Clinical Focus

  • Pediatric Rheumatology

Academic Appointments

Professional Education

  • Fellowship: Medical College of Wisconsin Dept of Pediatrics (2025) WI
  • Board Certification: American Board of Pediatrics, Pediatrics (2018)
  • Residency: University of Chicago Dept of Pediatrics (2018) IL
  • Medical Education: Michigan State University College of Human Medicine (2015) MI

Contact

  • Clinical (Primary)  Pediatric Rheumatology 730 Welch Rd 2nd Fl Palo Alto, CA 94304 (650) 736-4344 (fax)

Additional Clinical Info

All Publications

  • Effective performance of the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for Antineutrophil-Cytoplasmic-Antibody-Associated Vasculitis in Pediatric Patients: an ARChiVe Study. Arthritis & rheumatology (Hoboken, N.J.) Cabral, D. A., Bosman, E. S., McPhate, N., Mann, S. K., Toor, K. K., Morishita, K. A., Luqmani, R., Beresford, M. W., Bistolarides, J., Campillo, S., Charuvanij, S., Cook, K., Dancey, P., de Guzman, M., Deepak, S., Eberhard, B., Elder, M., Gagne, S., Harrison, K., Huber, A., Khan, A., Kim, S., Klein-Gitelman, M. S., Lee, T. C., Li, S. C., Martin, N., McErlane, F., Moorthy, L. N., Orjuela, A. H., Park, J., Riley, P., Rosenberg, A. M., Shenoi, S., Sivaraman, V., Sutnga, S., Tanner, T., Tarvin, S. E., Twilt, M., Wagner-Weiner, L., Yeung, R. S., Brown, K. L., ARChiVe Investigators Network within the PedVas Initiative 2026

    Abstract

    OBJECTIVE: To assess the 2022-ACR/EULAR classification criteria for ANCA-associated vasculitis (AAV) in children with chronic small-to-medium vessel vasculitis.METHODS: A cohort of 574 patients, identified by physician's-(MD)-diagnosis in A-Registry-of-Childhood-Vasculitis, were classified by computation of registry data, as having granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) or eosinophilic GPA (EGPA) after applying (1) ACR/EULAR AAV criteria and (2) pediatric-adapted European Medicines Agency (Ped-EMA) classification algorithm (incorporating Ankara GPA criteria). Venn diagrams compared the resulting GPA/MPA cohorts with MD-diagnosis. Sensitivity and specificity of criteria for GPA were evaluated against MD-diagnosis. Fisher's exact test evaluated differences in the frequencies of individual clinical features in GPA versus MPA.RESULTS: Comparing ACR/EULAR criteria against Ped-EMA-algorithm for classifying AAV, respectively, more patients were classified as GPA or MPA (n=396 versus 360), fewer had GPA (n=261 versus 288), more had MPA (135 versus 72), and fewer GPA cases co-classified as MPA (12% versus 28%); there were more differences between GPA and MPA in PVAS-defined clinical features (n=14 versus 10).When classifying GPA by ACR/EULAR or Ankara criteria, respectively sensitivity (74.5% versus 72.1%) was comparable, and specificity for ACR/EULAR criteria (93.9% versus 79.9%) was improved.CONCLUSION: The 2022 ACR/EULAR classification criteria for AAV performs at least as well as previous pediatric criteria and provide categorical MPA criteria where none existed previously; the criteria for GPA and MPA now specifically differentiate each other, with more differences between them in the frequencies of clinical features. Our findings support the preferential use of ACR/EULAR over Ankara criteria for GPA in pediatrics.

    View details for DOI 10.1002/art.70172

    View details for PubMedID 41958151