Bio-X
Showing 21-30 of 57 Results
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Mark Pegram
Susy Yuan-Huey Hung Professor
Current Research and Scholarly InterestsMolecular mechanisms of targeted therapy resistance in breast and other cancers
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Norbert Pelc
Boston Scientific Applied Biomedical Engineering Professor and Professor of Radiology, Emeritus
Current Research and Scholarly InterestsBroadly, Dr. Pelc is interested in the physics, engineering and mathematics of medical imaging, especially computed tomography, digital x-ray imaging, magnetic resonance imaging, and hybrid multimodality systems. His current research is concentrated in the development of computed tomography systems with higher image quality and dose efficiency, in the characterization of system performance, and in the development and validation of new clinical applications.
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Gary Peltz
Professor of Anesthesiology, Perioperative and Pain Medicine (Department Research)
Current Research and Scholarly InterestsThe laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments. We have developed a more efficient method for performing mouse genetic analysis, which has been used to analyze the genetic basis for 16 different biomedical traits. We are developing novel methods, and have developed a novel experimental platform that replaces mouse liver with functioning human liver tissue.
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Jon-Paul Pepper, MD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsFacial paralysis is a debilitating condition that affects thousands of people. Despite excellent surgical technique, we are currently limited by the regenerative capacity of the body. The mission of our research is to identify new treatments that improve current facial paralysis treatments. We do this by exploring the regenerative cues that the body uses to restore tissue after nerve injury, in particular through pathways of neurogenesis and nerve repair in small mammals.
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Claudia Katharina Petritsch
Associate Professor (Research) of Neurosurgery
On Partial Leave from 12/24/2024 To 10/31/2025Current Research and Scholarly InterestsThe Petritsch lab broadly investigates underlying causes for the intra-tumoral heterogeneity and immune suppression in brain tumors from a neuro-developmental perspective. Defective cell fate decisions fuel the intra-humoral heterogeneity and plasticity in human brain tumors and may contribute to immune suppression. We use patient-derived models as avatars to study how brain cells control the fate of their progeny, whereby we unravel novel points of vulnerabilities in brain tumor cells.
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Dmitri Petrov
Michelle and Kevin Douglas Professor in the School of Humanities and Sciences
Current Research and Scholarly InterestsEvolution of genomes and population genomics of adaptation and variation
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Suzanne Pfeffer
Emma Pfeiffer Merner Professor of Medical Sciences
Current Research and Scholarly InterestsThe major focus of our research is to understand the molecular basis of inherited Parkinson's Disease (PD). We focus on the LRRK2 kinase that is inappropriately activated in PD and how it phosphorylates Rab GTPases, blocking the formation of primary cilia in specific regions of the brain. The absence of primary cilia renders cells unable to carry out Hedgehog signaling that is critical for neuroprotective pathways that sustain dopamine neurons.
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Adolf Pfefferbaum
Professor of Psychiatry and Behavioral Sciences, Emeritus
Current Research and Scholarly InterestsDevelopment and application of magnetic resonance imaging approaches for in vivo studies of human and animal brain integrity in neurodegenerative conditions, including alcoholism, HIV infection, Alzheimer's disease, and normal aging
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Trung Hoang Minh Pham
Assistant Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsUncovering mechanisms of tissue immunity and immunophysiology during persistent infection
The immune system safeguards the health of complex organisms by rapidly eliminating invading pathogens, curbing infection-induced tissue disruptions, and maintaining tissue homeostasis. Many bacterial pathogens evade host antimicrobial mechanisms and persist in infected tissues at low levels for long periods of time even in the presence of innate and adaptive immune resistance. During persistent infection, the immune system simultaneously orchestrates antimicrobial responses to contain the pathogen, repairs damaged tissue, regulates nutrient resources, and maintains other tissue physiological functions to ensure host survival. Failure of any of these tasks leads to uncontrolled infection, devastating disease, and even death. The goals of our research are to understand:
1)What are the innate and adaptive immune cellular mechanisms that contain pathogens during persistent infection?
2)How are tissue physiological functions, such as tissue repair and nutrient regulation, maintained during persistent infection?
3)How do pathogens survive innate and adaptive antimicrobial mechanisms in infected tissues?
4)How does persistent infection impact host immunity to secondary infections of a similar or different pathogen?
Through investigating these fundamental questions, we may be able to decode the underlying cellular and molecular mechanisms that can be harnessed to eradicate infections, promote tissue resilience, and restore health after an infectious insult. We employ animal infection models and bring together immunology, tissue biology, microbiology, and genetics to uncover the mechanisms of tissue immunity and immunophysiology during persistent infection from the molecular to organismal level.
Current areas of research:
•Development, maintenance, and plasticity of macrophage functional diversity in infected tissue
•Tissue repair and nutrient regulation during persistent infection
•Cellular dynamics and bacterial persistence in lymphoid organs -
Harold Westley Phillips
Assistant Professor of Neurosurgery (Pediatric Neurosurgery)
BioH. Westley Phillips, MD is an Assistant Professor of Neurosurgery at Stanford University where he is a neurosurgeon-scientist specializing in pediatric neurosurgery with a special interest in epilepsy. Dr. Phillips received his undergraduate degree at Yale University where he was a member of the Varsity Football Team and received a Fulbright Scholarship. He completed an MD at the Perelman School of Medicine at the University of Pennsylvania, graduating with a certificate of distinction in the Clinical Neuroscience Training Program. He completed neurosurgical residency at UCLA where he received 2 years of NIH funding to investigate the genetic underpinnings of epilepsy. He received fellowship training in pediatric epilepsy surgery and genetics research at Boston Children’s Hospital as well as pediatric neurosurgery at the University of Pittsburgh Medical Center, Children’s Hospital of Pittsburgh before his arrival at Stanford. At Stanford, Dr. Phillips leads a molecular genetics laboratory and has a particular interest in defining and further understanding somatic mosaicism and its role in epileptogenesis. He has published manuscripts in leading academic journals including Nature: Genetics, JAMA Neurology, Journal of Neuroscience, Scientific Reports, Epilepsia and Neurology. He is dedicated to improving the treatment and outcomes for children with drug resistant epilepsy through innovative research and cutting-edge surgical techniques.