glia that include: 1) what is the rate at which channels are being made and degraded and is the rate of channel turnover context dependent (i.e., is protein turnover affected by increased neuronal activity, nerve cell damage, etc.); 2) to what extent is channel expression and cellular distribution affected by external factors (pH, inflammatory modulators, injury); 3) how do post-translational protein modifications influence channel function and how are such modifications altered in response to external factors; 4) how do neighboring glia influence channel expression and ion gating. Answers to these types of questions will provide a deeper understanding of the molecular mechanisms by which neuronal cells and tissue respond to external stimuli, stress, and injury. We benefit from the strong interest of others in our work and multiple collaborators at Stanford and at other institutions.
Ion channel function and physiology. We wish to understand the role of individual subtypes of voltage-gated sodium, chloride, and calcium channels in neuronal signaling and how structural changes (i.e., point mutations, post-translational modifications, partner proteins) alter channel function. Our interests include the design, development, and application of chemogenetic technologies for targeting individual channel subtypes and allosteric modulators of select channel isoforms. Our work aims to inform efforts in translational research, as voltage-gated ion channel dysregulation and malfunction underlie a wide range of human diseases and disorders.
Natural products synthesis. We are interested in developing efficient and flexible synthetic routes to natural products that serve as ‘lead’ compounds for advancing high precision pharmacological tools. Most of the targets we are interested in obtaining are not available in sufficient quantities from natural sources, thus necessitating de novo preparation. To streamline the assembly process of these complex molecules, we are challenged to develop, in parallel, new tactics and chemical methods that facilitate C–C, C–N, and C–O bond formation.
Toxin ‘sponge’ proteins. A longstanding collaboration with the Minor lab at UCSF has focused on understanding how certain organisms that ingest dietary toxins such as saxitoxin, tetrodotoxin, and batrachotoxin survive their poisonous effects. This work has resulted in the elucidation of the structures of novel paralytic shellfish-binding proteins (so-called saxiphilins) and the toxin ‘binding code’. Studies are ongoing to integrate saxiphilins into a diagnostic device for measuring toxin concentrations in shellfish and to advance an engineered toxin-binding protein as a countermeasure for paralytic shellfish poisoning. -
Dawn Duane
Clinical Professor, Pediatric Neurology
Clinical Professor (By courtesy), PediatricsCurrent Research and Scholarly InterestsI am a general pediatric neurologist. My interest is in clinical diagnosis and treatment of common neurologic diseases in pediatric patients and teaching feature doctors, neurologists and pediatric neurologists about pediatric neurology.
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Anne Dubin
Endowed Professor of Pediatric Cardiology
Current Research and Scholarly InterestsArrhythmia management in pediatric heart failure, especially resynchronization therapy in congenital heart disease,Radio frequency catheter ablation of pediatric arrhythmias,
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Laramie Duncan
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
Current Research and Scholarly InterestsOur work is at the intersection of statistical genetics, psychiatry, and neuroscience. We use massive datasets and primarily computational approaches to identify mechanisms contributing to mental health problems like schizophrenia and depression. The overall goal of the lab is to discover fundamental information about psychiatric disorders, and ultimately to build more effective approaches to classification, prevention, and treatment.
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Caroline Duncombe
Postdoctoral Scholar, Immunity Transplant Infection
BioDr. Caroline Duncombe is a Postdoctoral Scholar in the Institute for Immunity, Transplantation, and Infection at Stanford University. Her research broadly explores how sex-based differences influence immune responses to infectious diseases. She applies systems-level approaches to investigate molecular and cellular mechanisms underlying immune variation, with the goal of informing more equitable and effective interventions.
Dr. Duncombe earned her PhD in Pathobiology from the University of Washington, where she pursued interdisciplinary research integrating systems biology, immunology, epidemiology, endocrinology, and parasitology. Her work has contributed to a deeper understanding of how sex and sex hormones shape host-pathogen interactions and vaccine responses.
In addition to her academic research, Dr. Duncombe is committed to science communication. She has produced science-focused comedy shows for over four years, using storytelling and humor to make complex scientific ideas more accessible.
Personal Website: carolinethescientist.com
LinkedIn Profile: linkedin.com/in/caroline-duncombe-phd-4ba11a124 -
Alexander Dunn
Professor of Chemical Engineering
Current Research and Scholarly InterestsMy lab is deeply interested in uncovering the physical principles that underlie the construction of complex, multicellular animal life.
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James Dunn
Professor of Surgery (Pediatric Surgery)
Current Research and Scholarly InterestsIntestinal lengthening for short bowel syndrome
Intestinal stem cell therapy for intestinal failure
Skin derived precursor cell therapy for enteric neuromuscular dysfunction
Intestinal tissue engineering
