Adam Jacob Krause

All Publications

• Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Krause, A. J., Osorno, R., Solomon, N. L., Ahmadi, M., Lam, P., Magana, O., Blozyte-Sakenis, E., Harris, L. N., Babros, M. C., Izabel, S. S., Bernert, R. A., Williams, L. M., Gross, J. J., Ma, J., Lazzeroni, L. C., Yesavage, J. A., Manber, R., Saletin, J. M., Goldstein-Piekarski, A. N. 2026

  Abstract

  Treating insomnia with Cognitive-Behavioral Therapy for Insomnia (CBT-I) improves depression symptoms, but the underlying mechanisms remain unknown. This single-arm mechanistic trial (ClinicalTrials.gov, NCT04424407) examined fronto-limbic and sleep mechanisms of CBT-I's antidepressant response in 48 participants (64% female; age 25-60) with insomnia and depression symptoms. Participants completed functional magnetic resonance imaging (fMRI), polysomnography (PSG), and symptom assessments before and after 6 CBT-I sessions. CBT-I resulted in reduced amygdala reactivity to fearful faces (d = 0.55, p = 0.008). Depression and sleep (objective and self-reported insomnia symptoms also improved. However, fMRI-assessed fronto-limbic changes were not associated with a reduction of depressive symptom severity. Instead, reduced depressive symptoms correlated with reduced self-reported insomnia symptoms (p = 0.001, η2p = 0.19) and increased objective sleep efficiency (p = 0.04, η2p = 0.10). Notably, pre-treatment PSG-assessed sleep efficiency, but not fronto-limbic function nor insomnia symptoms, predicted reduced depressive symptoms (p = 0.007, η2p = 0.16), suggesting that lower objective sleep efficiency prior to treatment may be associated with greater antidepressant benefit from CBT-I.

  View details for DOI 10.1038/s41386-026-02431-0

  View details for PubMedID 42098309

  View details for PubMedCentralID 1978360

• EXAMINING FRONTO-LIMBIC BRAIN AND SLEEP MECHANISMS OF ANTI-DEPRESSANT EFFECTS IN COGNITIVE-BEHAVIORAL THERAPY FOR INSOMNIA Krause, A., Osorno, R., Solomon, N., Ahmadi, M., Lam, P., Magana, O., Blozyte, E., Izabel, S., Bernert, R., Williams, L., Gross, J., Ma, J., Lazzeroni, L., Yesavage, J., Manber, R., Saletin, J., Piekarski, A. SPRINGERNATURE. 2026

  View details for Web of Science ID 001665758000385

• Objective Sleep, Internalizing Symptoms, and Emotion Regulation in Adolescents: Findings from the ABCD Study Izabel, S., Kiss, O., Krause, A., Hunt, E. T., Potter, A., Johnson, M., Dube, S. L., Allgaier, N., Garavan, H., Goldstein-Piekarski, A. OXFORD UNIV PRESS INC. 2025: A458

  View details for DOI 10.1093/sleep/zsaf090.1059

  View details for Web of Science ID 001490486200016

• Associations Between Objectively Sleep Duration, Night-To-Night Variability, and Sleep Onset With Emotion Regulation and Internalizing Symptoms in Adolescents: Findings From the ABCD Study Izabel, S., Kiss, O., Krause, A., Hunt, E. T., Potter, A., Johnson, M., Dube, S., Allgaier, N., Garavan, H., Goldstein-Piekarski, A. ELSEVIER SCIENCE INC. 2025

  View details for Web of Science ID 001500622300111

• Insomnia Intervention is Associated With Changing Dorsolateral Prefrontal Cortex Activity in Depression Wang, Z., Krause, A. J., Osorno, R., Solomon, N., Bernert, R., Williams, L., Gross, J., Ma, J., Lazzeroni, L., Yesavage, J., Manber, R., Goldstein-Piekarski, A. ELSEVIER SCIENCE INC. 2025

  View details for Web of Science ID 001491712900069

• Insomnia Intervention Associated With Improvements in Affective Brain Function and Mood in Depression Krause, A., Osorno, R., Solomon, N., Ahmadi, M., Lam, P., Magana, O., Blozyte, E., Cirelli, A., Harris, L., Izabel, S., Bernert, R., Williams, L., Gross, J., Ma, J., Lazzeroni, L., Yesavage, J., Manber, R., Saletin, J., Goldstein-Piekarski, A. ELSEVIER SCIENCE INC. 2025

  View details for Web of Science ID 001500622200108

• Insomnia Intervention Associated with Improvements in Affective Brain Function, Mood, and Sleep in Depression Krause, A., Osorno, R., Solomon, N., Ahmadi, M., Lam, P., Magana, O., Blozyte, E., Harris, L., Gross, J., Ma, J., Lazzeroni, L., Yesavage, J., Manber, R., Saletin, J., Goldstein-Piekarski, A. OXFORD UNIV PRESS INC. 2025: A521

  View details for DOI 10.1093/sleep/zsaf090.1207

  View details for Web of Science ID 001490501500013

• Modifying the Emotion Regulation Brain Network in Depression: Mechanistic Insights From a Clinical Trial of Cognitive-Behavioral Therapy for Insomnia Krause, A., Izabel, S., Osorno, R., Solomon, N., Ahmadi, M., Lam, P., Magana, O., Blozyte, E., Cirelli, A., Harris, L., Bernert, R., Williams, L., Gross, J., Ma, J., Lazzeroni, L., Yesavage, J., Manber, R., Saletin, J., Goldstein-Piekarski, A. SPRINGERNATURE. 2023: 208-209

  View details for Web of Science ID 001184093500400

• Daytime affect and sleep EEG activity: A data-driven exploration. Journal of sleep research Zhang, J. X., Ten Brink, M., Yan, Y., Goldstein-Piekarski, A., Krause, A. J., Manber, R., Kreibig, S., Gross, J. J. 2023: e13916

  Abstract

  It has long been thought that links between affect and sleep are bidirectional. However, few studies have directly assessed the relationships between: (1) pre-sleep affect and sleep electroencephalogram (EEG) activity; and (2) sleep EEG activity and post-sleep affect. This study aims to systematically explore the correlations between pre-/post-sleep affect and EEG activity during sleep. In a community sample of adults (n = 51), we measured participants' positive and negative affect in the evening before sleep and in the next morning after sleep. Participants slept at their residence for 1 night of EEG recording. Using Fourier transforms, the EEG power at each channel was estimated during rapid eye movement sleep and non-rapid eye movement sleep for the full range of sleep EEG frequencies. We first present heatmaps of the raw correlations between pre-/post-sleep affect and EEG power during rapid eye movement and non-rapid eye movement sleep. We then thresholded the raw correlations with a medium effect size |r| ≥ 0.3. Using a cluster-based permutation test, we identified a significant cluster indicating a negative correlation between pre-sleep positive affect and EEG power in the alpha frequency range during rapid eye movement sleep. This result suggests that more positive affect during the daytime may be associated with less fragmented rapid eye movement sleep that night. Overall, our exploratory results lay the foundation for confirmatory research on the relationship between daytime affect and sleep EEG activity.

  View details for DOI 10.1111/jsr.13916

  View details for PubMedID 37156757

• Improvements in Immediate and Delayed Memory With Insomnia Therapy and Their Associations With SWA in Older Adults Ahmadi, M., Krause, A. J., O'Hora, K. P., Hernandez, B., Lazzeroni, L., Zeitzer, J. M., Friedman, L. F., Posner, D., Kushida, C. A., Yesavage, J. A., Saletin, J., Goldstein-Piekarski, A. ELSEVIER SCIENCE INC. 2023: S301

  View details for Web of Science ID 000993018500730

• Pre-sleep affect predicts subsequent REM frontal theta in nonlinear fashion. Cognitive, affective & behavioral neuroscience Ten Brink, M., Yan, Y., Zhang, J., Goldstein-Piekarski, A., Krause, A., Kreibig, S., Manber, R., Gross, J. 2023

  Abstract

  Pre-sleep affect is thought to influence sleep, but associations with both sleep architecture and the electroencephalographic (EEG) power spectrum are mixed. In this pre-registered study, we assessed negative valence and arousal 1h pre-sleep in 52 adults drawn from the community, then recorded one night of polysomnography (PSG) in participants' own homes. Pre-sleep affect was not associated with nonrapid eye movement (NREM) or rapid eye movement (REM) sleep architecture parameters, but we did observe inverted U-shaped relationships between both negative valence and arousal and REM frontal theta power, such that theta power was highest at moderate negative valence and arousal, and lowest at either affective extreme. When entered into a model together, both valence and arousal accounted for independent variance. Secondary analyses revealed a similar quadratic association with pre-sleep positive valence, suggesting a nonspecific effect of pre-sleep valence on REM frontal theta. Robustness checks confirmed that effects were not explained by homeostatic sleep pressure or sleep timing. Our results suggest that mixed findings in the literaturemay reflect different ends of a quadratic function, underscoring the importance of assessing how different components of pre-sleep affect relate to sleep.

  View details for DOI 10.3758/s13415-022-01051-7

  View details for PubMedID 36702991

• EXAMINING THE ASSOCIATION OF TRAIT SLEEP REACTIVITY WITH CHANGES IN SLEEP, DEPRESSION, AND ANXIETY IN THE COVID-19 PANDEMIC Cirelli, A., Krause, A., O'Hora, K., Osorno, R., Sadeghi-Bahmani, D., Lopez, M., Morehouse, A., Goldstein-Piekarski, A. OXFORD UNIV PRESS INC. 2022: A21

  View details for Web of Science ID 000838094800045

• NON-PHARMACOLOGICAL INSOMNIA THERAPY IS ROBUST TO CO-OCCURRING PAIN IN OLDER ADULTS Krause, A., Ahmadi, M., O'Hora, K., Hernandez, B., Lazzeroni, L., Zeitzer, J., Friedman, L., Posner, D., Kushida, C., Yesavage, J., Saletin, J., Goldstein-Piekarski, A. OXFORD UNIV PRESS INC. 2022: A197-A198

  View details for Web of Science ID 000838094800441

• THE EFFECT OF DISTINCT COMPONENTS OF CBT-I ON SLOW WAVE POWER AND ENERGY Ahmadi, M., Krause, A., O'Hora, K., Hernandez, B., Lazzeroni, L., Zeitzer, J., Friedman, L., Posner, D., Kushida, C., Yesavage, J., Saletin, J., Goldstein-Piekarski, A. OXFORD UNIV PRESS INC. 2022: A197

  View details for Web of Science ID 000838094800440

• THE IMPACT OF NON-PHARMACOLOGICAL INSOMNIA THERAPY ON MOOD AND SLEEP IN MORNING AND EVENING CHRONOTYPES IN OLDER ADULTS Lopez, M., Krause, A., O'Hora, K., Hernandez, B., Lazzeroni, L., Zeitzer, J., Friedman, L., Posner, D., Kushida, C., Yesavage, J., Goldstein-Piekarski, A. OXFORD UNIV PRESS INC. 2022: A211-A212

  View details for Web of Science ID 000838094800474

• PHYSICAL ACTIVITY AND SLEEP PATTERNS BEFORE AND DURING THE COVID-19-PANDEMIC - RESULTS FROM A CROSS-SECTIONAL AND RETROSPECTIVE STUDY Sadeghi-Bahmani, D., O'Hora, K., Osorno, R., Lopez, M., Morehouse, A., Krause, A., Goldstein-Piekarski, A. OXFORD UNIV PRESS INC. 2022: A303

  View details for Web of Science ID 000838094800687

• Non-Pharmacological Insomnia Therapy is Robust to Co-Occurring Pain in Older Adults Krause, A., Ahmadi, M., O'Hora, K., Hernandez, B., Lazzeroni, L., Zeitzer, J., Friedman, L., Posner, D., Kushida, C., Yesavage, J., Saletin, J., Goldstein-Piekarski, A. ELSEVIER SCIENCE INC. 2022: S370

  View details for Web of Science ID 000789022201277

• The Effect of Distinct Components of CBT-I on Slow Wave Power and Energy Ahmadi, M., Krause, A. J., O'Hora, K., Hernandez, B., Lazzeroni, L., Zeitzer, J., Friedman, L., Posner, D., Kushida, C., Yesavage, J. A., Saletin, J., Goldstein-Piekarski, A. ELSEVIER SCIENCE INC. 2022: S369-S370

  View details for Web of Science ID 000789022201276