School of Medicine
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Seth Lawrence Sherman, MD
Associate Professor of Orthopaedic Surgery
Current Research and Scholarly InterestsMy research focuses on ways to augment tissue healing, improve human performance, and prevent musculoskeletal injuries. Approaching these challenges through parallel basic science and clinical pathways, our team works from the “bedside to the bench and back to the bedside”, identifying areas of clinical need to deliver evidence-based solutions for patients.
We collaborates with orthopaedic surgeons, non-surgical physicians, and researchers within bioengineering, human performance, and musculoskeletal imaging across the Stanford campus. The team is developing novel methods to accurately record human movement (including wearable technology, phone-based systems), rapid MRI imaging protocols, and exploring the use of biomarkers to track injury and recovery. This research builds on my earlier work, which utilized portable, inexpensive software for Microsoft Kinect to detect knee injury risk in youth athletes performing a drop vertical jump test. The team’s multifaceted goal is: 1) develop innovative methods to screen for injury risk (i.e. youth athlete non-contact ACL), 2) create targeted intervention programs to reduce risk, 3) enhance athletic performance; and 4) improve accuracy of return to play testing following injury/surgery (i.e. clinical evaluation, biomarkers, functional tests, imaging analysis for healing).
In the laboratory,our team investigates cellular and molecular deficiencies in tissue types including tendon, ligament, articular cartilage, and meniscus. By understanding aberrant pathways leading to tissue injury, they can identify innovative therapeutic targets for intervention. In collaboration with the Genetic Engineering and Synthetic Biology laboratories, Dr. Sherman’s research has explored the role of orthobiologic agents such as platelet rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) for tissue healing in patella tendinopathy (the breakdown of collagen in a tendon). Our lab is also investigating the use of CBD for musculoskeletal applications as an alternative to commonly used local anesthetics and cortisone derivatives. In my earlier work, we researched the cellular toxicity of such applications.
In addition to basic science research, I have helped to build a Sports Medicine clinical research team that includes several full-time clinical research coordinators, residents, fellows, and students. The team collects prospective outcomes on their patients using a novel data collection platform called Patient IQ. The group is part of the JUPITER study which is the largest, multicenter study ever assembled in patellofemoral instability. They are additionally planning to enroll in FDA-approved clinical studies investigating pioneering strategies for knee cartilage restoration, joint preservation, and orthobiologic injections for osteoarthritis. Recent clinical publications explore outcomes in meniscus preservation and transplantation, medial patellofemoral ligament reconstruction, osteochondral allograft and matrix-induced autologous chondrocyte implantation (MACI), and surgical augmentation using PRP/BMAC. The clinical research team actively reports results of non-surgical and surgical interventions to continue to introduce new knowledge to the field, with the goal of improved patient outcome. -
Vipul Sheth, MD, PhD
Assistant Professor of Radiology (Body MRI)
Current Research and Scholarly InterestsMy interests are in the development and translation of imaging technologies geared toward disease detection and characterization to better guide prognosis, treatment, and improve outcomes. I’m interested in supporting the development of MRI guided focal therapy methods which can personalize treatment and reduce the risk of morbidity from more invasive therapies.
Clinical Interests
- MRI for diagnosis of pelvic floor disorders
- MRI and PET/MRI to pelvic malignancies and lymph node staging.
- Whole Body MRI
- MRI guided procedures including biopsies, cryoablation, and high intensity focused ultrasound.
Translational Research Interests
- Development and translation of magnetic resonance imaging technologies to improve both diagnostics and therapeutics
- Molecular imaging and characterization of the tumor microenvironment
- Ultrashort echo time MRI applications in the body
- Developing synergistic MRI methods to complement PET in potential applications for PET/MRI -
Run Zhang Shi
Clinical Associate Professor, Pathology
Current Research and Scholarly InterestsClinical chemistry and therapeutic drug monitoring;
adult and pediatric clinical endocrine testing;
screening, detection and follow up of multiple myeloma;
tumor markers;
clinical utility of tandem mass spectrometry and high resolution mass spectrometry. -
Vivian Shih, MD
Clinical Associate Professor, Orthopaedic Surgery
BioDr. Vivian Shih received her Bachelor of Science with honors and Doctor of Medicine degree from the University of Miami. In 2002, she completed her postgraduate medical training in Physical Medicine and Rehabilitation at the Feinberg School of Medicine at Northwestern University and the Rehabilitation Institute of Chicago (Shirley Ryan Ability Lab). She is board certified in Physical Medicine and Rehabilitation (PM&R or Physiatry) and specializes in non-surgical management of musculoskeletal disorders, arthritis, gait and balance disorders. She also performs electrodiagnostic testing (EMG/NCS), ultrasound guided joint/soft tissue injections, and platelet rich plasma (PRP) injections. Dr. Shih previously practiced in the New Haven area from 2005 to 2018. She was an Attending Physician at Yale-New Haven Hospital and on faculty at the Yale School of Medicine. Prior to that, she had been practicing at Northwestern University Medical Center and the Rehabilitation Institute of Chicago. She has published in the Arthritis and Rheumatism journal, Academy of Physical Medicine & Rehabilitation (AAPM&R) online review, Archives of Physical Medicine and Rehabilitation journal, and Koopman's Arthritis and Allied Health textbook. She is a member of the AAPM&R, Association of Academic Physiatrists (AAP), and the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM).
