Arvin Eslami

All Publications

• The frequency of AmpC overproduction, OprD downregulation and OprM efflux pump expression in Pseudomonas aeruginosa: A comprehensive meta-analysis. Journal of global antimicrobial resistance Alimoghadam, S., Eslami, A., Alimoghadam, R., Bahrami Mianrood, I., Azizmohammad Looha, M., Khodadadi, S., Shokouhi, S., Alavi Darazam, I. 2024; 39: 159-169

  Abstract

  Pseudomonas aeruginosa is a major opportunistic pathogen responsible for a wide range of infections. The emergence of antibiotic resistance in this pathogen poses a significant public health challenge. This study aims to conduct a comprehensive meta-analysis of studies conducted in Iran to determine the frequency of key antibiotic resistance mechanisms in Pseudomonas aeruginosa and their association with multidrug-resistant and extensively drug-resistant strains or pandrug-resistant strains.Systematic database searches encompassing literature up to June 2023 were undertaken. The selected studies centered on OprD downregulation, efflux pump (mexAB-OprM, mexXY-OprM) expression, and AmpC overproduction. Extracted data were synthesised in a meta-analysis for pooled frequency determination of each resistance mechanism.In total, 24 studies were included. OprD downregulation exhibited a pooled frequency of 61%. Efflux pump component frequency ranged from 48% to 77.5%. AmpC overproduction was identified in 29.1% of isolates. Polymyxin B and colistin demonstrated lower antibiotic resistance rates, with pooled frequency of 1% and 1.6%, respectively. Conversely, resistance to other antibiotics ranged widely, with pooled frequency spanning 38.4% to 98.2%.This study underscores the concerning frequency of diverse antibiotic resistance mechanisms in Pseudomonas aeruginosa strains from Iran. Concurrent OprD downregulation, mexAB, mexXY, OprM expression, and AmpC overproduction highlight the urgent need for stringent infection control and prudent antibiotic usage to curb the dissemination of these resistant strains.CRD42022379311.

  View details for DOI 10.1016/j.jgar.2024.08.014

  View details for PubMedID 39303871

• Comprehensive insights into tuberculosis-associated hemophagocytic lymphohistiocytosis: a systematic review. BMC infectious diseases Eslami, A., Alimoghadam, S., Khodadadi, S., Allahverdi, H., Alimoghadam, R., Kasaeian, A., Mansouri, D., Alimoghaddam, K., Alavi Darazam, I. 2024; 24 (1): 1341

  Abstract

  Tuberculosis-associated hemophagocytic lymphohistiocytosis (TB-HLH) presents significant challenges in diagnosis and treatment due to its complex interplay between TB and HLH. This systematic review aims to provide comprehensive insights into the epidemiology, clinical characteristics, and treatment outcomes of TB-HLH patients.We performed a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Scopus, Web of Science, and Embase up to May 16, 2023, without language restrictions. We included case reports and cases series on patients with both TB and HLH with documented treatment outcomes. Data were analyzed using descriptive statistics, chi-square or Fisher's exact tests, t-tests, and mortality rates. Significant variables (p < 0.05) from univariate analysis and clinically relevant factors were used in binary logistic regression to determine odds ratios, 95% confidence intervals, and p-values.A total of 185 articles involving 213 patients were included. The overall mortality rate was 39%. Age ≥ 44 years and comorbidities were identified as independent risk factors for increased mortality (p = 0.005). Anti-tuberculosis treatment (ATT) combined with HLH-specific therapies, was associated with reduced mortality compared to ATT alone (p < 0.05), especially IVIG (p = 0.04).Integrating ATT with HLH-specific therapies significantly enhances survival in TB-HLH patients. Additionally, IVIG plays a key role in improving outcomes. Age ≥ 44 years and comorbidities are critical risk factors for increased mortality. Early and high suspicion of TB-HLH is essential, especially in high TB burden regions or recent travel contexts. Future research should focus on prospective multicenter studies to validate our findings and develop standardized treatment strategies on TB-HLH.CRD42022364180.

  View details for DOI 10.1186/s12879-024-10220-7

  View details for PubMedID 39581974

  View details for PubMedCentralID PMC11587777

• Mpox vaccination and treatment: a systematic review. Journal of chemotherapy (Florence, Italy) Eslami, A., Alimoghadam, S., Khoshravesh, S., Shirani, M., Alimoghadam, R., Alavi Darazam, I. 2024; 36 (2): 85-109

  Abstract

  The Human monkeypox virus (mpox) belongs to the Poxviridae family, characterized by double-stranded DNA. A 2022 outbreak, notably prevalent among men who have sex with men, was confirmed by the World Health Organization. To understand shifting prevalence patterns and clinical manifestations, we conducted a systematic review of recent animal and human studies. We comprehensively searched PubMed, Scopus, Web of Science, Cochrane Library, and Clinicaltrials.gov, reviewing 69 relevant articles from 4,342 screened records. Our analysis highlights Modified Vaccinia Ankara - Bavarian Nordic (MVA-BN)'s potential, though efficacy concerns exist. Tecovirimat emerged as a prominent antiviral in the recent outbreak. However, limited evidence underscores the imperative for further clinical trials in understanding and managing monkeypox.

  View details for DOI 10.1080/1120009X.2023.2289270

  View details for PubMedID 38069596

• Anatomy and pattern of tibial periosteal circulation: implications for tibial plating : a cadaveric study. Bone & joint research Kalhor, M., Elahifar, O., Eslami, A., Gharehdaghi, J. 2025; 14 (9): 769-776

  Abstract

  The significance of periosteal vessels in the healing of tibial shaft fractures is well-established. However, the gross anatomical patterns and differential distribution of these vessels on the medial versus lateral surface of the tibial shaft have not been thoroughly described. This study aimed to illustrate the comparative anatomy of periosteal circulation on the medial versus lateral surface of the tibial shaft, where tibial plates are commonly applied.Ten adult fresh cadavers underwent aortic injection with coloured silicone to investigate the vascular system of the lower limbs, including the tibial extraosseous circulation. Following material fixation, the medial and lateral tibial surfaces were dissected extraperiosteally from the knee to the ankle joint to visualize the gross anatomy of periosteal vessels running along the medial and lateral surfaces of the tibial shaft.In all specimens, periosteal vessels on the lateral tibial consisted of six to eight main trunks in 17 out of 20 specimens. These vessels were evenly distributed, horizontally oriented, and exhibited variable side branching. Most of these vessels crossed the anterior tibial crest, terminating on the medial side. The extensor muscles on the lateral tibial surface made negligible contributions to the periosteal circulation. The medial tibial surface received its periosteal blood supply partly from the terminal branches of the traversing vessels from the lateral surface and partly from branches of the posterior tibial artery. These vessels were shorter, smaller, sparsely scattered, randomly distributed, and exhibited greater variability in number and size compared to their lateral counterparts.Periosteal circulation to the anterior two-thirds of the tibial shaft is mainly delivered through the lateral tibial surface. When periosteal circulation is a concern, lateral plating may be more disruptive compared to medial plating.

  View details for DOI 10.1302/2046-3758.149.BJR-2024-0547.R2

  View details for PubMedID 40897377

  View details for PubMedCentralID PMC12404821

• Systematic review of radiocarpal dislocations: epidemiology, treatment modalities, and outcomes. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie Eslami, A., Torkaman, A., Alimoghadam, S., Pisoudeh, K., Ebrahimzadeh Babaki, A., Ghaeini, M., Torkaman, P., Elahifar, O., Dehghani Nazhvani, H. 2025; 35 (1): 132

  Abstract

  Radiocarpal dislocation (RCD) is a rare but severe injury, often resulting from high-energy trauma such as motor vehicle accidents and falls. This study aims to synthesize existing case reports and series to provide insights into the epidemiology, associated injuries, and management strategies for RCD.A systematic search of PubMed, Scopus, and Web of Science was conducted, including English-language case reports and series up to August 5, 2023. Data extraction followed PRISMA guidelines, with bias assessment using Joanna Briggs Institute criteria. Descriptive statistics and t tests were applied to analyze demographics, treatments, and outcomes.Among 343 articles, 57 met inclusion criteria, covering 303 patients. The mean age was 36.52 years, with males comprising 78.9%. Dorsal dislocations were the most common type. Fractures, particularly of the radial styloid, were present in most cases. Common soft tissue injuries included median nerve compression, TFCC/DRUJ injuries, and scapholunate ligament tears. Ligament repair, performed in 24.7% of cases, improved flexion-extension outcomes (p = 0.048) but showed no significant effects on ulnar or radial deviation. Spanning plates demonstrated acceptable outcomes in one study.RCDs are complex injuries requiring comprehensive diagnostic assessment and tailored treatment strategies, particularly addressing associated fractures and soft tissue damage. While ligament repair may enhance flexion-extension, its role in overall joint stability remains uncertain. Further prospective, multicenter studies are needed to better evaluate treatment approaches, including the effectiveness of ligament repair, and to refine management protocols for improved long-term patient outcomes.

  View details for DOI 10.1007/s00590-025-04252-1

  View details for PubMedID 40137999

  View details for PubMedCentralID 8982567

• Pathomorphological features of the proximal femur in crowe IV hips and their implication on stem selection during total hip arthroplasty. BMC musculoskeletal disorders Gharanizadeh, K., Mohammadyahya, E., Bahaeddini, M. R., Amiri, S., Gravand, S. N., Pezeshki, S., Aminian, A., Eslami, A., Tayyebi, H., Abolghasemian, M. 2025; 26 (1): 108

  Abstract

  The best stem type and location for femoral shortening in high-riding developmental dysplasia of the hip (DDH) in not clear. We evaluated the morphology of the proximal femur on EOS™ images, focusing on the anatomical landmarks and measurements relevant to the stem selection in high-riding DDH. Our goal is to identify and define the differences in the anatomy of the proximal femur between patients with Crowe type IV DDH and normal individuals, in order to determine the appropriate neck cut location in these patients to increase the chances of successfully using a wedge femoral stem.EOS™ images of 40 hips with Crowe type-IV DDH and 40 normal hips were included. The distances between the tip of the greater trochanter and vastus ridge (GT-VR), vastus ridge and proximal border of lesser trochanter (VR-LT), greater- and lesser trochanters (GT-LT), base width of the LT, and the proportion of these distances to the femoral length were evaluated. Canal Flare Index (CFI) was also measured, at two different levels.The mean GT-LT index was not different between the two groups (p = 0.46). The GT-VR index was smaller in the case group (p < 0.001), while the VR-LT index was greater (p < 0.001). The LT base width index was larger in the case group (P < 0.001). CFI was smaller at the LT level in dysplastic hips (P < 0.001), but the values were similar with a cut 1.5 cm above the LT (P = 0.67).In Crowe IV hips, the GT height is shorter and the LT is located far more distally along the femoral metaphysis, resulting in a narrower canal width at the upper border of the lesser trochanter. Also, the CFI at the LT level is smaller, and to fit a wedge stem, the neck cut should be made at a higher level.

  View details for DOI 10.1186/s12891-024-08201-7

  View details for PubMedID 39901094

  View details for PubMedCentralID PMC11789299

• Traumatic pelvic ring fracture during pregnancy: a systematic review. EFORT open reviews Eslami, A., Chehrassan, M., Alimoghadam, S., Pisoudeh, K., Kasaeian, A., Elahifar, O. 2024; 9 (7): 700-711

  Abstract

  This systematic review aims to investigate the management and outcomes of pelvic ring fractures (PRFs) during pregnancy, emphasizing maternal and fetal mortality rates, mechanisms of injury, and treatment modalities.Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive search of databases from 2000 to 2023, identifying 33 relevant studies. Data extraction included demographics, fracture types, treatment methods, and outcomes. Risk of bias was assessed using the JBI criteria.Maternal mortality stood at 9.1%, with fetal mortality at 42.4%. Maternal factors impacting mortality included head trauma and hemodynamic instability. Fetal mortality correlated with mechanisms like motor vehicle accidents and maternal vital signs. Surgical and conservative treatments were applied, with a majority of pelvic surgeries performed before delivery. External fixators proved effective in fracture stabilization.Pelvic ring fractures during pregnancy present significant risks to maternal and fetal health. Early stabilization and vigilant monitoring of maternal vital signs are crucial. Vaginal bleeding/discharge serves as a critical fetal risk indicator. The choice between surgical and conservative treatment minimally influenced outcomes. Multidisciplinary collaboration and tailored interventions are essential in managing these complex cases.

  View details for DOI 10.1530/EOR-23-0164

  View details for PubMedID 38949162

  View details for PubMedCentralID PMC11297399

• Unusual presentation of talonavicular joint pigmented villonodular synovitis: a case report. Journal of medical case reports Elahifar, O., Torkaman, A., Ghaeini, M., Eslami, A. 2024; 18 (1): 60

  Abstract

  Pigmented villonodular synovitis is a rare yet locally invasive disorder impacting synovial tissues. This case report delineates the atypical manifestation of pigmented villonodular synovitis in the talonavicular joint, detailing its diagnostic complexity and successful management.A 56-year-old Iranian patient with a 4-year history of chronic ankle pain, initially diagnosed with degenerative joint disease post-trauma based on imaging, underwent talonavicular fusion surgery. An unexpected pigmented villonodular synovitis mass was encountered during the procedure. Subsequent interventions encompassed tumor resection, talonavicular joint fusion, and allograft bone grafting. Despite the initial intervention, persistent pain and nonunion necessitated a secondary procedure, involving joint surface curettage and autograft bone grafting. At the 12-month follow-up, the patient remained pain-free without tumor recurrence.This case report highlights the significance of considering pigmented villonodular synovitis as a crucial differential diagnosis in chronic ankle pain, even when there is evidence of degenerative joint disease and a history of trauma. Magnetic resonance imaging serves a crucial role in accurate diagnosis. Treatment necessitates precise tumor removal, appropriate bone grafting techniques and secure fixation.IV.

  View details for DOI 10.1186/s13256-024-04385-7

  View details for PubMedID 38369524

  View details for PubMedCentralID PMC10875799

• Aspirin is as effective as low molecular weight heparins in preventing symptomatic venous thromboembolism following arthroscopic anterior cruciate ligament reconstruction. BMC musculoskeletal disorders Yazdi, H., Eslami, A., Torkaman, A., Elahifar, O., Kasaeian, A., Alimoghadam, S., Alimoghadam, R., Abolghasemian, M. 2024; 25 (1): 154

  Abstract

  The optimal agent for thromboprophylaxis following arthroscopic anterior cruciate ligament reconstruction (ACLR) remains unclear, particularly in patients with a low baseline risk for venous thromboembolism (VTE). This retrospective cohort study aims to compare the effectiveness and safety of aspirin versus low molecular weight heparins (LMWHs) in this specific patient population.We analyzed data from patients who underwent ACLR between March 2016 and March 2021, focusing on those with a low risk for VTE. High-risk individuals, identified by factors such as cardiac disease, pulmonary disease, diabetes mellitus, previous VTE, inflammatory bowel disease, active cancer, and a BMI > 40, were excluded (n = 33). Our approach included a thorough review of medical charts, surgical reports, and pre-operative assessments, complemented by telephone follow-up conducted over a 3-month period by a single investigator. We assessed the incidence of symptomatic VTE, including deep vein thrombosis and pulmonary thromboembolism, as the primary outcome. The secondary outcomes included to complications related to the surgery and thromboprophylaxis. Statistical analysis included descriptive statistics, univariate logistic regression models, and calculations of incidence rates.In our study, 761 patients (761 knees) were included, with 458 (60.18%) receiving aspirin and 303 (39.82%) receiving LMWH. The two groups showed no significant differences in demographic factors except for age. The incidence of VTE was reported at 1.31% (10 individuals). Specifically, five patients in the aspirin group (1.09%) and five patients in the LMWH group (1.65%) developed a symptomatic VTE event (p = 0.53). Additionally, the two groups did not significantly differ in terms of other complications, such as hemarthrosis or surgical site infection (p > 0.05). Logistic regression analysis revealed no statistically significant difference in VTE risk between the two groups.This study, focusing on isolated ACLR in patients with a low baseline risk for venous thromboembolism, demonstrated that aspirin is equally effective as low molecular weight heparins for VTE prophylaxis following this surgery.III.

  View details for DOI 10.1186/s12891-024-07282-8

  View details for PubMedID 38373950

  View details for PubMedCentralID PMC10875785

• Reliability and Validity of the Persian Version of the Body Image Disturbance Questionnaire-Scoliosis in Patients with Adolescent Idiopathic Scoliosis Who Did Not Have Surgical Indication. The archives of bone and joint surgery Shakeri, M., Mahdavi, S. M., Nikouei, F., Ameri, E., Eslami, A., Habibollahzadeh, A., Ghandhari, H. 2023; 11 (2): 130-135

  Abstract

  Adolescent Idiopathic Scoliosis (AIS) is the most common spinal deformity disorder associated with bad posture and reduced quality of life. The Body Image Disturbance Questionnaire-Scoliosis (BIDQ-S) is a self-report instrument that assesses the concerns of scoliotic patients. This study aimed to translate and evaluate the reproducibility and internal consistency of the BIDQ-S in the Persian-speaking population worldwide suffering from AIS.The BIDQ-S was translated into Persian by two native-speaking Iranian translators and back-translated into English by two native-English translators. The resulting back-translated English BIDQ-S was then sent to the authors of the English BIDQ-S questionnaire for validation. After translation, it was provided for 41 AIS patients from those who referred to the outpatient clinics of Shafa Yahyaian Hospital from January 2020 to January 2021. Patients were asked to complete the Persian BIDQ-S and Persian Scoliosis Research Society-22 (SRS-22) inventories. Internal consistency and reproducibility were assessed using Cronbach's alpha and interclass correlation coefficients (ICC), respectively. The validity of the questionnaire was evaluated by comparing the scores obtained on the Persian BIDQ-S (P-BIDQ-S) inventory with those obtained on the SRS-22 subscales.The consistency and reliability of the P- BIDQ-S inventory were confirmed by Cronbach's alpha of 0.856 and interclass correlation coefficients of 0.882. The P-BIDQ-S scores directly correlated with the level of education of patients (r=0.21, P=0.041). The correlation coefficient between the P-BIDQ-S inventory and the SRS-22 questionnaire was -0.56 (P=0.001). A significant correlation was also observed between the P-BIDQ-S items and all of the SRS-22 subscales (P<0.05).The P-BIDQ-S inventory maintains adequate reliability, internal consistency, and reproducibility for the evaluation of Persian-speaking AIS patients.

  View details for DOI 10.22038/ABJS.2022.66298.3170

  View details for PubMedID 37168827

  View details for PubMedCentralID PMC10165678

• Fixation method can affect posterior tibial slope in opening-wedge high tibial osteotomy: a retrospective study. Journal of orthopaedic surgery and research Yazdi, H. R., Torkaman, A., Ebrahimzadeh Babaki, A., Soleimani, M., Eslami, A. 2023; 18 (1): 780

  Abstract

  Posterior tibial slope (PTS) alterations following open-wedge high tibial osteotomy (OWHTO) can cause instability and excessive tibial translation in the sagittal plane. These changes can be influenced by the type of fixation. This study aims to compare PTS changes between patients undergoing OWHTO with Puddu plate or TomoFix plate fixation.In this retrospective cohort study, we included 104 knees from 85 patients undergoing OWHTO, with a mean age of 41.98 ± 9.95 years; 51.8% of the participants were male. Seventy-two knees were fixed with Puddu plates, while 32 knees were fixed with TomoFix plates. PTS changes, demographic factors, Cincinnati Knee Rating Score (CKRS), Tegner-Lysholm score (TLS), length of stay (LOS), and complications were evaluated. PTS changes were measured preoperatively, immediately postoperatively, and at the 6-month follow-up.Demographic factors were similar between the Puddu plate and TomoFix groups. There were no significant differences in preoperative, postoperative, or follow-up PTS measurements between the two groups. PTS changes were not significant in the TomoFix group postoperatively or at follow-up. However, the Puddu plate group showed a significant increase in PTS both postoperatively (P = 0.027) and at follow-up (P = 0.014). CKRS, TLS, LOS, and complications did not significantly differ between the groups.While overall PTS changes did not significantly differ between the Puddu Plate and TomoFix Plate groups, analyzing changes within each group revealed distinct results. TomoFix fixation exhibited nonsignificant PTS changes, while Puddu plate fixation resulted in a significant increase in PTS after surgery and at the 6-month follow-up. Our findings suggest that the choice of fixation may influence PTS changes after OWHTO.Level III.

  View details for DOI 10.1186/s13018-023-04281-8

  View details for PubMedID 37848897

  View details for PubMedCentralID PMC10583342

• Congenital lumbosacral junction kyphosis in an adult patient: A case report. Clinical case reports Eslami, A., Chehrassan, M., Alimoghadam, S., Shakeri, M. 2023; 11 (10): e8094

  Abstract

  Rare lumbosacral junction kyphosis due to S1-S2 hemivertebra in a 40-year-old woman was managed surgically, improving neurological disturbances, and low back pain. Early intervention is vital for congenital anomalies.

  View details for DOI 10.1002/ccr3.8094

  View details for PubMedID 37881197

  View details for PubMedCentralID PMC10593970

• Trans-Table Intraoperative Fluoroscopic Technique for Obtaining a True Lateral View of the Proximal Femur in the Lateral Decubitus Position. The archives of bone and joint surgery Pisoudeh, K., Elahifar, O., Alimoghadam, S., Eslami, A. 2023; 11 (8): 531-534

  Abstract

  The management of proximal femoral fractures, especially comminuted subtrochanteric ones, poses a surgical challenge. It is relatively easier to perform the open reduction of these fractures in the lateral position on a standard radiolucent table, but obtaining an accurate lateral view of the femoral head and neck remains difficult. This study presents a method that overcomes the limitations of fluoroscopy in the lateral decubitus position and improves the accuracy of obtaining a true lateral view. The technique involves positioning the patient in the lateral decubitus position with the unaffected hip flexed at a 45° angle. Additionally, the C-arm is tilted 30-35° cephalad, eliminating the need for position changes or leg manipulation. This method reduces the risk of losing reduction, particularly in cases involving obese patients or complex fractures. By simplifying proximal femur fixation in the lateral decubitus position, this technique can potentially improve patient outcomes.

  View details for DOI 10.22038/ABJS.2023.73085.3386

  View details for PubMedID 37674698

  View details for PubMedCentralID PMC10479822

• External Fixator as a Viable Treatment Option for Combined Pelvic Ring and Sacrum Fracture in a Pregnant Patient: A Case Report. The archives of bone and joint surgery Pisoudeh, K., Alimoghadam, S., Elahifar, O., Eslami, A. 2023; 11 (7): 476-480

  Abstract

  We report a case of a 32-year-old pregnant woman who suffered a combined type pelvic fracture and medial malleolus fracture due to a car accident at 24 weeks and 2 days of gestation. She underwent external fixation of the pelvic ring and percutaneous screw fixation of the ankle fracture. She recovered well and delivered a healthy baby by cesarean section at 37 weeks and 1-day gestation. External fixation can be a definitive treatment option for some pelvic fractures with anterior instability in pregnant patients, as it reduces the risk of fetal harm.

  View details for DOI 10.22038/ABJS.2023.71908.3355

  View details for PubMedID 37538134

  View details for PubMedCentralID PMC10394743

• Effect of aspirin in preventing deep vein thrombosis (DVT) after lumbar canal spinal stenosis surgeries: a double-blind parallel randomized clinical trial CURRENT ORTHOPAEDIC PRACTICE Nikouei, F., Chehrassan, M., Shakeri, M., Mahdavi, S., Amerk, E., Eslami, A., Habibollahzadeh, A., Ghandhari, H. 2022; 33 (6): 543-547

  View details for DOI 10.1097/BCO.0000000000001169

  View details for Web of Science ID 000877219300008