Brian Robert Smith

All Publications

• Pulchritudo ex machina: Beauty from the machine. Palliative & supportive care Smith, B. R. 2022: 1-2

  View details for DOI 10.1017/S1478951522001572

  View details for PubMedID 36367107

• Captive. Tuberculosis and respiratory diseases Smith, B. R. 2022

  View details for DOI 10.4046/trd.2022.0130

  View details for PubMedID 36281545

• Heavy hangs the coat. AEM education and training Smith, B. R. 2022; 6 (5): e10807

  View details for DOI 10.1002/aet2.10807

  View details for PubMedID 36258906

• From books to bedsides AEM EDUCATION AND TRAINING Smith, B. R. 2022; 6 (5): e10811

  View details for DOI 10.1002/aet2.10811

  View details for Web of Science ID 000859688700001

  View details for PubMedID 36189453

  View details for PubMedCentralID PMC9513529

• Deluge. Journal of the American Geriatrics Society Smith, B. R. 2022

  View details for DOI 10.1111/jgs.18073

  View details for PubMedID 36178965

• Bedbound PALLIATIVE & SUPPORTIVE CARE Smith, B. R. 2022

  View details for DOI 10.1017/S1478951522001213

  View details for Web of Science ID 000853244400001

• Safety Net. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Smith, B. R. 2022

  View details for DOI 10.1111/acem.14593

  View details for PubMedID 36073240

• Code. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Smith, B. R. 2022

  View details for DOI 10.1111/acem.14578

  View details for PubMedID 35989558

• On a scale from one to ten. Palliative & supportive care Smith, B. R. 2022: 1

  View details for DOI 10.1017/S1478951522000803

  View details for PubMedID 35735029

• Induction. Anesthesiology Smith, B. R. 2022

  View details for DOI 10.1097/ALN.0000000000004286

  View details for PubMedID 35727085

• Letter from a medical oncology scribe Palliative & Supportive Care Smith, B. R. 2022

  View details for DOI 10.1017/S1478951522000281

• On Diction. JAMA oncology Smith, B. R. 2021

  View details for DOI 10.1001/jamaoncol.2021.2730

  View details for PubMedID 34382997

• High-Parametric Evaluation of Human Invariant Natural Killer T Cells to Delineate Heterogeneity in Allo- and Autoimmunity. Blood Erkers, T., Xie, B., Kenyon, L. J., Smith, B., Rieck, M., Jensen, K. P., Ji, X., Basina, M., Strober, S., Negrin, R. S., Maecker, H. T., Meyer, E. 2020

  Abstract

  Human invariant natural killer T cells (iNKTs) are a rare innate-like lymphocyte population that recognize glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogenous and capable of enacting diverse functions, and the composition of iNKT subsets can alter disease outcomes. In contrast, far less is known about how heterogeneity in human iNKTs relates to disease. To address this, we use a high-dimensional, data-driven approach to devise a framework to parse human iNKT heterogeneity. Our data revealed novel and previously described iNKT phenotypes with distinct functions. In particular, we found two phenotypes of interest: 1) a population with Th1 function that was increased with iNKT activation characterized by HLA-II+CD161- expression, and 2) a population with enhanced cytotoxic function characterized by CD4-CD94+ expression. These populations, respectively, correlate with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and with new onset type 1 diabetes. Our study identifies human iNKT phenotypes associated with human disease that could aid in the development of biomarkers or therapeutics targeting iNKTs.

  View details for DOI 10.1182/blood.2019001903

  View details for PubMedID 31935280