Pediatrics
Showing 51-99 of 99 Results
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Seung K. Kim M.D., Ph.D.
KM Mulberry Professor, Professor of Developmental Biology, of Medicine (Endocrinology) and, by courtesy, of Pediatrics (Endocrinology)
Current Research and Scholarly InterestsPancreatic islets are essential for human health. We study the development and function of islet cells using modern methods in several model systems, including mice, pigs, human pancreas, primates, embryonic stem cells, and fruit flies. We have discovered critical factors required for islet development and mature islet cell function. These approaches have informed efforts to generate replacement islets, and provide immune protection of transplanted islets for diabetes.
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Yong Yean Kim
Assistant Professor of Pediatrics ( Hematology & Oncology)
BioOur lab is interested in translational science to bring new therapies to clinical trials. In particular, we are interested in pediatric sarcomas which have not had advancement in clinical treatment for decades. Current projects in the lab focus on understanding of the biology of fusion transcription factor PAX3::FOXO1 which is the driver mutation in fusion positive rhabdomyosarcoma. PAX3::FOXO1 is a powerful oncogenic transcription factor which rewires the transcriptional organization to lock the cancer cell in the proliferative state. Since transcription factors including PAX3::FOXO1 are difficult to target using small molecules, we aim to understand how PAX3::FOXO1 is regulated and targeting the regulators of PAX3::FOXO1. By understanding and targeting the regulation of PAX3::FOXO1, we hope to bring new therapies for fusion positive rhabdomyosarcoma. Additionally, these regulatory mechanisms may also be active in other transcription driven cancers such as the EWSR1::FLI1 driven Ewings Sarcoma.
Our lab is also interested in exploring the epigenetic landscape of pediatric solid tumors and trying to understand how dysregulation in the epigenome drives oncogenesis. We utilize various CRISPR mediated genetic techniques to interrogate the regulators of epigenome focusing on the histone lysine demethylases (KDMs). KDMs are an understudied group of epigenetic regulators which can be targeted for therapeutic effect. We explore the role of KDMs in pediatric solid tumors and hope to identify potential targets for drug development. -
Alaina Kipps
Clinical Professor, Pediatrics - Cardiology
BioDr. Kipps grew up in Santa Cruz, California and completed her medical degree at Harvard Medical School in 2003. After general pediatrics residency at Stanford, she completed pediatric cardiology fellowship at Boston Children’s Hospital from 2006 to 2009. After three years on faculty with University of California, San Francisco she was recruited back to Stanford in 2012 to become the medical director for acute care cardiology (2013-2021). Since 2021 she has focused on QI for the ACCU and heart center, and has served as the ACCU local improvement team medical director since 2013. In 2014 she co-founded the Pediatric Acute Care Cardiology Collaborative (PAC³) with Nicolas Madsen and co-directed this since inception to spring 2026. PAC³ has 50 participating centers, a registry since 2019 with >150,000 encounters, and is the academic society for the ACCU subspecialty. Her academic focus is in clinical effectiveness and quality improvement science, and she completed her Masters of Science in Epidemiology at Harvard School of Public Health in 2016. Her other significant interest is in teaching, mentorship, and coaching. She is the co-director of the Pediatric residency program scholarly concentration in Quality Improvement, co-leads the Pediatric department peer scholar community (in QI), and has served as a residency coach since 2020.
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Varvara A. Kirchner
Associate Professor of Surgery (Abdominal Transplantation) and, by courtesy, of Pediatrics
BioDr. Kirchner completed her medical school, surgical residency and multi-organ transplant fellowship in adult and pediatric liver, pancreas, kidney transplantation and total pancreatectomy with islet auto-transplantation at the University of Minnesota. She underwent further training in living donor liver transplantation and hepatobiliary surgery at the Asan Medical Center, Seoul, South Korea. Her clinical practice involves living and deceased donor liver and kidney transplantation in adult and pediatric patients as well as total pancreatectomy with islet auto-transplantation for patients with chronic and acute recurrent pancreatitis. She currently serves as Surgical Director of the Islet Cell Auto-Transplant at Stanford Children’s and Associate Director of the Living Donor Liver Transplant Program at the Division of Abdominal Transplantation. Dr. Kirchner’s research focuses on the biology of aging, cellular and solid organ transplantation. Her specific interests are in auto-islet transplantation, iPSC-derived hepatocyte therapies and liver regeneration. Dr. Kirchner's research on the impact of donor age on generation of iPSC-derived hepatocyte-like cells is supported by the NIA K08 Faculty Development Award. She is an active member of the American Society of Transplant Surgeons and the International Liver Transplantation Society.
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Jonathan D Klein
Marron and Mary Elizabeth Kendrick Professor of Pediatrics
Current Research and Scholarly InterestsMy studies address:
1. Confidentiality and Access to Care studies of confidential time during well-visits and policy analyses addressing quality of care and health systems capacity for adolescents and young adults in the US and globally; and,
2, Tobacco, nicotine, and second-hand smoke studies of primary care counseling to reduce nicotine addiction in adolescents and programs to engage medical specialty groups in secondhand smoke clinical and policy interventions. -
Nathan Kline
Adolescent Screenomics Study Coordinator, Peds/Disease Prevention
Current Role at StanfordAs the Adolescent Screenomics Study Coordinator, I have collaborated with Dr. Tom Robinson and the rest of the Stanford Solutions Lab team to create the groundwork for the Adolescent Screenomics study. Some of this groundwork includes: developing and maintaining a RedCap project with over 20 instruments and over 800 notifications with branching logic. I also have been collaborating with programmers and RedCap administrators to manage compensation related to smartphone use, create a zoom scheduler to onboard adolescent participants, and automate the distribution of gift cards. Moreover, I have been developing and maintaining our study website. Finally, I have been developing advertisements on Facebook, Instagram, etc. to advertise for our study. Once our study is approved by the IRB officially, I will begin recruiting and onboarding adolescent participants, obtaining informed consent (from their parents/guardians) and assent, and monitoring completion of the study.
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Hanna Maria Knihtila
Affiliate, Pediatrics - Immunology
BioHanna Knihtilä is an Allergy and Immunology Fellow at Stanford. She gained her MD in 2017 and PhD in 2018 from the University of Helsinki, Finland. She then completed her 2-year postdoctoral research fellowship at the Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, before joining Stanford for her residency and fellowship training.
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Juliet Klasing Knowles
Assistant Professor of Neurology and Neurological Sciences (Pediatric Neurology) and of Pediatrics
Current Research and Scholarly InterestsThe Knowles lab studies how white matter structure changes in different forms of epilepsy, and how aberrant white matter structure, in turn, shapes neuronal network function. In mouse models, we use a variety of innovative tools including neurophysiology, quantitative EEG, behavior, histological measures of white matter structure and MR imaging. We also conduct clinical research to study white matter abnormalities in children with epilepsy.
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Katherine C. Konvinse, MD, PhD
Clinical Assistant Professor, Pediatrics - Immunology
BioKatherine Konvinse, MD, PhD is an Allergy and Immunology Fellow at Stanford Medicine. She completed her residency in the Stanford Pediatric Residency Research Track Program.
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Euna Koo, MD
Clinical Associate Professor, Ophthalmology
Clinical Assistant Professor (By courtesy), PediatricsBioDr. Koo is an ophthalmologist specializing in pediatric ophthalmology and adult strabismus. She received her ophthalmology training at UC San Francisco and then her fellowship training in pediatric ophthalmology and adult strabismus at Boston Children's Hospital affiliated with Harvard Medical School. She has been board certified by the American Board of Ophthalmology since 2016. Her practice reflects her clinical interests in pediatric ophthalmology and in adult strabismus.
She utilizes Botox in management of adult and pediatric strabismus. She also uses hidden adjustable sutures in children and adults to optimize alignment of eyes with surgery. Muscles can be adjusted up to 7-10 days after surgery.
She is active in training both residents and fellows in ophthalmology. -
Alan M. Krensky, M.D.
Shelagh Galligan Professor in the School of Medicine, Emeritus
Current Research and Scholarly InterestsMechanisms and therapies for infection, cancer, autoimmunity and transplantation.
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Calvin Kuo
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
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Christin S Kuo
Assistant Professor of Pediatrics (Pulmonary Medicine)
BioDr. Kuo is a physician-scientist with expertise in single-cell genomics and pulmonary medicine. She has made pioneering contributions to pulmonary neuroendocrine cell (PNEC) biology by developing innovative strategies that established the first comprehensive framework for understanding the molecular and cellular diversity of normal PNECs and their roles in health and disease. Her discoveries have laid the foundation for this emerging field and her contributions are recognized internationally.
PNECs are exceedingly rare lung epithelial cells with specialized airway sensory, secretory, and stem cell functions. These neurosensory cells are thought to monitor airway oxygen, chemicals, mechanical deformation, infection, and injury, and serve as sentinels that signal this sensory information locally in the lung, to the brain through synapses with pulmonary sensory neurons and potentially globally throughout the body via secretion of myriad local signals and hormones. PNECs are also known to play critical roles in the control of breathing, cough, and respiratory physiology. Among their diverse physiologic functions, their response to injury has been most intensively studied in murine models and they are a cell of origin for high grade lung neuroendocrine tumors.
Dr. Kuo performed the first comprehensive anatomical mapping and lineage tracing studies of PNECs in mice which generated a foundational understanding of PNEC development (Kuo and Krasnow, Cell 2015). She also led single cell transcriptomic profiling studies that revealed a surprising diversity in PNEC sensors and signals (Kuo et al, eLife 2022). PNECs express over 25 different sensory receptor genes ("sensors") and over 40 different neuropeptide and peptide hormone genes ("signals"). Her scRNA-seq analysis of PNECs revealed a remarkable number and diversity of PNEC neuropeptide signals and their predicted cellular targets both within the lung and to innervating sensory neurons (Kuo et al., 2022, eLife).
In contrast to the advanced understanding of PNEC development, stem cell, and signaling function in mouse, little is known about human PNECs. To compare the findings of PNEC development, diversity, and function in mouse models to human diseases, her lab recently established a platform to systematically construct a human PNEC atlas. This foundational work created a molecular and anatomic framework for the entire human pulmonary neuroendocrine system and the diseases that are predicted to originate from distinct PNECs. Her lab has recently used this new PNEC atlas combined with single cell transcriptomic approaches to identify the molecular diversity of anatomically and functionally distinct human PNECs.
Dr. Kuo's studies with human models extends her lab’s current research aims to define the diverse neuroendocrine sensory and signaling interactions and the molecules that mediate them to their roles in lung cancer, neuroendocrine proliferative disorders such as diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH), neuroendocrine cell hyperplasia of infancy (NEHI) and major inflammatory and obstructive pulmonary diseases. Dr. Kuo’s lab engages a network of collaborators to develop and implement clinical protocols and strategically apply cutting-edge technologies to studying minor, but physiologically diverse airway sentinels.
Please visit the research website for additional information and current research areas (https://kuo.stanford.edu).
