Academic Appointments

  • Clinical Assistant Professor, Medicine

Administrative Appointments

  • Associate Medical Education Director, Stanford ValleyCare (2022 - Present)

Boards, Advisory Committees, Professional Organizations

  • Member, Society of Hospital Medicine Education Committee (2020 - Present)

Professional Education

  • Board Certification, American Board of Internal Medicine (2018)
  • Residency, Stanford University (2018)
  • MD/MS, UC Berkeley-UCSF Joint Medical Program (2015)
  • BA, UC Berkeley, Interdisciplinary Studies (2009)

All Publications

  • Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma. Cancers Chen, V. J., Hernandez-Meza, G. n., Agrawal, P. n., Zhang, C. A., Xie, L. n., Gong, C. L., Hoerner, C. R., Srinivas, S. n., Oermann, E. K., Fan, A. C. 2019; 11 (7)


    With 15 drugs currently approved for the treatment of metastatic renal cell carcinoma (mRCC) and even more combination regimens with immunotherapy on the horizon, there remains a distinct lack of molecular biomarkers for therapeutic efficacy. Our study reports on real-world clinical outcomes of mRCC patients from a tertiary academic medical center treated with empirically selected standard-of-care therapy. We utilized the Stanford Renal Cell Carcinoma Database (RCCD) to report on various outcome measures, including overall survival (OS) and the median number of lines of targeted therapies received from the time of metastatic diagnosis. We found that most metastatic patients did not survive long enough to attempt even half of the available targeted therapies. We also noted that patients who failed to receive a clinical benefit within the first two lines of therapy could still go on to experience clinical benefit in later lines of therapy. The term, "clinical benefit" was assigned to a line of therapy if a patient remained on drug treatment for three months or longer. Moreover, patients with clinical benefit in at least one line of therapy experienced significantly longer OS compared to those who did not have clinical benefit in at least one line of therapy. Developing biomarkers that identify patients who will receive clinical benefit in individual lines of therapy is one potential strategy for achieving rational drug sequencing in mRCC.

    View details for DOI 10.3390/cancers11071000

    View details for PubMedID 31319594

  • Reducing Telemetry Use Is Safe: A Retrospective Analysis of Rapid Response Team and Code Events After a Successful Intervention to Reduce Telemetry Use. American journal of medical quality : the official journal of the American College of Medical Quality Xie, L., Garg, T., Svec, D., Hom, J., Kaimal, R., Ahuja, N., Barnes, J., Shieh, L. 2018: 1062860618805189


    Interventions guiding appropriate telemetry utilization have successfully reduced use at many hospitals, but few studies have examined their possible adverse outcomes. The authors conducted a successful intervention to reduce telemetry use in 2013 on a hospitalist service using educational modules, routine review, and financial incentives. The association of reduced telemetry use with the incidence of rapid response team (RRT) and code activations was assessed in a retrospective cohort study of 210 patients who experienced a total of 233 RRT and code events on the inpatient internal medicine services from January 2012 through March 2015 at a tertiary care center. The incidence of adverse events for the hospitalist service was not significantly different during the intervention and postintervention period as compared to the preintervention period. Reducing inappropriate telemetry use was not associated with an increase in the incidence rates of RRT and code events.

    View details for PubMedID 30293436

  • Shared Decision-Making During Inpatient Rounds: Opportunities for Improvement in Patient Engagement and Communication JOURNAL OF HOSPITAL MEDICINE Blankenburg, R., Hilton, J. F., Yuan, P., Rennke, S., Monash, B., Harman, S. M., Sakai, D. S., Hosamani, P., Khan, A., Chua, I., Huynh, E., Shieh, L., Xie, L., Satterfield, J. M. 2018; 13 (7): 453–61

    View details for DOI 10.12788/jhm.2909

    View details for Web of Science ID 000437294500002

  • Domestic Violence Counseling in Rural Northern China: Gender, Social Harmony, and Human Rights VIOLENCE AGAINST WOMEN Xie, L., Eyre, S. L., Barker, J. 2018; 24 (3): 307–21


    Domestic violence (DV) affects over a third of Chinese women in a relationship. Focusing on ethnographic data from six staff members and six DV survivors at a rural, state-affiliated women's center in China in 2010, this article relies on Henrietta Moore's notion of the poststructuralist gendered subject to examine how the staff draw on discourses about gender and social harmony in persuading women to stay in their marriages, rather than on human rights discourses that emphasize survivor safety. It shows that DV survivors are frequently sent back to dangerous homes where their health is placed at risk.

    View details for PubMedID 29332527

  • Scedosporium apiospermum infection of the urinary system with a review of treatment options and cases in the literature TRANSPLANT INFECTIOUS DISEASE Benamu, E., Yu, A., Xie, L., Fernandez-Pol, S., Liu, A. Y., Ho, D. Y. 2018; 20 (1)


    Infection with Scedosporium species is associated with a significant morbidity and mortality and is becoming increasingly common, especially in immunocompromised patients. We describe the presentation and successful management of an immunocompromised patient with Scedosporium apiospermum infection of the upper urinary tract system, a rare disease manifestation. The current literature on urinary tract scedosporiosis is further reviewed with emphasis on treatment options and limitations of current antifungal therapy.

    View details for PubMedID 29111602

    View details for PubMedCentralID PMC5871223

  • Osimertinib for EGFR-Mutant Lung Cancer with Brain Metastases: Results from a Single-Center Retrospective Study. The oncologist Xie, L. n., Nagpal, S. n., Wakelee, H. A., Li, G. n., Soltys, S. G., Neal, J. W. 2018


    Osimertinib is a third-generation tyrosine kinase inhibitor, initially approved for epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) with T790M acquired resistance, and now approved in the first-line setting. However, data supporting the use of osimertinib in untreated brain metastases are limited, although it has established central nervous system (CNS) activity. Our study compares the clinical outcomes of patients experiencing progressing brain metastases treated with cranial irradiation and osimertinib with those treated with osimertinib alone.Forty patients who were treated with osimertinib at the Stanford Cancer Center from November 2015 to December 2016 were identified by searching an electronic medical record database. Eleven patients had progressing brain metastases and did not receive radiation (group A), 9 patients had progressing brain metastases and received radiation when starting osimertinib (group B), and 20 patients had stable brain metastases at the time of initiating osimertinib (group C). Patient and disease characteristics, radiographic responses, and survival outcomes were evaluated retrospectively for the three groups.The CNS response rate was 32.3%. Median time to treatment failure (TTF), overall progression-free survival (PFS), and overall survival (OS) were 10.0 months (95% confidence interval [CI], 4.5-11.8), 8.8 months (95% CI, 6.2-12.1), and 16.2 months, respectively. Median TTF was 15.1 months for group A (95% CI, 1.7-28.5), 7.7 months for group B (95% CI, 0-15.5), and 10.7 months for group C (95% CI, 9.0-12.5). The median PFS was 8.8 months for group A (95% CI, 4.3-13.4), not reached for group B, and 8.4 months for group C (95% CI, 5.6-11.1). The median OS was not reached for group A and C, and was 16.2 months for group B. There was no apparent difference in TTF, PFS, or OS between the three groups.Receiving radiation prior to starting osimertinib for patients with progressing brain metastases did not prolong TTF, PFS, or OS in our series. To minimize the risks of radiation-related toxicity, delaying radiation could be considered for some patients with EGFR-mutant NSCLC with brain metastases who initially respond to osimertinib in the second-line setting.Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor recently approved for the first-line treatment of EGFR-mutant non-small cell lung cancer. Although it appears to have central nervous system (CNS) activity, most clinical trials have excluded patients with untreated, progressing brain metastases. This study included patients with stable and progressing CNS metastases treated with osimertinib and found no apparent differences in median time to treatment failure, time to progression, and overall survival in patients who received osimertinib alone compared with those who received osimertinib and radiosurgery. This may support a clinician's decision to defer radiation for selected patients with untreated brain metastases who are candidates for osimertinib therapy.

    View details for PubMedID 30126856

  • GOT SDM?: A MULTIMODAL INTERVENTION TO IMPROVE SHARED DECISION-MAKING DURING INPATIENT ROUNDS ON MEDICINE AND PEDIATRIC SERVICES Blankenburg, R., Rennke, S., Sakai, D. S., Harman, S. M., Yuan, P., Hosamani, P., Xie, L., Shieh, L., Chua, I., Khan, A., Huynh, E., Satterfield, J., Monash, B. SPRINGER. 2016: S233–S234
  • SHARED DECISION MAKING DURING INPATIENT ROUNDS: OPPORTUNITIES FOR BEHAVIORAL MEDICINE TO IMPROVE COMMUNICATION Satterfield, J., Blankenburg, R., Monash, B., Yuan, P., Harman, S., Hilton, J. F., Sakai, D. S., Chua, I., Huynh, E., Hosamani, P., Khan, A., Shieh, L., Xie, L., Reinke, S. OXFORD UNIV PRESS INC. 2016: S298
  • SHARED DECISION-MAKING DURING INPATIENT ROUNDS: DISSIMILAR YET CORRELATED PERSPECTIVES OF PATIENTS/GUARDIANS AND PHYSICIAN OBSERVERS Rennke, S., Monash, B., Blankenburg, R., Yuan, P., Harman, S. M., Hilton, J. F., Sakai, D. S., Chua, I., Huynh, E., Hosamani, P., Khan, A., Shieh, L., Xie, L., Satterfield, J. SPRINGER. 2015: S252