School of Humanities and Sciences
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Christopher O. Barnes
Assistant Professor of Biology and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsResearch in our lab is aimed at defining the structural correlates of broad and potent antibody-mediated neutralization of viruses. We combine biophysical and structural methods (e.g., cryo-EM), protein engineering, and in vivo approaches to understand how enveloped viruses infect host cells and elicit antigen-specific immune responses. We are particularly interested in the co-evolution of HIV-1 and broadly-neutralizing IgG antibodies (bNAbs), which may hold the key to the development of an effective HIV-1 vaccine. In addition, we are investigating antibody responses to SARS-CoV-2 and related zoonotic coronaviruses (CoV), with the related goal of developing broadly-protective immunotherapies and vaccines against variants of concern and emerging CoV threats.
HIV-1; SARS-CoV-2; coronaviruses; cryo-EM; crystallography; vaccines; directed evolution -
Kathryn Barton
Associate Professor, Biology
Consulting Professor, BiologyCurrent Research and Scholarly InterestsPlants make new leaves and stems from clusters of undifferentiated cells located at the tips of branches. These cell clusters are called apical meristems. We study transcription factors that control growth and development of apical meristems. Our studies include plants growing in environments rich in water and nutrients as well as in poor environments. The deeper knowledge of plant development gained from these studies will ultimately help increase food security in a changing environment.
