Allen Yesin

All Publications

• Nuclear mechanobiology rules immune cells' functions: from differentiation to cell trafficking and pathogen killing. Nucleus (Austin, Tex.) Renkawitz, J., Yesin, A., Kroll, J., Cabral, A. T., D'Annunzio, S., Thiam, H. R. 2026; 17 (1): 2590843

  Abstract

  The immune system functions within tissue microenvironments of mechanical and geometrical constraints. Within these constraints, immune cells must rapidly move and execute effector functions to regulate innate and adaptive immunity. Here, we review the impact of nuclear mechanobiology on immune cell functionality. We define how non-genetic physical properties of the nucleus such as shape, stiffness and deformability are regulated and directly impact immune cell functions ranging from trafficking routes to pathogen killing. We highlight that studying immune cells allowed breakthroughs in understanding how the nucleus acts as a sensor for spatial constraints, as a break or enabler for cell migration, and as an extracellular trap to kill pathogens. Further, we discuss the unknowns of nuclear mechanobiology and consider the impact of chromatin, condensates, and nuclear membrane components. Together, this review provides an overarching framework of the cellular, physical, and immunological principles of nuclear mechanobiology in immune cells.

  View details for DOI 10.1080/19491034.2025.2590843

  View details for PubMedID 41495604

• In vitro generated neutrophils reveal high deformability is an emergent property Yesin, A., Flores, R., Thiam, H. CELL PRESS. 2026: 399a

  View details for Web of Science ID 001717743900206