Brian Robert Smith

All Publications

• Lisocabtagene Maraleucel for Richter's Transformation-A Case Series. EJHaem Smith, C. J., Goyal, A., Smith, B. R., Lee, D., Jensen, A., Alexander, J., Smith, M., Frank, M., Dahiya, S., Miklos, D., Bharadwaj, S. 2025; 6 (2): e270011

  Abstract

  Richter's transformation (RT) from chronic lymphocytic leukemia (CLL) to lymphoma carries poor prognosis. This case series examines the efficacy of lisocabtagene maraleucel (liso-cel) in six RT patients, highlighting the impact of concurrent ibrutinib therapy.Six patients were with RT who received liso-cel from were included in this single institution case series. Clinical data related to efficacy, safety, CAR-T expansion kinetics, and measurable residual disease were collected.The best overall response was 83.3%. The four patients who received ibrutinib concurrent with liso-cel therapy continue to show MRD-negative complete response till date. None experienced severe (grade 3+) cytokine release syndrome while 1 had severe (grade 3+) immune-effector cell-associated neurotoxicity syndrome (ICANS). All patients were noted to have in vivo CAR expansion.This series of real cases suggests liso-cel with concurrent ibrutinib may be a promising treatment for RT, warranting further exploration.

  View details for DOI 10.1002/jha2.70011

  View details for PubMedID 40066130

  View details for PubMedCentralID PMC11891774

• Golden. Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry Smith, B. R. 2023

  View details for DOI 10.1007/s40596-023-01915-1

  View details for PubMedID 38017335

• Lighthouse. Anesthesia and analgesia Smith, B. R. 2023; 137 (5): 1112-1113

  View details for DOI 10.1213/ANE.0000000000006311

  View details for PubMedID 37862402

• Real Magic. Anesthesia and analgesia Smith, B. R. 2023; 137 (5): 1110-1111

  View details for DOI 10.1213/ANE.0000000000006264

  View details for PubMedID 37862401

• Lighthouse. Anesthesia and analgesia Smith, B. R. 2023; 137 (5): 1112-1113

  View details for DOI 10.1213/ANE.0000000000006311

  View details for PubMedID 40009004

• Treading Through Twilight. Anesthesiology Smith, B. R. 2023

  View details for DOI 10.1097/ALN.0000000000004661

  View details for PubMedID 37610370

• Annals Graphic Medicine - Preparing for a Genomic Future. Annals of internal medicine Smith, C. J., Smith, B. R. 2023

  View details for DOI 10.7326/G22-0055

  View details for PubMedID 37549392

• "That Was Terrible": Public Humiliation in Preclinical Education. Academic medicine : journal of the Association of American Medical Colleges Smith, B. R. 2023

  View details for DOI 10.1097/ACM.0000000000005429

  View details for PubMedID 37556807

• Sunsets. JAMA oncology Smith, B. R. 2023

  View details for DOI 10.1001/jamaoncol.2023.2179

  View details for PubMedID 37498622

• Annals Graphic Medicine - Dependence. Annals of internal medicine Smith, B. 2023: eG220051

  View details for DOI 10.7326/G22-0051

  View details for PubMedID 37364266

• Matter. Palliative & supportive care Smith, B. R. 2023: 1-2

  View details for DOI 10.1017/S1478951523000792

  View details for PubMedID 37357956

• Lost and Found in the ER. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Smith, B. R. 2023

  View details for DOI 10.1111/acem.14759

  View details for PubMedID 37285060

• Bearer of bad news. Canadian medical education journal Smith, B. R. 2023; 14 (3): 360

  View details for DOI 10.36834/cmej.76145

  View details for PubMedID 37465734

• Celebrating synergy. Canadian medical education journal Smith, B. R. 2023; 14 (3): 361

  View details for DOI 10.36834/cmej.77279

  View details for PubMedID 37465743

  View details for PubMedCentralID PMC10351624

• My first day in the ER: Should I be worried about. Families, systems & health : the journal of collaborative family healthcare Smith, B. R. 2023; 41 (2): 282

  Abstract

  In this poem, a medical resident describes his first day in the emergency room. He describes the patient bleeding and his plummeting pulse. The resident wonders if he worries too much or whether, when it truly matters, he will be enough. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

  View details for DOI 10.1037/fsh0000746

  View details for PubMedID 37338452

• Five visits with Diane. Families, systems & health : the journal of collaborative family healthcare Smith, B. R. 2023; 41 (2): 284-285

  Abstract

  This brief article is based on a patient's experience the author witnessed as a medical oncology scribe. The article describes five visits with a cancer patient named Diane as she started chemotherapy. Mere months since Diane's first visit, she died. The doctor read a slip of paper on her desk and told the author with tears in her eyes. The author turned over the visits she had with Diane, trying to find solace in the comfort she had in the end. It had all gone so fast, though. Four visits and she was gone. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

  View details for DOI 10.1037/fsh0000775

  View details for PubMedID 37338454

• Bonfire Abecedarian. The Journal of medical humanities Smith, B. R. 2023

  View details for DOI 10.1007/s10912-023-09802-4

  View details for PubMedID 37127836

• Greener Health Care Is a Necessity. AMA journal of ethics Smith, B. R. 2023; 25 (4): E294-298

  Abstract

  This series of 4 images visually considers ethical questions about the US health sector's emissions.

  View details for DOI 10.1001/amajethics.2023.294

  View details for PubMedID 37014725

• Bedbound. Palliative & supportive care Smith, B. R. 2023; 21 (2): 370

  View details for DOI 10.1017/S1478951522001213

  View details for PubMedID 39625273

• Falling apart. Canadian medical education journal Smith, B. R. 2023; 14 (2): 181

  View details for DOI 10.36834/cmej.76083

  View details for PubMedID 37304631

• Growth mindset. AEM education and training Smith, B. R. 2023; 7 (2): e10847

  View details for DOI 10.1002/aet2.10847

  View details for PubMedID 36936086

• Indelible. AEM education and training Smith, B. R. 2023; 7 (2): e10866

  View details for DOI 10.1002/aet2.10866

  View details for PubMedID 37064490

  View details for PubMedCentralID PMC10090485

• Keeping UpToDate. AEM education and training Smith, B. R. 2023; 7 (2): e10826

  View details for DOI 10.1002/aet2.10826

  View details for PubMedID 37008651

• Rheumatology's Animal Kingdom: A Digital Art Series. The Journal of rheumatology Smith, B. R. 2023

  Abstract

  During my first 2 years of medical school, I noticed how many syndromes and symptoms are named after animals. These visual metaphors are especially memorable because they evoke clear and vivid images and shapes.

  View details for DOI 10.3899/jrheum.230036

  View details for PubMedID 36858433

• Factors of transurethral incision effectiveness for ureteroceles in pediatric patients: A 28-year, single-institution retrospective review. Journal of pediatric urology Smith, B. R., Smith, C. J., Sharma, K., Sheth, K. R. 2023

  Abstract

  As a congenital anomaly, ureteroceles occur in 1 in 4000 children, and are usually diagnosed prenatally. However, there remains a lack of definite consensus on the optimal management of congenital ureteroceles.We evaluated factors associated with success of primary transurethral incision (TUI) in ureterocele pediatric patients.Demographic and clinical information for 120 pediatric patients who were diagnosed with congenital ureterocele between 1993 and 2021 at our institution were obtained through retrospective chart review. Data were analyzed using Fisher's exact tests, t-tests, and logistic regression with a significance threshold of p < 0.05. The primary outcome of ureterocele management was TUI effectiveness, defined by no need for further surgical intervention.Of the 120 patients (39 boys, 81 girls) with ureteroceles, 75 patients (22 boys, 53 girls) met our inclusion criteria of undergoing initial TUI ureterocele. Initial TUI was effective in 51/75 patients (68.0%). We analyzed possible correlative factors for TUI efficacy. Simplex system was a significant predictor of primary TUI efficacy (85% effective in simplex systems, 62% in duplex systems). Prior urinary tract infection, prenatal diagnosis, and electrocautery technique were all associated with an increased risk of needing additional surgeries after primary TUI.The most significant predictors of effective primary TUI were simplex system and the absence of preoperative vesicoureteral reflux. Prenatal diagnosis, preoperative febrile urinary tract infection, higher preoperative hydronephrosis grade, and the use of electrocautery were all associated with decreased primary TUI efficacy. Study limitations include that it was a retrospective chart review, and cohort size was limited by incomplete urology follow-up and operative records.Initial TUI was an effective procedure for the majority of our pediatric ureterocele patients, a higher success rate compared to other cohorts. Patients with a simplex system were more likely to have an effective first TUI than patients with duplex systems, as were patients without preoperative reflux. Although not statistically significant, our data suggest prior UTI, prenatal diagnosis, higher preoperative hydronephrosis grade, and the use of electrocautery may be associated with having additional surgeries.

  View details for DOI 10.1016/j.jpurol.2023.02.020

  View details for PubMedID 37002026

• Limbo. American journal of kidney diseases : the official journal of the National Kidney Foundation Smith, B. R. 2023

  View details for DOI 10.1053/j.ajkd.2022.09.009

  View details for PubMedID 36697357

• Side effects acrostic. Palliative & supportive care Smith, B. R. 2023: 1

  View details for DOI 10.1017/S1478951522001870

  View details for PubMedID 36635074

• Moments That Matter. Academic medicine : journal of the Association of American Medical Colleges Smith, B. R. 2023

  View details for DOI 10.1097/ACM.0000000000005118

  View details for PubMedID 36608353

• Sunrise, Sunset FAMILY MEDICINE Smith, B. R. 2023; 55 (1): 59-60

  View details for DOI 10.22454/FamMed.55.202982

  View details for Web of Science ID 001023245500012

• In Line. American journal of kidney diseases : the official journal of the National Kidney Foundation Smith, B. R. 2022

  View details for DOI 10.1053/j.ajkd.2022.10.005

  View details for PubMedID 36577603

• Rusty and Wooden. The Journal of rheumatology Smith, B. R. 2022; 49 (12): 1398-1399

  View details for DOI 10.3899/jrheum.220971

  View details for PubMedID 36455933

• Pulchritudo ex machina: Beauty from the machine. Palliative & supportive care Smith, B. R. 2022: 1-2

  View details for DOI 10.1017/S1478951522001572

  View details for PubMedID 36367107

• Captive. Tuberculosis and respiratory diseases Smith, B. R. 2022

  View details for DOI 10.4046/trd.2022.0130

  View details for PubMedID 36281545

• Worth Bearing in Mind. Academic medicine : journal of the Association of American Medical Colleges Smith, B. R. 2022

  View details for DOI 10.1097/ACM.0000000000005056

  View details for PubMedID 36538682

• Heavy hangs the coat. AEM education and training Smith, B. R. 2022; 6 (5): e10807

  View details for DOI 10.1002/aet2.10807

  View details for PubMedID 36258906

• From books to bedsides AEM EDUCATION AND TRAINING Smith, B. R. 2022; 6 (5): e10811

  View details for DOI 10.1002/aet2.10811

  View details for Web of Science ID 000859688700001

  View details for PubMedID 36189453

  View details for PubMedCentralID PMC9513529

• Deluge. Journal of the American Geriatrics Society Smith, B. R. 2022

  View details for DOI 10.1111/jgs.18073

  View details for PubMedID 36178965

• Bedbound PALLIATIVE & SUPPORTIVE CARE Smith, B. R. 2022

  View details for DOI 10.1017/S1478951522001213

  View details for Web of Science ID 000853244400001

• Safety Net. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Smith, B. R. 2022

  View details for DOI 10.1111/acem.14593

  View details for PubMedID 36073240

• Code. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Smith, B. R. 2022

  View details for DOI 10.1111/acem.14578

  View details for PubMedID 35989558

• On a scale from one to ten. Palliative & supportive care Smith, B. R. 2022: 1

  View details for DOI 10.1017/S1478951522000803

  View details for PubMedID 35735029

• Induction. Anesthesiology Smith, B. R. 2022

  View details for DOI 10.1097/ALN.0000000000004286

  View details for PubMedID 35727085

• Letter from a medical oncology scribe Palliative & Supportive Care Smith, B. R. 2022

  View details for DOI 10.1017/S1478951522000281

• On Diction. JAMA oncology Smith, B. R. 2021

  View details for DOI 10.1001/jamaoncol.2021.2730

  View details for PubMedID 34382997

• High-Parametric Evaluation of Human Invariant Natural Killer T Cells to Delineate Heterogeneity in Allo- and Autoimmunity. Blood Erkers, T., Xie, B., Kenyon, L. J., Smith, B., Rieck, M., Jensen, K. P., Ji, X., Basina, M., Strober, S., Negrin, R. S., Maecker, H. T., Meyer, E. 2020

  Abstract

  Human invariant natural killer T cells (iNKTs) are a rare innate-like lymphocyte population that recognize glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogenous and capable of enacting diverse functions, and the composition of iNKT subsets can alter disease outcomes. In contrast, far less is known about how heterogeneity in human iNKTs relates to disease. To address this, we use a high-dimensional, data-driven approach to devise a framework to parse human iNKT heterogeneity. Our data revealed novel and previously described iNKT phenotypes with distinct functions. In particular, we found two phenotypes of interest: 1) a population with Th1 function that was increased with iNKT activation characterized by HLA-II+CD161- expression, and 2) a population with enhanced cytotoxic function characterized by CD4-CD94+ expression. These populations, respectively, correlate with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and with new onset type 1 diabetes. Our study identifies human iNKT phenotypes associated with human disease that could aid in the development of biomarkers or therapeutics targeting iNKTs.

  View details for DOI 10.1182/blood.2019001903

  View details for PubMedID 31935280