Education & Certifications

  • B.S., University of California, Berkeley, Chemical Engineering (2025)

Contact

  • Academic
    bdaymo@stanford.edu
    University - Student Department: Chemical Engineering Position: Graduate

Additional Info

All Publications

  • Enzymatic Synthesis of a Polyketide/Nonribosomal Peptide Hybrid Antibiotic, Salivabactin. Biochemistry Gu, D., Zhai, R., Daymo, B., Xie, Y., Luo, C., Zhang, W. 2024; 63 (24): 3213-3219

    Abstract

    Salivabactin is a newly identified polyketide/nonribosomal peptide (PK/NRP) from a human oral probiotic, possessing a unique chemical structure and outstanding antibiotic activities. Although the biosynthetic gene cluster for salivabactin is known, the enzymatic logic that governs the synthesis of salivabactin has not yet been fully studied. In this work, we dissected the biosynthetic pathway for salivabactin using biochemical analysis. We successfully reconstituted the enzymatic synthesis of salivabactin in vitro, identified the minimal set of enzymes required for its biosynthesis, and revealed an unusual thioesterase domain involved in terminal olefin formation.

    View details for DOI 10.1021/acs.biochem.4c00515

    View details for PubMedID 39630928

    View details for PubMedCentralID PMC11652223

https://orcid.org/0009-0009-1324-4315