Bio


I completed my undergraduate degree at the University of Toronto, and my PhD at the University of Cambridge. My work explores the neural mechanisms supporting episodic memory, and how these are affected by aging and Alzheimer's disease. I am currently leading the Stanford Aging and Memory Study, a large-scale longitudinal project examining individual differences in episodic memory in older adults. My research combines structural and functional MRI, PET imaging, and analysis of molecular and genetic risk factors for Alzheimer's disease.

Professional Education


  • Bachelor of Science, University of Toronto (2012)
  • Doctor of Philosophy, University of Cambridge (2016)

All Publications


  • Neural evidence for age-related differences in representational quality and strategic retrieval processes. Neurobiology of aging Trelle, A. N., Henson, R. N., Simons, J. S. 2019; 84: 50–60

    Abstract

    Mounting behavioral evidence suggests that declines in both representational quality and controlled retrieval processes contribute to episodic memory decline with age. The present study sought neural evidence for age-related change in these factors by measuring neural differentiation during encoding of paired associates and changes in regional blood oxygenation level-dependent activity and functional connectivity during retrieval conditions that placed low (intact pairs) and high (recombined pairs) demands on controlled retrieval processes. Pattern similarity analysis revealed age-related declines in the differentiation of stimulus representations at encoding, manifesting as both reduced pattern similarity between closely related events and increased pattern similarity between distinct events. During retrieval, both groups increased recruitment of areas within the core recollection network when endorsing studied pairs, including the hippocampus and angular gyrus. In contrast, only younger adults increased recruitment of, and hippocampal connectivity with, lateral prefrontal regions during correct rejections of recombined pairs. These results provide evidence for age-related changes in representational quality and in the neural mechanisms supporting memory retrieval under conditions of high, but not low, control demand.

    View details for DOI 10.1016/j.neurobiolaging.2019.07.012

    View details for PubMedID 31491595