Doctor, University Paris XI, Neuroscience (2016)
Master of Science, Universite De Paris Xi (Paris-Sud) (2012)
Licence, Universite De Caen (2010)
Diplom, Unlisted School (2009)
H Heller, Postdoctoral Faculty Sponsor
- The Mouse Gambling Task: Assessing Individual Decision-making Strategies in Mice BIO-PROTOCOL 2020; 10 (1)
Suprachiasmatic lesions restore object recognition in down syndrome model mice.
Neurobiology of sleep and circadian rhythms
2020; 8: 100049
The Ts65Dn mouse is a well-studied model of trisomy 21, Down syndrome. This mouse strain has severe learning disability as measured by several rodent learning tests that depend on hippocampal spatial memory function. Hippocampal long-term potentiation (LTP) is deficient in these mice. Short-term daily treatment with low-dose GABA receptor antagonists rescue spatial learning and LTP in Ts65Dn mice leading to the hypothesis that the learning disability is due to GABAergic over-inhibition of hippocampal circuits. The fact that the GABA receptor antagonists were only effective if delivered during the daily light phase suggested that the source of the excess GABA was controlled directly or indirectly by the circadian system. The central circadian pacemaker of mammals is the suprachiasmatic nucleus (SCN), which is largely a GABAergic nucleus. In this study we investigated whether elimination of the SCN in Ts65Dn mice would restore their ability to form recognition memories as tested by the novel object recognition (NOR) task. Full, but not partial lesions of the SCN of Ts65Dn mice normalized their ability to perform on the NOR test. These results suggest that the circadian system modulates neuroplasticity over the time frame involved in the process of consolidation of recognition memories.
View details for DOI 10.1016/j.nbscr.2020.100049
View details for PubMedID 32195448
View details for PubMedCentralID PMC7075983
- One week of chronic sleep debt does not affect decision-making processes in a mouse version of the Iowa Gambling Task. BioRxiv 2019
Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes.
Sleep loss is associated with sleepiness, sustained attention, and memory deficits. However, vulnerability of higher cognitive processes (i.e. decision making) to sleep debt is less understood. Therefore, a major challenge is to understand why and how higher cognitive processes are affected by sleep debt. We had established in mice correlations between individual decision-making strategies, prefrontal activity, and regional monoaminergic levels. Now, we show that acute sleep debt (ASD) disturbs decision-making processes and provokes brain regional modifications of serotonin and dopamine that could explain why ASD promotes inflexible and more risk-prone behaviors. Finally, we highlight, for the first time, that in a large group of healthy inbred mice some of them are more sensitive to ASD by showing inflexible behavior and decision-making deficits. We were also able to predict mice that would be the most vulnerable to ASD depending of their behavior before ASD exposure.
View details for PubMedID 30304537
- Dissociated features of social cognition altered in mice schizophrenia models: focus on social dominance and acoustic communication Neuropharm 2018; 159 (107334)
- War pediatrics: epidemiologic characteristics of admissions on the critical care unit of the medical and surgical French hospital in Kabul. Anesthésie & Réanimation 2017; 3(5):426-432
- Nicotinic receptors are crucial for tuning of E/I balance in prelimbic cortex and for gambling performance in mouse. Frontiers in Psychiatry 2016: 7:17.
- Social behaviors and acoustic social communication in different strains of mice Behavioral Brain Research 2016; 320:383-390
- Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice. Brain Struct Funct. 2016; 221(9):4615-4629.
- Mice gamble for food: individual differences in risky choices and prefrontal cortex serotonin . J Addict Res Ther. 2013; S4:011