All Publications

  • The Effect of Pressurized Carbon Dioxide Lavage on Osteochondral Allograft ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE Atzmon, R., Chang, W., Chan, C., Lin, K., Bryant, S. A., Seo, A., Cole, B. J., Abrams, G., Sherman, S. L. 2026; 14 (5)

    View details for DOI 10.1177/23259671261438104

    View details for Web of Science ID 001758198600001

  • The Effect of Pressurized Carbon Dioxide Lavage on Osteochondral Allograft. Orthopaedic journal of sports medicine Atzmon, R., Chang, W. T., Chan, C., Lin, K., Bryant, S. A., Seo, A., Cole, B. J., Abrams, G., Sherman, S. L. 2026; 14 (5): 23259671261438104

    Abstract

    Osteochondral allograft (OCA) transplantation is often utilized for treating osteochondral lesions of the knee due to limited cartilage regenerative capabilities. The use of liquid orthobiologic agents such as bone marrow aspirate concentrate has gained traction as a method to enhance OCA incorporation and healing. Pulse lavage and pressurized carbon dioxide (CO2) lavage are cleaning methods used during OCA preparation to remove native marrow elements, but their isolated and combined effects are not fully understood.This study aimed to assess the impact of incorporating pressurized CO2 lavage as an adjunct to pulse lavage during OCA preparation. It was hypothesized that adding pressurized CO2 lavage would enhance the OCA absorption capacity for liquid-based materials such as host-derived marrow constituents.Controlled laboratory study.OCA plugs were harvested from medial hemicondyles. The plugs were divided into 2 groups: one group underwent pulse lavage alone, and the other group underwent pulse lavage followed by pressurized CO2 lavage (sequential group). The plugs were weighed before and after each cleaning step, and a water-based dye solution was added by dripping. Next, the liquid content was determined by centrifugation and spectrophotometry. Results were analyzed statistically.A total of 34 OCA plugs with a 14 to 18 mm-diameter were harvested. After the cleaning phase, the sequential group showed a significant mean reduction in aqueous weight of 0.253 ± 0.110 g (107% ± 21%) (P < .0001) and a subsequent mean gain in aqueous weight of 0.231 ± 0.107 g (96% ± 19%) (P < .0001), after the cleaning and dye-dripping procedures. In contrast, the pulse lavage-only group exhibited a small mean weight gain of 0.028 ± 0.010 g (11% ± 4%) after the dye-dripping procedure.Adding pressurized CO2 lavage to pulse lavage improved OCA cleaning and increased uptake of an aqueous dye solution used as a surrogate for liquid orthobiologic agents in this ex vivo model.The study findings highlight the potential of incorporating pressurized CO2 lavage as an adjunct to pulse lavage during OCA preparation. These findings could enhance OCA preparation techniques by improving the removal of donor marrow elements and facilitating the subsequent ingress of fluid into the graft's cancellous portion.

    View details for DOI 10.1177/23259671261438104

    View details for PubMedID 42125513

    View details for PubMedCentralID PMC13158474

  • Innovations in Biomaterials in Orthopaedic Sports Medicine Surgery OPERATIVE TECHNIQUES IN SPORTS MEDICINE George, A., Seo, A., Sherman, S. L. 2025; 33 (4)

    View details for DOI 10.1016/j.otsm.2026.151212

    View details for Web of Science ID 001745710500001

https://orcid.org/0009-0002-2632-1905