Ning Lu received a joint Ph.D. degree in Biomedical Engineering and Scientific Computing from the University of Michigan, Ann Arbor, USA, in 2023. Previously, she earned a B.S.E. degree (highest honors) in Biomedical Engineering from Southeast University, Nanjing, China, in 2018. From May 2022 to September 2022, she worked at Meta (formerly Facebook) Reality Labs as a research scientist intern on ultrasonic eye tracking for AR/VR wearable devices, in Redmond, Washington, USA. Her research interests include ultrasound instrumentation, ultrasound therapy, ultrasound imaging algorithms, and AI in healthcare.

Stanford Advisors

All Publications

  • Neuronavigation-Guided Transcranial Histotripsy (NaviTH) System. Ultrasound in medicine & biology Choi, S. W., Komaiha, M., Choi, D., Lu, N., Gerhardson, T. I., Fox, A., Chaudhary, N., Camelo-Piragua, S., Hall, T. L., Pandey, A. S., Xu, Z., Sukovich, J. R. 2024


    The goal of the work described here was to develop the first neuronavigation-guided transcranial histotripsy (NaviTH) system and associated workflow for transcranial ablation.The NaviTH system consists of a 360-element, 700 kHz transmitter-receiver-capable transcranial histotripsy array, a clinical neuronavigation system and associated equipment for patient-to-array co-registration and therapy planning and targeting software systems. A workflow for NaviTH treatments, including pre-treatment aberration correction, was developed. Targeting errors stemming from target registration errors (TREs) during the patient-to-array co-registration process, as well as focal shifts caused by skull-induced aberrations, were investigated and characterized. The NaviTH system was used in treatments of two <96 h post-mortem human cadavers and in experiments in two excised human skullcaps.The NaviTH was successfully used to create ablations in the cadaver brains as confirmed in post-treatment magnetic resonance imaging A total of three ablations were created in the cadaver brains, and targeting errors of 9, 3.4 and 4.4 mm were observed in corpus callosum, septum and thalamus targets, respectively. Errors were found to be caused primarily by TREs resulting from transducer tracking instrument design flaws and imperfections in the treatment workflow. Transducer tracking instrument design and workflow improvements reduced TREs to <2 mm, and skull-induced focal shifts, following pre-treatment aberration correction, were 0.3 mm. Total targeting errors of the NaviTH system following the noted improvements were 2.5 mm.The feasibility of using the first NaviTH system in a human cadaver model has been determined. Although accuracy still needs to be improved, the proposed system has the potential to allow for transcranial histotripsy therapies without requiring active magnetic resonance treatment guidance.

    View details for DOI 10.1016/j.ultrasmedbio.2024.04.001

    View details for PubMedID 38789304