All Publications

  • Effects of B.1.1.7 and B.1.351 on COVID-19 Dynamics: A Campus Reopening Study ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING Linka, K., Peirlinck, M., Schaefer, A., Tikenogullari, O., Goriely, A., Kuhl, E. 2021
  • Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease. Frontiers in physiology Schafer, A., Peirlinck, M., Linka, K., Kuhl, E., Alzheimer's Disease Neuroimaging Initiative (ADNI) 2021; 12: 702975


    Amyloid-beta and hyperphosphorylated tau protein are known drivers of neuropathology in Alzheimer's disease. Tau in particular spreads in the brains of patients following a spatiotemporal pattern that is highly sterotypical and correlated with subsequent neurodegeneration. Novel medical imaging techniques can now visualize the distribution of tau in the brain in vivo, allowing for new insights to the dynamics of this biomarker. Here we personalize a network diffusion model with global spreading and local production terms to longitudinal tau positron emission tomography data of 76 subjects from the Alzheimer's Disease Neuroimaging Initiative. We use Bayesian inference with a hierarchical prior structure to infer means and credible intervals for our model parameters on group and subject levels. Our results show that the group average protein production rate for amyloid positive subjects is significantly higher with 0.019±0.27/yr, than that for amyloid negative subjects with -0.143±0.21/yr (p = 0.0075). These results support the hypothesis that amyloid pathology drives tau pathology. The calibrated model could serve as a valuable clinical tool to identify optimal time points for follow-up scans and predict the timeline of disease progression.

    View details for DOI 10.3389/fphys.2021.702975

    View details for PubMedID 34335308

  • Towards Patient-Specific Computational Modelling of Articular Cartilage on the Basis of Advanced Multiparametric MRI Techniques SCIENTIFIC REPORTS Linka, K., Schaefer, A., Hillgaertner, M., Itskov, M., Knobe, M., Kuhl, C., Hitpass, L., Truhn, D., Thuering, J., Nebelung, S. 2019; 9: 7172


    Cartilage degeneration is associated with tissue softening and represents the hallmark change of osteoarthritis. Advanced quantitative Magnetic Resonance Imaging (qMRI) techniques allow the assessment of subtle tissue changes not only of structure and morphology but also of composition. Yet, the relation between qMRI parameters on the one hand and microstructure, composition and the resulting functional tissue properties on the other hand remain to be defined. To this end, a Finite-Element framework was developed based on an anisotropic constitutive model of cartilage informed by sample-specific multiparametric qMRI maps, obtained for eight osteochondral samples on a clinical 3.0 T MRI scanner. For reference, the same samples were subjected to confined compression tests to evaluate stiffness and compressibility. Moreover, the Mankin score as an indicator of histological tissue degeneration was determined. The constitutive model was optimized against the resulting stress responses and informed solely by the sample-specific qMRI parameter maps. Thereby, the biomechanical properties of individual samples could be captured with good-to-excellent accuracy (mean R2 [square of Pearson's correlation coefficient]: 0.966, range [min, max]: 0.904, 0.993; mean Ω [relative approximated error]: 33%, range [min, max]: 20%, 47%). Thus, advanced qMRI techniques may be complemented by the developed computational model of cartilage to comprehensively evaluate the functional dimension of non-invasively obtained imaging biomarkers. Thereby, cartilage degeneration can be perspectively evaluated in the context of imaging and biomechanics.

    View details for DOI 10.1038/s41598-019-43389-y

    View details for Web of Science ID 000467538500052

    View details for PubMedID 31073178