School of Engineering

Showing 11-20 of 163 Results

  • Steve Bonilla

    Steve Bonilla

    Ph.D. Student in Chemical Engineering, admitted Autumn 2012

    BioAs a researcher in the Herschlag lab at Stanford, I am working towards the development of a quantitative and predictive model of RNA folding. For this purpose, I use single-molecule fluorescence, small-angle X-ray scattering, and other experimental tools to dissect the structural and dynamic properties of RNA three-dimensional motifs. These 3D motifs are like LEGOS that build diverse and complex functional RNA machines such as the ribosome. The goal is to develop a general model of RNA folding from the understanding of the energetic properties of small recurring building blocks or motifs. Recently, I joined an ongoing collaboration between the Greenleaf and the Herschlag labs that uses next-generation high-throughput sequencing for the characterization of RNA structural motifs. This powerful high-throughput approach developed in the Greenleaf lab allows dissection of the thermodynamic and kinetic properties of thousands of 3D motifs in parallel.

  • Matteo Cargnello

    Matteo Cargnello

    Assistant Professor of Chemical Engineering

    BioMatteo Cargnello is Assistant Professor of Chemical Engineering and Terman Faculty Fellow. His group research interests are in the preparation and use of uniform and tailored materials for heterogeneous catalysis and photocatalysis and the technological exploitation of nanoparticles and nanocrystals. Reactions of interest are related to sustainable energy generation and use, control of emissions of greenhouse gases, and better utilization of abundant building blocks (methane, biomass). Dr. Cargnello received his Ph.D. in Nanotechnology in 2012 at the University of Trieste (Italy) and he was then a post-doctoral scholar in the Chemistry Department at the University of Pennsylvania (Philadelphia) before joining the Faculty at Stanford. He is the recipient of the ENI Award Debut in Research 2013, the European Federation of Catalysis Societies Award as best European Ph.D. thesis in catalysis in 2013, and the Young Scientist Prize at the 16th International Congress on Catalysis in 2016.

  • Lynette Cegelski

    Lynette Cegelski

    Assistant Professor of Chemistry

    Current Research and Scholarly InterestsOur research program integrates chemistry, biology, and physics to investigate the assembly and function of macromolecular and whole-cell systems. The genomics and proteomics revolutions have been enormously successful in generating crucial "parts lists" for biological systems. Yet, for many fascinating systems, formidable challenges exist in building complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell factories. We are inspired by the need for new and unconventional approaches to solve these outstanding problems and to drive the discovery of new therapeutics for human disease.

    Our approach is different from the more conventional protein-structure determinations of structural biology. We employ biophysical and biochemical tools, and are designing new strategies using solid-state NMR spectroscopy to examine assemblies such as amyloid fibers, bacterial cell walls, whole cells, and biofilms. We would like to understand at a molecular and atomic level how bacteria self-assemble extracellular structures, including functional amyloid fibers termed curli, and how bacteria use such building blocks to construct organized biofilm architectures. We also employ a chemical genetics approach to recruit small molecules as tools to interrupt and interrogate the temporal and spatial events during assembly processes and to develop new strategies to prevent and treat infectious diseases. Overall, our approach is multi-pronged and provides training opportunities for students interested in research at the chemistry-biology interface.