
Daniel Owen Fishman
Clinical Assistant Professor, Psychiatry and Behavioral Sciences - Medical Psychiatry
Clinical Focus
- Psychiatry
Academic Appointments
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Clinical Assistant Professor, Psychiatry and Behavioral Sciences - Medical Psychiatry
Professional Education
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Board Certification: American Board of Psychiatry and Neurology, Consultation-Liason Psychiatry (2019)
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Fellowship: University of Pittsburgh Medical Center Psychiatry Program (2018) PA
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Board Certification: American Board of Psychiatry and Neurology, Psychiatry (2017)
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Residency: University of Pittsburgh Medical Center Psychiatry Program (2017) PA
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Medical Education: Vanderbilt University School of Medicine (2013) TN
All Publications
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Elevating the Care on Downers: Benzodiazepine Use Disorder in Patients With Cancer
WILEY. 2022: 53
View details for Web of Science ID 000765384800120
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Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism
NEURON
2011; 70 (5): 863-885
Abstract
We have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124 autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected parents, and, in most kindreds, an unaffected sibling. We find significant association of ASD with de novo duplications of 7q11.23, where the reciprocal deletion causes Williams-Beuren syndrome, characterized by a highly social personality. We identify rare recurrent de novo CNVs at five additional regions, including 16p13.2 (encompassing genes USP7 and C16orf72) and Cadherin 13, and implement a rigorous approach to evaluating the statistical significance of these observations. Overall, large de novo CNVs, particularly those encompassing multiple genes, confer substantial risks (OR = 5.6; CI = 2.6-12.0, p = 2.4 × 10(-7)). We estimate there are 130-234 ASD-related CNV regions in the human genome and present compelling evidence, based on cumulative data, for association of rare de novo events at 7q11.23, 15q11.2-13.1, 16p11.2, and Neurexin 1.
View details for DOI 10.1016/j.neuron.2011.05.002
View details for Web of Science ID 000291843500008
View details for PubMedID 21658581