School of Medicine
Showing 1-50 of 233 Results
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Shin Yajima
Postdoctoral Scholar, Cardiothoracic Surgery
BioI am a board-certified attending cardiothoracic surgeon in Japan. Throughout my clinical experience and research, I found that insufficient myocardial blood flow had little impact on myocardial functional recovery since percutaneous coronary intervention or coronary artery bypass grafting (CABG) could approach and supply blood flow to the superficial large coronary arteries, but not to intramyocardial microvascular arteries, particularly where microvasculature was either scarce or absent. In addition, myocardial ischemia-reperfusion (I/R) adversely affected cardiac functional recovery in ischemic hearts, including transplanted hearts. Therefore, I have a keen interest in addressing myocardial microvascular dysfunction and myocardial I/R injury in research.
During my Ph.D. in cardiovascular surgery, I focused on a prostacyclin analog that has thromboxane A2 synthase inhibitory activity and can promote angiogenesis and restore myocardial blood flow through proangiogenic and vasodilatory effects. I applied a microform of this compound in the porcine ischemia cardiomyopathy model with a direct epicardial placement, elucidating promoted myocardial angiogenesis, leading to myocardial function recovery. Then, I developed nanoparticles (NPs) that incorporated this compound which I subsequently applied to a rat ischemia myocardial reperfusion model with intravenous injection to elucidate attenuated myocardial I/R injury with selective accumulation in the ischemic myocardium, better-preserved capillary networks, a better-preserved myocardial blood flow, and a smaller infarct size. Furthermore, I have worked on tissue engineering for myocardial regeneration using induced pluripotent stem cells (iPSCs) and adipose-derived mesenchymal stem cells. With human iPSCs-derived cardiomyocyte sheets of direct implantation on the ischemic myocardial tissue, we elucidated myocardial regeneration through thickened myocardial tissue, proangiogenic effects, improved cardiac performance, and attenuated left ventricular remodeling in both small and large animals. These works have already been published (below are representative), and I gained several academic awards and research grants (ongoing research support; Japan Heart Foundation/Bayer Research Grant Abroad, 01/01/2022 - 12/31/2022).
My career goal is to become a leader in academic cardiovascular surgery. During my postdoctoral fellowship, I plan to develop novel therapeutic methods to obtain better outcomes for ischemic heart disease in which there is room for improvement through engineering analysis and the creation of innovative solutions. I am extremely excited to start on the proposed project, as it perfectly intertwines my bioengineering background and clinical interests. As such, the School of Medicine Dean's Postdoctoral Fellowship will be invaluable to my development as a young investigator. Dr. Woo is an exceptional mentor with remarkable renown for training academic surgeons and Stanford University provides incredible resources for research. I feel extremely fortunate to have such an ideal environment to carry out this project and continue advancing the field of cardiothoracic surgery through bioengineering. -
Fan Yang
Associate Professor of Orthopaedic Surgery and of Bioengineering
Current Research and Scholarly InterestsOur research seeks to understand how microenvironmental cues regulate stem cell fate, and to develop novel biomaterials and stem cell-based therapeutics for tissue engineering and regenerative medicine. Our work spans from fundamental science, technology development, to translational research.We are particularly interested in developing better therapies for treating musculoskeletal diseases, cardiovascular diseases and cancer.
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Fan Yang
Postdoctoral Scholar, Pathology
BioFan Yang has a broad background in Computational Biology, Genomics, Oncology, Immunology, and their intersections. She did her Ph.D. at the University of Toronto and participated in several inspiring and cutting-edge projects focusing on assessing the functionality and immunogenicity of human genomic variants both experimentally and computationally. She joined the Boyd lab at Stanford for her postdoctoral work to study the B cell and T cell repertoires in human infectious diseases and vaccine responses.
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Phillip C. Yang, MD
Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsDr. Yang is a physician-scientist whose research interest focuses on clinical translation of the fundamental molecular and cellular processes of myocardial restoration. His research employs novel in vivo multi-modality molecular and cellular imaging technology to translate the basic innovation in cardiovascular pluripotent stem cell biologics. Dr. Yang is currently a PI on the NIH/NHLBI funded CCTRN UM1 grant, which is designed to conduct multi-center clinical trial on novel biological therapy.
