Bio


At present, Cheng is working on the light-sound-molecule stimulation & imaging technology and the application to solve the key science questions in biomedicine, including (but are not limited to): 1) tumor microenvironment, 2) tumor angiogenesis. His core expertise includes 1) the stimulation and imaging techniques by using light and sound, 2) the design and applications of the novel biomolecules.

Cheng received his Ph.D. (2018) in biomedical engineering from the Hong Kong Polytechnic University (Hong Kong) under the supervision of Prof. Lei Sun. He was involved in the photoacoustic and ultrasound molecular imaging of the tumor microenvironment. After that, he moved to the Molecular Imaging Program at Stanford (MIPS) and spent one year as a postdoc working with Prof. Katherine Ferrara, where he learned the in vivo gene delivery technology by using the lipid nanoparticles. After that, he joined Prof. Jianghong Rao’s lab as a postdoc in 2019.

Cheng has been presented with several research awards from the World Molecular Imaging Society (WMIS), including Shark Tank Competition Finalist (WMIC2018), Industry Selected Poster Award (WMIC2017), Student Travel Stipend Award (WMIC2018 & 2017).

Honors & Awards


  • Shark Tank Competition Finalist, World Molecular Imaging Society (WMIS) (2018)
  • Student Travel Stipend Award (WMIC2018), World Molecular Imaging Society (WMIS) (2018)
  • Chinese Students Poster Competition Gold Award, World Molecular Imaging Congress (WMIC) (2017)
  • Industry Selected Poster Award (WMIC2017), World Molecular Imaging Society (WMIS) (2017)
  • Student Travel Stipend Award (WMIC2017), World Molecular Imaging Society (WMIS) (2017)
  • Best Poster Award, 2nd International Molecular Imaging Summit (IMIS), Xiamen, China PR (2015)
  • Student Travel Stipend, IEEE International Ultrasonics Symposium (IUS), Chicago, USA (2014)
  • Top Prize Student Research Award, Hong Kong Medical and Healthcare Device Industries Association (HKMHDIA) (2013)

Professional Education


  • Master of Philosophy, Hong Kong Polytechnic University (2014)
  • Doctor of Philosophy, Hong Kong Polytechnic University (2018)
  • Bachelor of Engineering, Unlisted School (2009)
  • Doctor of Philosophy, The Hong Kong Polytechnic University, Biomedical Engineering (2018)

Stanford Advisors


Patents


  • "United States Patent 62/640,101, Dkt. 2387-PRO ACTIVATABLE MULTISPECTRAL PHOTOACOUSTIC PROBES, METHODS OF MAKING PROBES, AND METHODS OF USE"

Current Research and Scholarly Interests


Molecular photoacoustic imaging; light-sound-molecule stimulation & imaging

Lab Affiliations


All Publications


  • Reversibly Photoswitching Upconversion Nanoparticles for Super-Sensitive Photoacoustic Molecular Imaging Angewandte Chemie International Edition (selected as the Very Important Paper (VIP)) Liu, C., Zheng, X., Dai, T., Wang, H., Chen, X., Chen, B., Sun, T., Wang, F., Chu, S., Rao, J. 2022

    View details for DOI 10.1002/anie.202116802

  • Quantitative characterization of the colorectal cancer in a rabbit model using high-frequency endoscopic ultrasound Ultrasonics Liu, C., Yang, Y., Qiu, W., Chen, Y., Dai, J., Sun, L. 2021; 110
  • Multispectral Photoacoustic Imaging of Tumor Protease Activity with a Gold Nanocage-Based Activatable Probe Molecular Imaging and Biology Liu, C., Li, S., Gu, Y., Xiong, H., Wong, W., Sun, L. 2018; 20: 919–929
  • Wrapping Porphyromonas gingivalis for tumor microenvironment immunomodulation and photothermal immunotherapy NANO TODAY Chen, Q., Liu, C., Liu, C., Zhong, D., Hua, S., He, J., Wang, K., Zhou, M. 2021; 41
  • Systemic Immunotherapy with Micellar Resiquimod-Polymer Conjugates Triggers a Robust Antitumor Response in a Breast Cancer Model. Advanced healthcare materials Kakwere, H. n., Zhang, H. n., Ingham, E. S., Nura-Raie, M. n., Tumbale, S. K., Allen, R. n., Tam, S. M., Wu, B. n., Liu, C. n., Kheirolomoom, A. n., Fite, B. Z., Ilovitsh, A. n., Lewis, J. S., Ferrara, K. W. 2021: e2100008

    Abstract

    Resiquimod is an immunopotent toll-like receptor 7/8 agonist with antitumor activity. Despite being potent against skin cancers, it is poorly tolerated systemically due to toxicity. Integrating resiquimod into nanoparticles presents an avenue to circumvent the toxicity problem. Herein, the preparation of degradable nanoparticles with covalently bound resiquimod and their systemic application in cancer immunotherapy is reported. Dispersion in water of amphiphilic constructs integrating resiquimod covalently bound via degradable amide or ester linkages yields immune-activating nanoparticles. The degradable agonist-nanoparticle bonds allow the release of resiquimod from the carrier nanoparticles. In vitro assays with antigen presenting cells demonstrate that the nanoparticles retain the immunostimulatory activity of resiquimod. Systemic administration of the nanoparticles and checkpoint blockade (aPD-1) to a breast cancer mouse model with multiple established tumors triggers antitumor activity evidenced by suppressed tumor growth and enhanced CD8+ T-cell infiltration. Nanoparticles with ester links, which hydrolyze more readily, yield a stronger immune response with 75% of tumors eliminated when combined with aPD-1. The reduced tumor growth and the presence of activated CD8+ T-cells across multiple tumors suggest the potential for treating metastatic cancer.

    View details for DOI 10.1002/adhm.202100008

    View details for PubMedID 33646600

  • InVivo Molecular Ultrasound Assessment of Glioblastoma Neovasculature with Endoglin-Targeted Microbubbles Contrast Media & Molecular Imaging Liu, C., Yan, F., Xu, Y., Zheng, H., Sun, L. 2018; 2018

    View details for DOI 10.1155/2018/8425495

  • A flexible annular-array imaging platform for micro-ultrasound IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control Qiu, W., Yu, Y., Chabok, H. R., Liu, C., Tsang, F., Zhou, Q., Shung, K., Zheng, H., Sun, L. 2013; 60 (1): 178 - 186

    View details for DOI 10.1109/TUFFC.2013.2548