Antonio Amodeo

All Publications

• Heart Transplantation and Ventricular Assist Device in Duchenne Muscular Dystrophy: A New Era. Pediatric transplantation Rosenthal, D. N., Amodeo, A., Butterfield, R. J., Butts, R., Chrzanowski, S., Cripe, L., Day, J., Davies, R., Duong, T., Evers, P., Gambetta, K., Harris, R., Hayes, E., Kaufman, B., Lorts, A., Mack, G., Mackenzie, S. J., Mammen, P., Markham, L., McAlister, J., McDonald, C., Nakano, S. J., Nandi, D., Navaratnam, M., Nelson, S., Parent, J. J., Piccoli, C., Richmond, M., Rocha, C., Sawnani, H., Schrader, R., Shell, R., Shih, R., Shugh, S., Smart, T., Soslow, J., Spinner, J., Taivassalo, T., Tunugtla, H., VanderPluym, C., Veerapandiyan, A., Villa, C., Wittlieb-Weber, C., Zafarullah, M., Hollander, S. 2026; 30 (1): e70253

  Abstract

  Duchenne muscular dystrophy (DMD) is an X-linked genetic neuromuscular disorder that is caused by a mutation in the dystrophin gene. The disease is characterized by progressive weakness of skeletal muscle, resulting in loss of ambulation and eventually respiratory insufficiency. Cardiac muscle is also involved, and cardiomyopathy is a prominent feature of DMD. The care of patients with DMD has changed in important ways over the past 15 years, with the use of chronic steroid therapy combined with noninvasive respiratory support such as continuous positive airway pressure for home use. More recently, therapies targeting specific genetic mutations in DMD have been approved, using gene-skipping oligonucleotides, and many other novel therapies are being evaluated in clinical trials, including mini-dystrophin genes delivered by viral vectors. In view of this new era in care and outcomes, it is appropriate to review the role of advanced cardiac therapies such as ventricular assist devices and heart transplantation in the care of this population. In September 2024, a group of healthcare professionals with expertise in DMD and heart failure convened to review this topic; the consensus opinion of this group (DMD Cardiac Care Consortium) is presented in this manuscript.

  View details for DOI 10.1111/petr.70253

  View details for PubMedID 41424087

• ISHLT consensus statement for the selection and management of pediatric and congenital heart disease patients on ventricular assist devices Endorsed by the American Heart Association. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Lorts, A., Conway, J., Schweiger, M., Adachi, I., Amdani, S., Auerbach, S. R., Barr, C., Bleiweis, M. S., Blume, E. D., Burstein, D. S., Cedars, A., Chen, S., Cousino-Hood, M. K., Daly, K. P., Danziger-Isakov, L. A., Dubyk, N., Eastaugh, L., Friedland-Little, J., Gajarski, R., Hasan, A., Hawkins, B., Jeewa, A., Kindel, S. J., Kogaki, S., Lantz, J., Law, S. P., Maeda, K., Mathew, J., May, L. J., Miera, O., Murray, J., Niebler, R. A., O'Connor, M. J., Ozbaran, M., Peng, D. M., Philip, J., Reardon, L. C., Rosenthal, D. N., Rossano, J., Salazar, L., Schumacher, K. R., Simpson, K. E., Stiller, B., Sutcliffe, D. L., Tunuguntla, H., VanderPluym, C., Villa, C., Wearden, P. D., Zafar, F., Zimpfer, D., Zinn, M. D., Morales, I. R., Cowger, J., Buchholz, H., Amodeo, A. 2021

  View details for DOI 10.1016/j.healun.2021.04.015

  View details for PubMedID 34193359

• Part VII: Behavioral economics-A framework for donor organ decision-making in pediatric heart transplantation. Pediatric transplantation Butler, A. n., Chapman, G. n., Johnson, J. N., Amodeo, A. n., Böhmer, J. n., Camino, M. n., Davies, R. R., Dipchand, A. I., Godown, J. n., Miera, O. n., Pérez-Blanco, A. n., Rosenthal, D. N., Zangwill, S. n., Kirk, R. n. 2020: e13655

  Abstract

  The high discard rate of pediatric donor hearts presents a major challenge for children awaiting heart transplantation. Recent literature identifies several factors that contribute to the disparities in pediatric donor heart usage, including regulatory oversight, the absence of guidelines on pediatric donor heart acceptance, and variation among transplant programs. However, a likely additional contributor to this issue are the behavioral factors influencing transplant team decisions in donor offer scenarios, a topic that has not yet been studied in detail. Behavioral economics and decision psychology provide an excellent foundation for investigating decision-making in the pediatric transplant setting, offering key insights into the behavior of transplant professionals. We conducted a systematic review of published literature in pediatric heart transplant related to behavioral economics and the psychology of decision-making. In this review, we draw on paradigms from these two domains in order to examine how existing aspects of the transplant environment, including regulatory oversight, programmatic variation, and allocation systems, may precipitate potential biases surrounding donor offer decisions. Recognizing how human decision behavior influences donor acceptance is a first step toward improving utilization of potentially viable pediatric donor hearts.

  View details for DOI 10.1111/petr.13655

  View details for PubMedID 31985140

• ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Kirk, R. n., Dipchand, A. I., Davies, R. R., Miera, O. n., Chapman, G. n., Conway, J. n., Denfield, S. n., Gossett, J. G., Johnson, J. n., McCulloch, M. n., Schweiger, M. n., Zimpfer, D. n., Ablonczy, L. n., Adachi, I. n., Albert, D. n., Alexander, P. n., Amdani, S. n., Amodeo, A. n., Azeka, E. n., Ballweg, J. n., Beasley, G. n., Böhmer, J. n., Butler, A. n., Camino, M. n., Castro, J. n., Chen, S. n., Chrisant, M. n., Christen, U. n., Danziger-Isakov, L. n., Das, B. n., Everitt, M. n., Feingold, B. n., Fenton, M. n., Garcia-Guereta, L. n., Godown, J. n., Gupta, D. n., Irving, C. n., Joong, A. n., Kemna, M. n., Khulbey, S. K., Kindel, S. n., Knecht, K. n., Lal, A. K., Lin, K. n., Lord, K. n., Möller, T. n., Nandi, D. n., Niesse, O. n., Peng, D. M., Pérez-Blanco, A. n., Punnoose, A. n., Reinhardt, Z. n., Rosenthal, D. n., Scales, A. n., Scheel, J. n., Shih, R. n., Smith, J. n., Smits, J. n., Thul, J. n., Weintraub, R. n., Zangwill, S. n., Zuckerman, W. A. 2020

  Abstract

  The number of potential pediatric heart transplant recipients continues to exceed the number of donors, and consequently the waitlist mortality remains significant. Despite this, around 40% of all donated organs are not used and are discarded. This document (62 authors from 53 institutions in 17 countries) evaluates factors responsible for discarding donor hearts and makes recommendations regarding donor heart acceptance. The aim of this statement is to ensure that no usable donor heart is discarded, waitlist mortality is reduced, and post-transplant survival is not adversely impacted.

  View details for DOI 10.1016/j.healun.2020.01.1345

  View details for PubMedID 32088108

• First human implantation of a miniaturized axial flow ventricular assist device in a child with end-stage heart failure. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Amodeo, A., Filippelli, S., Perri, G., Iacobelli, R., Adorisio, R., Iodice, F., Rizza, A., Massicotte, M. P., Baldwin, J. T., Almond, C. S. 2019

  View details for DOI 10.1016/j.healun.2019.09.003

  View details for PubMedID 31761510