Sylvia Elizabeth Villarreal Navarro

All Publications

• 40th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 18-20 September 2024, Copenhagen, Denmark Abstracts [Anonymous] SAGE PUBLICATIONS LTD. 2024: 4

  View details for DOI 10.1177/13524585241269218

  View details for Web of Science ID 001324906900001

• Longitudinal foveal adaptive optics scanning laser ophthalmoscopy in multiple sclerosis IOVS Hargrave, A., Buickians, D., Villarreal Navarro, S. E., Parthasarathi, P., Kipp, L., Han, M., Zavalla, G. A., Kowalski, B., Dubra, A., Moss, H. E. 2024
• Comparison of comorbidities in people with eye pain due to dry eye and eye pain due to other ocular causes in a tertiary care Neuro-Ophthalmolgy practice IOVS Parthasarathi, P., Moss, H. E., Villarreal Navarro, S. E. 2024
• In Vivo OCT Imaging of Müller and Macrophage-Like Cells in the Retinas of Patients with and without MS and related diseases IOVS Villarreal Navarro, S. E., Han, M., Kipp, L., Hargrave, A., Parthasarathi, P., Sylvestre-Bouchard, A., Dubra, A., Moss, H. E. 2024
• MSMilan2023-Oral Presentations Abstracts [Anonymous] SAGE PUBLICATIONS LTD. 2023: 4

  View details for DOI 10.1177/13524585231196191

  View details for Web of Science ID 001091311300001

• Chiasmal Injury in Silent Pituitary Apoplexy Without Evidence of Mass Effect. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Phansalkar, R., Navarro, S. E., Chiang, H., Moss, H. E. 2023

  View details for DOI 10.1097/WNO.0000000000001956

  View details for PubMedID 37459375

• Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks. American journal of ophthalmology Chen, J. J., Flanagan, E. P., Pittock, S. J., Stern, N. C., Tisavipat, N., Bhatti, M. T., Chodnicki, K. D., Tajfirouz, D. A., Jamali, S., Kunchok, A., Eggenberger, E. R., Nome, M. A., Sotirchos, E. S., Vasileiou, E. S., Henderson, A. D., Arnold, A. C., Bonelli, L., Moss, H. E., Navarro, S. E., Padungkiatsagul, T., Stiebel-Kalish, H., Lotan, I., Wilf-Yarkoni, A., Danesh-Meyer, H., Ivanov, S., Huda, S., Forcadela, M., Hodge, D., Poullin, P., Rode, J., Papeix, C., Saheb, S., Boudot de la Motte, M., Vignal, C., Hacohen, Y., Pique, J., Maillart, E., Deschamps, R., Audoin, B., Marignier, R. 2023

  Abstract

  To evaluate the effectiveness of plasma exchange (PLEX) for optic neuritis (ON).We conducted an international multicenter retrospective study evaluating the outcomes of ON following PLEX. Outcomes were compared to raw data from the Optic Neuritis Treatment Trial (ONTT) using a matched subset.A total of 395 ON attack treated with PLEX from 317 patients were evaluated. The median age was 37 years (range 9 to 75) and 71% were female. Causes of ON included: multiple sclerosis (108), myelin-oligodendrocyte-glycoprotein-antibody-associated-disease (MOGAD) (92), aquaporin-4-IgG-positive-neuromyelitis-optica-spectrum-disorder (AQP4+NMOSD) (75), seronegative-NMOSD (34), idiopathic (83), and other (3). Median time from onset of vision loss to PLEX was 2.6 weeks (IQR, 1.4-4.0). Median visual acuity (VA) at time of PLEX was count fingers (IQR, 20/200-hand motion) and median final VA was 20/25 (IQR, 20/20-20/60) with no differences among etiologies except MOGAD-ON which had better outcomes. In 81 (20.5%) ON attacks, the final VA was 20/200 or worse. Patients with poor outcomes were older (p=0.002), had worse VA at time of PLEX (p<0.001), and longer delay to PLEX (p<0.001). In comparison with the ONTT subset with severe corticosteroid-unresponsive ON, a final VA of worse than 20/40 occurred in 6/50 (12%) PLEX-treated ON versus 6/18 (33%) from the ONTT treated with intravenous methylprednisolone without PLEX (p=0.04).Most ON attacks improved with PLEX, and outcomes were better than attacks with similar severity in the ONTT. The presence of severe vision loss at nadir, older age, and longer delay to PLEX predicted a worse outcome while MOGAD-ON had a more favorable prognosis.

  View details for DOI 10.1016/j.ajo.2023.02.013

  View details for PubMedID 36822570

• Accuracy of International Classification of Diseases Codes for Identifying Acute Optic Neuritis. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Muro-Fuentes, E. A., Villarreal Navarro, S. E., Moss, H. E. 2023

  Abstract

  The accuracy of International Classification of Diseases (ICD) codes for identifying cases of acute optic neuritis (aON) is not known. A prior study reported 61% accuracy for ICD code plus MRI consistent with aON within 2 months. This study determined accuracy for ICD code plus MRI within 2 months regardless of results.Retrospective chart review was conducted using a medical record research repository of a tertiary care institution from 1998 to 2019. Subjects with ICD-9/10 codes for ON and an MRI brain and/or orbits within 2 months of earliest (initial) ICD code were included. MRI was classified as positive or negative for aON based on report noting gadolinium-contrast enhancement. Clinical diagnosis at the time of initial code was classified as aON, prior ON, considered ON, alternative diagnosis, or unknown based on review of physician authored clinical notes within 7 days of the initial code. Accuracy of ICD code for aON, acute or prior ON, and acute, prior, or considered ON were calculated for all subjects and stratified based on MRI result.Two hundred fifty-one subjects had MRI results within 2 months of their initial ON ICD code (49 positive MRI [previously reported]; 202 negative MRI). Among those with negative MRI, 32 (16%) had aON, 40 (20%) had prior ON, 19 (9%) considered ON as a diagnosis, 92 (46%) had other confirmed diagnoses, and 19 (9%) had unknown diagnosis at time of code. Considering all subjects, accuracy for ICD code was 25% for acute ON, 41% for acute or prior ON, and 48% for acute, prior, or considered ON. Positive MRI, increased number of ON ICD codes, a code given by an ophthalmologist or neurologist within 2 months, and the presence of a neurology encounter within 2 months were associated with an increased accuracy for clinical aON diagnosis.In the setting of an MRI within 2 months, ICD codes for ON have low accuracy for acute ON and only slightly better accuracy for acute or prior ON. Accuracy is higher for cases with a positive MRI than those with a negative MRI, suggesting positive MRI in conjunction with ICD codes may help more accurately identify cases. Reliance on ICD and Current Procedural Terminology codes alone to identify aON cases may introduce substantial misclassification bias in claims-based research.

  View details for DOI 10.1097/WNO.0000000000001805

  View details for PubMedID 36696226

• Longitudinal imaging of microscopic scattering features in the foveal avascular zone of multiple sclerosis using adaptive optics ophthalmoscopy IOVS Hargrave, A., Villarreal Navarro, S. E., Buickians, D., Kipp, L., Han, M., Kowalski, B., Dubra, A., Moss, H. E. 2023
• Trends in Trainee and Senior Author Gender for Abstracts Submitted to the NANOS 2019-2022 Annual Meetings NOVEL Villarreal Navarro, S., Escobedo, R., Moss, H. E. 2023
• Comparison of macular Macrophage Like Cell and Müller Cell Density in Patients with Multiple Sclerosis using OCT IOVS Villarreal Navarro, S. E., Soetikno, B., Hargrave, A., Buickians, D., Dubra, A., Moss, H. E. 2023
• Retinal Vessel Tortuosity Index as a Potential Biomarker of Idiopathic Intracranial Hypertension: Analysis of the IIH Treatment Trial IOVS Buickians, D., Villarreal Navarro, S. E., Moss, H., Feldon, S. E., Shahidi, M. 2023
• Secondary Rhinoplasty Using Autologous Rib Cartilage Journal of Otolaryngology and Rhinology Villarreal Navarro, S. E., et al 2020

  View details for DOI 10.23937/2572-4193.1510073

• Sudden Sensorineural Hearing Loss: An Updated Review American Journal of Otolaryngology and Head and Neck Surgery Villarreal Navarro, S. E., et al 2019