Brady David Hislop

All Publications

• Reply to I Jannasz et al: DIETFITS cohort, modeling, and molecules. The American journal of clinical nutrition Roberts, A. K., Panyard, D. J., Hislop, B., Ward, C. P., Snyder, M. P., Gardner, C. D., Haddad, F. 2026; 124 (1): 101351

  View details for DOI 10.1016/j.ajcnut.2026.101351

  View details for PubMedID 42386243

• Diet-Based Weight Loss Intervention is Not Associated with Meaningful Change in Lean Soft Tissue. The American journal of clinical nutrition Roberts, A. K., Panyard, D. J., Hislop, B., Ward, C. P., Snyder, M. P., Gardner, C. D., Haddad, F. 2026: 101251

  Abstract

  An emerging concern is that weight loss interventions can lead to disproportionate muscle loss. Few studies accurately quantify changes in lean soft tissue after weight loss or investigate associated molecular signatures.To quantify lean soft tissue (LST) change after a diet-based weight loss intervention. We also identify protein biomarkers associated with retention of LST.Using the DIETFITS cohort, we analyzed LST from dual-energy X-ray absorptiometry in three ways: a) by body region (appendicular and total body), b) after removing bias from fat-free adipose tissue (FFAT), and c) relative to body size (percentage predicted LST). We also assessed 242 proteins-measured in Olink Cardiovascular II, III, and Inflammation panels-as predictors of LST change.374 participants (61% female; age: 39.4 ± 6.7 yrs, BMI: 32.3 ± 3.2 kg/m2) previously randomized to healthy low-fat or low-carbohydrate diets were pooled and analyzed at baseline vs. 6 months. Total mass changed by -5.9 kg (95% CI: -6.51, -5.29 kg) in females and -7.18 kg (95% CI: -8.2, -6.16 kg) in males. Appendicular LST change was modest at -0.80 kg (95% CI: -0.92, -0.69 kg) in females and -1.02 kg (95% CI: -1.22, -0.83 kg) in males. Appendicular LST losses comprised <10% of total mass loss after adjusting for FFAT. Appendicular LST relative to body size also increased at 6 months (p<0.001). Change in 10 proteins in females and 27 proteins in males predicted LST change (5% FDR), with protein delta homolog 1 (DLK1)-an inhibitor of adipogenesis-as the top predictor.Change in appendicular LST-a surrogate for skeletal muscle-was modest after 6 months of diet-based weight loss. DLK1, an inhibitor of adipogenesis, emerged as the top protein biomarker linked to LST retention.NCT01826591. https://clinicaltrials.gov/study/NCT01826591?term=DIETFITS&rank=1.

  View details for DOI 10.1016/j.ajcnut.2026.101251

  View details for PubMedID 41740726

• Modifiable Factors Affecting the Postprandial Glycemic Response. Journal of diabetes science and technology Wu, Y., McLaughlin, T., Gorgani, S., Scheideman, A. F., Shao, M. M., Hislop, B. D., Hoang, K., Perelman, D., McGinity, C., Rodgar, M., Park, H., Wang, T., Mayer, C., DuNova, A., Ayers, A., Ho, C., Ræder, H., Klonoff, D. C., Snyder, M. P. 2026: 19322968261418614

  Abstract

  The postprandial glycemic response (PPGR) is associated with diabetes and cardiovascular disease and is highly individualized. The PPGR is affected by both physiological and behavioral factors. Attention to the PPGR has dramatically increased recently with the widespread use of continuous glucose monitors. It is expected that individualized control of PPGRs will be important in the prevention of diabetes and its associated complications. In this article, we discuss six modifiable factors associated with the PPGRs, including (1) the glucoregulatory hormones, (2) gastric emptying, (3) salivary or pancreatic amylase, (4) diet, (5) physical exercise, and (6) sleep and circadian rhythm. Modifying these factors may allow for personalized intervention strategies to control the PPGR-to reduce the risk for cardiovascular disease in individuals with varying degrees of glycemia.

  View details for DOI 10.1177/19322968261418614

  View details for PubMedID 41660725