Stanford Advisors

All Publications

  • Application of electrochromic thin films for electrophysiology Alfonso, F., McGuire, A., Li, T., Santoro, F., Cui, B. AMER CHEMICAL SOC. 2018
  • Interfacing Cells with Vertical Nanoscale Devices: Applications and Characterization. Annual review of analytical chemistry (Palo Alto, Calif.) McGuire, A. F., Santoro, F., Cui, B. 2018


    Measurements of the intracellular state of mammalian cells often require probes or molecules to breach the tightly regulated cell membrane. Mammalian cells have been shown to grow well on vertical nanoscale structures in vitro, going out of their way to reach and tightly wrap the structures. A great deal of research has taken advantage of this interaction to bring probes close to the interface or deliver molecules with increased efficiency or ease. In turn, techniques have been developed to characterize this interface. Here, we endeavor to survey this research with an emphasis on the interface as driven by cellular mechanisms. Expected final online publication date for the Annual Review of Analytical Chemistry Volume 11 is June 12, 2018. Please see for revised estimates.

    View details for DOI 10.1146/annurev-anchem-061417-125705

    View details for PubMedID 29570360

  • Biocompatible and totally disintegrable semiconducting polymer for ultrathin and ultralightweight transient electronics PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Lei, T., Guan, M., Liu, J., Lin, H., Pfattner, R., Shaw, L., McGuire, A. F., Huang, T., Shao, L., Cheng, K., Tok, J. B., Bao, Z. 2017; 114 (20): 5107-5112


    Increasing performance demands and shorter use lifetimes of consumer electronics have resulted in the rapid growth of electronic waste. Currently, consumer electronics are typically made with nondecomposable, nonbiocompatible, and sometimes even toxic materials, leading to serious ecological challenges worldwide. Here, we report an example of totally disintegrable and biocompatible semiconducting polymers for thin-film transistors. The polymer consists of reversible imine bonds and building blocks that can be easily decomposed under mild acidic conditions. In addition, an ultrathin (800-nm) biodegradable cellulose substrate with high chemical and thermal stability is developed. Coupled with iron electrodes, we have successfully fabricated fully disintegrable and biocompatible polymer transistors. Furthermore, disintegrable and biocompatible pseudo-complementary metal-oxide-semiconductor (CMOS) flexible circuits are demonstrated. These flexible circuits are ultrathin (<1 μm) and ultralightweight (∼2 g/m(2)) with low operating voltage (4 V), yielding potential applications of these disintegrable semiconducting polymers in low-cost, biocompatible, and ultralightweight transient electronics.

    View details for DOI 10.1073/pnas.1701478114

    View details for Web of Science ID 000401314700044

    View details for PubMedID 28461459

  • Accurate nanoelectrode recording of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease MICROSYSTEMS & NANOENGINEERING Lin, Z., McGuire, A. F., Burridge, P. W., Matsa, E., Lou, H., Wu, J. C., Cui, B. 2017; 3: 1–7
  • Imaging electric field dynamics with graphene optoelectronics NATURE COMMUNICATIONS Horng, J., Balch, H. B., McGuire, A. F., Tsai, H., Forrester, P. R., Crommie, M. F., Cui, B., Wang, F. 2016; 7


    The use of electric fields for signalling and control in liquids is widespread, spanning bioelectric activity in cells to electrical manipulation of microstructures in lab-on-a-chip devices. However, an appropriate tool to resolve the spatio-temporal distribution of electric fields over a large dynamic range has yet to be developed. Here we present a label-free method to image local electric fields in real time and under ambient conditions. Our technique combines the unique gate-variable optical transitions of graphene with a critically coupled planar waveguide platform that enables highly sensitive detection of local electric fields with a voltage sensitivity of a few microvolts, a spatial resolution of tens of micrometres and a frequency response over tens of kilohertz. Our imaging platform enables parallel detection of electric fields over a large field of view and can be tailored to broad applications spanning lab-on-a-chip device engineering to analysis of bioelectric phenomena.

    View details for DOI 10.1038/ncomms13704

    View details for Web of Science ID 000389853500001

    View details for PubMedID 27982125

    View details for PubMedCentralID PMC5172231

  • A skin-inspired organic digital mechanoreceptor SCIENCE Tee, B. C., Chortos, A., Berndt, A., Nguyen, A. K., Tom, A., McGuire, A., Lin, Z. C., Tien, K., Bae, W., Wang, H., Mei, P., Chou, H., Cui, B., Deisseroth, K., Ng, T. N., Bao, Z. 2015; 350 (6258): 313-?

    View details for DOI 10.1126/science.aaa9306

    View details for Web of Science ID 000362838700039

    View details for PubMedID 26472906

  • Impact of branching on the supramolecular assembly of thioethers on Au(111) JOURNAL OF CHEMICAL PHYSICS Murphy, C. J., Shi, X., Jewell, A. D., McGuire, A. F., Bellisario, D. O., Baber, A. E., Tierney, H. L., Lewis, E. A., Sholl, D. S., Sykes, E. C. 2015; 142 (10)


    Alkanethiolate monolayers are one of the most comprehensively studied self-assembled systems due to their ease of preparation, their ability to be functionalized, and the opportunity to control their thickness perpendicular to the surface. However, these systems suffer from degradation due to oxidation and defects caused by surface etching and adsorbate rotational boundaries. Thioethers offer a potential alternative to thiols that overcome some of these issues and allow dimensional control of self-assembly parallel to the surface. Thioethers have found uses in surface modification of nanoparticles, and chiral thioethers tethered to catalytically active surfaces have been shown to enable enantioselective hydrogenation. However, the effect of structural, chemical, and chiral modifications of the alkyl chains of thioethers on their self-assembly has remained largely unstudied. To elucidate how molecular structure, particularly alkyl branching and chirality, affects molecular self-assembly, we compare four related thioethers, including two pairs of structural isomers. The self-assembly of structural isomers N-butyl methyl sulfide and tert-butyl methyl sulfide was studied with high resolution scanning tunneling microscopy (STM); our results indicate that both molecules form highly ordered arrays despite the bulky tert-butyl group. We also investigated the effect of intrinsic chirality in the alkyl tails on the adsorption and self-assembly of butyl sec-butyl sulfide (BSBS) with STM and density functional theory and contrast our results to its structural isomer, dibutyl sulfide. Calculations provide the relative stability of the four stereoisomers of BSBS and STM imaging reveals two prominent monomer forms. Interestingly, the racemic mixture of BSBS is the only thioether we have examined to date that does not form highly ordered arrays; we postulate that this is due to weak enantiospecific intermolecular interactions that lead to the formation of energetically similar but structurally different assemblies. Furthermore, we studied all of the molecules in their monomeric molecular rotor form, and the surface-adsorbed chirality of the three asymmetric thioethers is distinguishable in STM images.

    View details for DOI 10.1063/1.4907270

    View details for Web of Science ID 000350978000016

    View details for PubMedID 25770504

  • Hydrogen Bonding and Chirality in Functionalized Thioether Self-Assembly JOURNAL OF PHYSICAL CHEMISTRY C McGuire, A. F., Jewell, A. D., Lawton, T. J., Murphy, C. J., Lewis, E. A., Sykes, E. C. 2012; 116 (28): 14992-14997

    View details for DOI 10.1021/jp3042507

    View details for Web of Science ID 000306503200031