Contact

  • Academic
    University - Faculty other teaching Department: Medicine - Med/Pulmonary and Critical Care Medicine Position: Adjunct Clinical Professor

All Publications

  • Oxygen therapy for mitochondrial myopathy CHEST Winograd, C. H., Newman, A. B. 2002; 122 (4): 1496-1497

    View details for Web of Science ID 000178685200071

    View details for PubMedID 12377891

  • GLUCOREGULATION AND SIMULATED DIVING IN THE HARBOR SEAL PHOCA-VITULINA AMERICAN JOURNAL OF PHYSIOLOGY ROBIN, E. D., ENSINCK, J., HANCE, A. J., NEWMAN, A., LEWISTON, N., CORNELL, L., DAVIS, R. W., THEODORE, J. 1981; 241 (5): R293–R300

    Abstract

    Plasma glucose, glucagon, and insulin concentrations were measured in the harbor seal, Phoca vitulina, during a 6-min dive and a 30-min recovery period. Studies were performed in the fasting state and following intravenous glucose. During diving in the fasting state, values of plasma glucose, glucagon, and insulin are not significantly different from prediving values, presumably because of the loss of perfusion to the pancreas. In the postdiving period, plasma glucagon increases significantly. The increased glucagon levels reach a peak at 6 min into the postdiving period. By 4 min postdiving, plasma glucose values increase. The hyperglycemia appears to be at least partially related to hyperglucagonemia. Despite hyperglycemia, insulin levels do not change significantly. The net effect is to increase glucose availability, particularly for non-insulin-requiring tissues (brain). Preadministration of glucose eliminates the postdiving increase in glucagon. Plasma glucose and insulin concentrations also show no significant changes during the diving and postdiving periods. These results suggest that hormonally mediated glucose conservation serves to maintain brain glucose supplies and to restore peripheral carbohydrate stores during the postdiving period.

    View details for Web of Science ID A1981MS96200062

    View details for PubMedID 7030088

  • SHARK HEART-MITOCHONDRIA - EFFECTS OF EXTERNAL OSMOLALITY ON RESPIRATION SCIENCE LEWISTON, N., Newman, A., Robin, E., Holtzman, D. 1979; 206 (4414): 75-76

    Abstract

    Shark mitochondrial respiration was studied in media with osmolalities between 160 and 1500 milliosmoles. The respiratory control ratio, a marker for functional integrity of the isolated mitochondria, was maximal at 1000 millismoles and decreased during hypotonic or hypertonic exposure. Shark mitochondria function best at their native tonicity, a value that produces abnormal function in mammalian mitochondria.

    View details for Web of Science ID A1979HM63800032

    View details for PubMedID 482928

  • PECTUS EXCAVATUM AND CARDIOPULMONARY COMPLICATIONS WESTERN JOURNAL OF MEDICINE Robin, E. D., ABUABARA, F., Robin, E. D., Myers, C., Theodore, J., Hamner, P., Raffin, T., Hance, A., Newman, A., LYNNEDAVIES, P. 1979; 130 (6): 522-530

    View details for Web of Science ID A1979HG95600005

    View details for PubMedID 516691

    View details for PubMedCentralID PMC1238707

  • BIOENERGETIC PATTERN OF TURTLE BRAIN AND RESISTANCE TO PROFOUND LOSS OF MITOCHONDRIAL ATP GENERATION PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ROBIN, E. D., LEWISTON, N., NEWMAN, A., SIMON, L. M., THEODORE, J. 1979; 76 (8): 3922–26

    Abstract

    The adaptations in the freshwater turtle that permit survival despite prolonged loss of mitochondrial ATP generation were investigated by comparing the bioenergetics of turtle brain slices with rat brain slices. Aerobic turtle brain shows no significant difference in basal levels of total ATP generation compared to rat brain; levels in turtle brain and rat brain were 18.4 +/- 2.8 (SD) and 19.4 +/- 2.2 mumol (100 mg of tissue)-1 hr-1, respectively. However, in turtle brain, a significantly greater fraction of ATP is derived from glycolysis both under aerobic and anaerobic conditions [aerobic turtle (24%) and rat (13%), P less than 0.02; anaerobic, turtle (28%) and rat (18%), P less than 0.05]. The increased glycolytic capacity is related to high levels of rate-limiting glycolytic enzymes, such as pyruvate kinase (EC 2.7.1.40). Turtle brain operates close to glycolytic capacity even under aerobic conditions, and no Pasteur effect can be demonstrated. Quantitatively, anaerobic glycolysis accounts for a maximum of 28% of basal aerobic ATP generation, suggesting that prolonged diving is also accompanied by a reduction in brain energy requirements. The adaptation subserving short-term (natural) diving is an increase in brain glycolytic capacity. The adaptation subserving prolonged diving (days to weeks) may be a reduction in the energy requirements of brain (and other cells).

    View details for DOI 10.1073/pnas.76.8.3922

    View details for Web of Science ID A1979HJ25800076

    View details for PubMedID 291050

    View details for PubMedCentralID PMC383948

  • GLUCOREGULATION IN AQUATIC MAMMALS AS A MODEL FOR THE DEFENSE OF BRAIN GLUCOSE REQUIREMENTS Robin, E. D., ENSINCK, J., Newman, A., LEWISTON, N., Davis, R., Cornell, L. SLACK INC. 1979: A518–A518

    View details for Web of Science ID A1979GR63102233

  • TURTLE BRAIN BIOENERGETICS - MODEL FOR PROFOUND AND PROLONGED HYPOXIA LEWISTON, N. J., Robin, E. D., Newman, A., Simon, L. M., Theodore, J. SLACK INC. 1979: A400–A400

    View details for Web of Science ID A1979GR63101536

  • TURTLE BRAIN BIOENERGETICS - MODEL FOR PROFOUND AND PROLONGED HYPOXIA LEWISTON, N. J., Robin, E. D., Newman, A., Simon, L. M., Theodore, J. SLACK INC. 1979: A90–A90

    View details for Web of Science ID A1979GC72700531