School of Medicine
Showing 321-330 of 1,229 Results
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Michael Fischbach
Liu (Liao) Family Professor
Current Research and Scholarly InterestsThe microbiome carries out extraordinary feats of biology: it produces hundreds of molecules, many of which impact host physiology; modulates immune function potently and specifically; self-organizes biogeographically; and exhibits profound stability in the face of perturbations. Our lab studies the mechanisms of microbiome-host interactions. Our approach is based on two technologies we recently developed: a complex (119-member) defined gut community that serves as an analytically manageable but biologically relevant system for experimentation, and new genetic systems for common species from the microbiome. Using these systems, we investigate mechanisms at the community level and the strain level.
1) Community-level mechanisms. A typical gut microbiome consists of 200-250 bacterial species that span >6 orders of magnitude in relative abundance. As a system, these bacteria carry out extraordinary feats of metabolite consumption and production, elicit a variety of specific immune cell populations, self-organize geographically and metabolically, and exhibit profound resilience against a wide range of perturbations. Yet remarkably little is known about how the community functions as a system. We are exploring this by asking two broad questions: How do groups of organisms work together to influence immune function? What are the mechanisms that govern metabolism and ecology at the 100+ strain scale? Our goal is to learn rules that will enable us to design communities that solve specific therapeutic problems.
2) Strain-level mechanisms. Even though gut and skin colonists live in communities, individual strains can have an extraordinary impact on host biology. We focus on two broad (and partially overlapping) categories:
Immune modulation: Can we redirect colonist-specific T cells against an antigen of interest by expressing it on the surface of a bacterium? How do skin colonists induce high levels of Staphylococcus-specific antibodies in mice and humans?
Abundant microbiome-derived molecules: By constructing single-strain/single-gene knockouts in a complex defined community, we will ask: What are the effects of bacterially produced molecules on host metabolism and immunology? Can the molecular output of low-abundance organisms impact host physiology?
3) Cell and gene therapy. We have begun two new efforts in mammalian cell and gene therapies. First, we are developing methods that enable cell-type specific delivery of genome editing payloads in vivo. We are especially interested in delivery vehicles that are customizable and easy to manufacture. Second, we have begun a comprehensive genome mining effort with an emphasis on understudied or entirely novel enzyme systems with utility in mammalian genome editing. -
Adina S. Fischer, MD, PhD
BioDr. Fischer’s research focuses on characterizing risk and resilience factors in depression. She has been awarded an NIH Career Development Award (K23) and Klingenstein Foundation Fellowship in Adolescent Depression to build her program of clinical and translational research at Stanford. Dr. Fischer's program of clinical care focused on the delivery and teaching of evidence-based clinical interventions that enhance resilience, with a focus on addressing the unique stressors encountered in academia and academic medicine that may contribute to risk and resilience in mood and anxiety disorders.
Dr. Fischer’s translational program of research focuses on:
(1) Improving our understanding of protective biomarkers of resilience to depression
(2) Characterizing the effects of cannabis on neurobiological function and depressive symptoms
(3) Developing neurobiologically-guided interventions for depressive disorders, particularly those that co-occur with cannabis and other substance use
Dr. Fischer earned her BSc at the Massachusetts Institute of Technology in Brain and Cognitive Sciences, where she conducted research in the Early Childhood Cognition Laboratory. She then completed the MD/PhD Program at Dartmouth, where she obtained her PhD in in Neuroscience. Dr. Fischer’s doctoral research focused on characterizing the acute effects of cannabis in patients with schizophrenia and co-occurring cannabis use disorder. She then completed the Stanford Psychiatry Residency Training Program as a member of the Research Track, and an NIH funded T-32 postdoctoral research fellowship within the Department of Psychiatry and Behavioral Sciences. -
Paul Graham Fisher, MD
Beirne Family Professor of Pediatric Neuro-Oncology, Professor of Pediatrics and, by courtesy, of Neurosurgery and of Epidemiology and Population Health
Current Research and Scholarly InterestsClinical neuro-oncology: My research explores the epidemiology, natural history, and disease patterns of brain tumors and other cancers in childhood, as well as prospective clinical trials for treating these neoplasms. Research interests also include neurologic effects of cancer and its therapies.
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Philip Andrew Fisher
Diana Chen Professor of Early Childhood Learning and Professor, by courtesy, of Pediatrics
BioDr. Philip Fisher is the Diana Chen Professor of Early Childhood Learning in the Graduate School of Education and the Director of the Stanford Center on Early Childhood. His research, focuses on developing and evaluating scalable early childhood interventions in communities, and on translating scientific knowledge regarding healthy development under conditions of adversity for use in social policy and programs. He is particularly interested in the effects of early stressful experiences on children's development, and in prevention and treatment programs for improving children's functioning in areas such as relationships with caregivers and peers, social-emotional development, and academic achievement. He is currently the lead investigator in the ongoing RAPID-EC project, a national survey on the well-being of households with young children during the COVID-19 pandemic. Dr. Fisher is the developer of a number of widely implemented evidence-based interventions for supporting healthy child development in the context of social and economic adversity, including Treatment Foster Care Oregon for Preschoolers (TFCO-P) and Kids in Transition to School (KITS). Most recently, he developed the Filming Interactions to Nurture Development (FIND) video coaching program for supporting parenting in the home environment and early childhood care and education professionals in childcare and preschool contexts. He has published over 250 scientific papers in peer reviewed journals. He is the recipient of the 2012 Society for Prevention Research Translational Science Award, and a 2019 Fellow of the American Psychological Society.
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Robert Fisher, MD, PhD
The Maslah Saul, MD, Professor and Professor, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsDr. Fisher is interested in clincal, laboratory and translational aspects of epilepsy research. Prior work has included: electrical deep brain stimulation for epilepsy, studied in laboratory models and clinical trials; drug delivery to a seizure focus; mechanisms of absence epilepsy studied with in vitro slices of brain thalamus; hyperthermic seizures; diagnosis and treatment of non-epileptic seizures, the post-ictal state; driving and epilepsy; new antiepileptic drugs; surgery for epilepsy.
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Matthew Fitzgerald, PhD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsMy research encompasses several translational projects. One focus is to modify the routine audiologic test battery such that it places equal weight on hearing acuity and hearing function. This work includes measures of speech in noise, or electrophysiologic responses such as the FFR. I also explore tools to better assess and maximize performance in users of hearing aids and cochlear implants. Finally, I am also investigating the benefits of telemedicine, and new treatments for tinnitus.
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Pamela Flood
Adjunct Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
BioDr. Flood is a Professor at Stanford University who is fellowship trained in Pain Medicine and Obstetric Anesthesiology. She specializes in the treatment of chronic pelvic pain and multiple aspects of women's health including the prevention of chronic pain after childbirth. Research interests include the role of multimodal treatment in chronic pain conditions and prevention of persistent opioid use. Her research has spanned from detailed pharmacodynamic analysis, clinical trials to population health.
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Eric Foote
Clinical Assistant Professor, Pediatrics - Neonatology
BioEric Foote is a pediatric hospitalist with experience conducting clinical and public health research around the world. His research focuses on identifying and intervening on health disparities in low income countries and in low resource settings. Currently, he is developing and evaluating a community health worker-led household phototherapy intervention to extend access to neonatal jaundice care for newborns in rural Bangladesh. He is also working to improve SARS-CoV-2 testing and genomic surveillance across California and worldwide.
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Daiana Fornes
Life Science Research Professional 3, Obstetrics Anesthesiology
BioDaiana Fornes is a postdoctoral scholar at Stanford University, supported by a Maternal & Child Health Research Institute (MCHRI) Postdoctoral Fellowship. Her research centers on reproductive biology and pregnancy disorders, with a particular focus on uterine contractility, preterm labor, and uterine atony. She investigates calcium signaling pathways, including the role of TRPV4 ion channels, to identify novel therapeutic strategies aimed at improving maternal health outcomes.
Daiana earned her PhD from the University of Buenos Aires, where she studied metabolic alterations during pregnancy and their effects on fetal development. Her training has provided her with a strong foundation in translational research, with extensive experience in experimental design, molecular biology, and the analysis of signaling pathways.
