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  • Academic
    anakojic@stanford.edu
    University - Scholar Department: Cardiovascular Institute Operations Position: Postdoctoral Scholar

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All Publications

  • Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients caused by heterozygous mutations in the HCN4 gene. Stem cell research Yildirim, Z., Kojic, A., Yan, C. D., Wu, M. A., Vagelos, R., Wu, J. C. 2022; 65: 102951

    Abstract

    Dilated cardiomyopathy (DCM) is a progressive heart muscle disease that can culminate with heart failure and death. Mutations in several genes can cause DCM, including hyperpolarization-activated cyclic nucleotide-gated channel (HCN4), which has a critical function in the autonomic control of the heart rate. Here, we generated two human induced pluripotent stem cell (iPSC) lines generated from two DCM patients carrying variants in the HCN4 gene (c.2587G > T and c.2846G > A). Both lines display normal karyotype, typical morphology of pluripotent stem cells, and differentiate into all three germ layers in vitro. These lines are valuable resources for studying the pathological mechanisms of DCM.

    View details for DOI 10.1016/j.scr.2022.102951

    View details for PubMedID 36332467

  • Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying heterozygous FLNC mutations. Stem cell research Kojic, A., Kim, H., Guevara, J. V., Ravada, S., Sallam, K., Wu, J. C. 2022; 64: 102928

    Abstract

    Dilated cardiomyopathy (DCM) is a heterogeneous cardiac disorder characterized by left ventricular dilatation and dysfunction. Mutations in dozens of cardiac genes have been connected to the development of DCM including the filamin C gene (FLNC). We generated two induced pluripotent stem cell (iPSCs) lines from DCM patients carrying single missense heterozygote FLNC mutations (c.6689G > A and c.3745G > A). Both lines expressed high levels of pluripotency markers, differentiated into derivatives of the three germ layers and possessed normal karyotypes. The derived iPSC lines can serve as powerful tools to model DCM in vitro and as a platform for therapeutic development.

    View details for DOI 10.1016/j.scr.2022.102928

    View details for PubMedID 36194907

https://orcid.org/0000-0002-1829-9990