Clinical Focus


  • Nephrology
  • Transplant Nephrology

Academic Appointments


Professional Education


  • Fellowship, Stanford University, Transplant Nephrology, CA (2024)
  • Board Certification: American Board of Internal Medicine, Nephrology (2023)
  • MAS, University of California San Francisco, Clinical Research, CA (2023)
  • Fellowship, University of California San Francisco, Nephrology, CA (2023)
  • Board Certification: American Board of Internal Medicine, Internal Medicine (2022)
  • Residency, Massachusetts General Hospital, Internal Medicine, MA (2020)
  • Medical Education: Harvard Medical School (2017) MA

All Publications


  • Association between English Proficiency and Kidney Disease Knowledge and Communication Quality among Patients with ESKD. Kidney360 Martinez, A., Warner, A., Powe, N. R., Fernandez, A., Tuot, D. S. 2024

    Abstract

    End stage kidney disease (ESKD) is a chronic health condition for which communication between health care teams and patients is important to guide patient self-management activities. Yet little is known about quality of communication among patients with ESKD and their care team members. We examined the influence of patient's LEP status on communication experiences at one dialysis center.A survey was administered to adults receiving ESKD care at a dialysis unit within a public health care delivery system between July 2022 and February 2023, to ascertain kidney disease knowledge and perceptions of communication quality with the dialysis care team. Multivariable logistic and ordinal logistic regression models adjusted for age and gender were used to determine associations between LEP status and CKD knowledge.Among 93 eligible patients, 88.2% (n=82) completed the survey. Approximately 37.8% (n=31) had LEP, mean age was 58.8 years, 68.3% were men, mean dialysis vintage was 3.9 years, and 25% had a positive depression screen (LEP 30%; English-proficient 22%). A higher proportion of English-proficient patients screened positive for limited health literacy compared to those with LEP (74.5% vs 38.7%, p=0.002). Overall, knowledge of assigned cause of ESKD (53.4%) and CKD/transplant knowledge (57.3%) was suboptimal. After adjustment, LEP status was not significantly associated with knowing the correct cause of kidney failure (OR=0.49, 95% CI 0.19-1.27) but was significantly associated with having a higher score on a CKD/transplant knowledge scale (OR 3.99, 95% CI 1.66-9.58). Patients with LEP reported poorer communication quality with dialysis providers and staff (less listening, fewer clear explanations, less time spent with patients) compared to English-proficient patients, though differences were not statistically significant.Overall communication between patients with ESKD and members of the dialysis care team was suboptimal, regardless of English proficiency. Interventions to enhance communication for ESKD patients are needed.

    View details for DOI 10.34067/KID.0000000000000398

    View details for PubMedID 38356152

  • Validity of the Spanish-Language Patient Health Questionnaires 2 and 9: A Systematic Review and Meta-Analysis. JAMA network open Martinez, A., Teklu, S. M., Tahir, P., Garcia, M. E. 2023; 6 (10): e2336529

    Abstract

    Reliable screening for major depressive disorder (MDD) relies on valid and accurate screening tools.To examine the validity, accuracy, and reliability of the Spanish-language Patient Health Questionnaires 2 and 9 (PHQ-2 and PHQ-9) to screen for MDD.PubMed, Web of Science, Embase, and PsycINFO from data initiation through February 27, 2023.English- and Spanish-language studies evaluating the validity of the Spanish-language PHQ-2 or PHQ-9 in screening adults for MDD compared with a standardized clinical interview (gold standard). Search terms included PHQ-2, PHQ-9, depression, and Spanish.Two reviewers performed abstract and full-text reviews, data extraction, and quality assessment. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Random-effects meta-analyses of sensitivity, specificity, and area under the curve (AUC) were performed. Internal consistency was evaluated using Cronbach α and McDonald ψ.Test accuracy and internal consistency. The PHQ-2 is composed of the first 2 questions of the PHQ-9 (targeting core depression symptoms of depressed mood and anhedonia; a score of 3 or higher (score range, 0-6) is generally considered a positive depression screen. If a patient screens positive with the PHQ-2, a follow-up assessment with the PHQ-9 and a clinical diagnostic evaluation are recommended. Once depression is diagnosed, a PHQ-9 score of 10 or higher (score range, 0-27) is often considered an acceptable threshold for treating depression.Ten cross-sectional studies involving 5164 Spanish-speaking adults (mean age range, 34.1-71.8 years) were included; most studies (n = 8) were in primary care settings. One study evaluated the PHQ-2, 7 evaluated the PHQ-9, and 2 evaluated both the PHQ-2 and PHQ-9. For the PHQ-2, optimal cutoff scores ranged from greater than or equal to 1 to greater than or equal to 2, with an overall pooled sensitivity of 0.89 (95% CI, 0.81-0.95), overall pooled specificity of 0.89 (95% CI, 0.81-0.95), and overall pooled AUC of 0.87 (95% CI, 0.83-0.90); Cronbach α was 0.71 to 0.75, and McDonald ψ was 0.71. For the PHQ-9, optimal cutoff scores ranged from greater than or equal to 5 to greater than or equal to 12, with an overall pooled sensitivity of 0.86 (95% CI, 0.82-0.90), overall pooled specificity of 0.80 (95% CI, 0.75-0.85), and overall pooled AUC of 0.88 (95% CI, 0.87-0.90); Cronbach α was 0.78 to 0.90, and McDonald ψ was 0.79 to 0.90. Four studies were considered to have low risk of bias; 6 studies had indeterminate risk of bias due to a lack of blinding information.In this systematic review and meta-analysis, limited available evidence supported the use of the Spanish-language PHQ-2 and PHQ-9 in screening for MDD, but optimal cutoff scores varied greatly across studies, and few studies reported on blinding schemes. These results suggest that MDD should be considered in Spanish-speaking individuals with lower test scores. Given the widespread clinical use of the tools and the heterogeneity of existing evidence, further investigation is needed.

    View details for DOI 10.1001/jamanetworkopen.2023.36529

    View details for PubMedID 37847505

    View details for PubMedCentralID PMC10582786