Andrew Sullivan
Ph.D. Student in Physics, admitted Autumn 2022
All Publications
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Determining the Hubble constant with AGN-assisted black hole mergers
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
2024; 531 (3): 3679-3683
View details for DOI 10.1093/mnras/stae1360
View details for Web of Science ID 001245480800008
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Small-scale radio jets and tidal disruption events: a theory of high-luminosity compact symmetric objects
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
2024; 528 (4): 6302-6311
View details for DOI 10.1093/mnras/stae322
View details for Web of Science ID 001169271500006
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Gamma-ray burst precursors from tidally resonant neutron star oceans: potential implications for GRB 211211A
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
2024; 527 (3): 7722-7730
View details for DOI 10.1093/mnras/stad3572
View details for Web of Science ID 001131511000109
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Polarization of Intrabinary Shock Emission in Spider Pulsars
ASTROPHYSICAL JOURNAL
2023; 959 (2)
View details for DOI 10.3847/1538-4357/ad09ae
View details for Web of Science ID 001116566800001
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Probing the dark Solar system: detecting binary asteroids with a space-based interferometric asteroid explorer
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
2022; 512 (3): 3738-3753
View details for DOI 10.1093/mnras/stac669
View details for Web of Science ID 000778361300008
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Search for Black Hole Merger Families
ASTROPHYSICAL JOURNAL LETTERS
2021; 907 (2)
View details for DOI 10.3847/2041-8213/abd721
View details for Web of Science ID 000614787700001
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Can we use next-generation gravitational wave detectors for terrestrial precision measurements of Shapiro delay?
CLASSICAL AND QUANTUM GRAVITY
2020; 37 (20)
View details for DOI 10.1088/1361-6382/abb260
View details for Web of Science ID 000574337700001
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Have hierarchical three-body mergers been detected by LIGO/Virgo?
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
2020; 498 (1): L46-L52
View details for DOI 10.1093/mnrasl/slaa123
View details for Web of Science ID 000587744400010
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Attracting Opposites: Promiscuous Ion-pi Binding in the Nucleobases
JOURNAL OF PHYSICAL CHEMISTRY A
2020; 124 (20): 4128-4140
Abstract
Ion-π interactions between the face of a molecular π-system and a cation or anion are among the strongest noncovalent interactions known, with applications throughout biochemistry and structural biology, molecular recognition and host-guest chemistry, as well as enzyme kinetics and organocatalysis. In this work, we examine the competing notions of selectivity and flexibility in this class of noncovalent interactions by investigating how certain π-systems can be promiscuous ion-π binders with the versatility to form favorable cation- and anion-π complexes. We focus our efforts on a detailed theoretical case study of the DNA/RNA nucleobases by first demonstrating that these π-systems are promiscuous ion-π binders with the biologically relevant Li+/Na+ cations and F-/Cl- anions via benchmark-quality quantum-mechanical binding energy curves computed at the CCSD(T)/CBS level of theory. Using a symmetry-adapted perturbation theory (SAPT)-based energy decomposition analysis, we explore the different physicochemical driving forces underlying the formation of cation- and anion-π complexes, as well as the crucial role played by charge penetration effects in determining the nontrivial (and often counterintuitive) electrostatics in anion-π systems. In doing so, a unified view of these rather distinct noncovalent binding motifs emerges with the finding that both cation- and anion-π complexes are strongly stabilized by an essentially ring-independent potential that can only be overcome by substantially unfavorable electrostatics. This work furnishes a more comprehensive explanation for decades of observed correlations between the equilibrium binding energy and the electrostatic potential above the ring and provides new insight into the nature of selectivity and flexibility in this important class of noncovalent interactions. Quite interestingly, the analysis presented herein demonstrates that π-systems have an inherent propensity to bind both cations and anions, thereby implying that promiscuous ion-π binding is not an exotic property of the nucleobases and should be common in nature.
View details for DOI 10.1021/acs.jpca.0c02766
View details for Web of Science ID 000537424600018
View details for PubMedID 32227907