School of Medicine
Showing 181-190 of 312 Results
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Yong Yean Kim
Assistant Professor of Pediatrics ( Hematology & Oncology)
BioOur lab is interested in translational science to bring new therapies to clinical trials. In particular, we are interested in pediatric sarcomas which have not had advancement in clinical treatment for decades. Current projects in the lab focus on understanding of the biology of fusion transcription factor PAX3::FOXO1 which is the driver mutation in fusion positive rhabdomyosarcoma. PAX3::FOXO1 is a powerful oncogenic transcription factor which rewires the transcriptional organization to lock the cancer cell in the proliferative state. Since transcription factors including PAX3::FOXO1 are difficult to target using small molecules, we aim to understand how PAX3::FOXO1 is regulated and targeting the regulators of PAX3::FOXO1. By understanding and targeting the regulation of PAX3::FOXO1, we hope to bring new therapies for fusion positive rhabdomyosarcoma. Additionally, these regulatory mechanisms may also be active in other transcription driven cancers such as the EWSR1::FLI1 driven Ewings Sarcoma.
Our lab is also interested in exploring the epigenetic landscape of pediatric solid tumors and trying to understand how dysregulation in the epigenome drives oncogenesis. We utilize various CRISPR mediated genetic techniques to interrogate the regulators of epigenome focusing on the histone lysine demethylases (KDMs). KDMs are an understudied group of epigenetic regulators which can be targeted for therapeutic effect. We explore the role of KDMs in pediatric solid tumors and hope to identify potential targets for drug development. -
Youn H Kim, MD
The Joanne and Peter Haas, Jr., Professor for Cutaneous Lymphoma Research and Professor, by courtesy, of Medicine (Oncology)
Current Research and Scholarly InterestsClinical research in cutaneous lymphomas, especially, mycosis fungoides; studies of prognostic factors, long-term survival results, and effects of therapies. Collaborative research with Departments of Pathology and Oncology in basic mechanisms of cutaneous lymphomas. Clinical trials of new investigative therapies for various dermatologic conditions or clinical trials of known therapies for new indications.
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Benyam Z. Kinde, MD, PhD
Assistant Professor of Ophthalmology
BioDr. Kinde is a board-certified, fellowship-trained ophthalmologist and ophthalmic plastic and reconstructive surgeon at Stanford Health Care Byers Eye Institute. He is also an assistant professor in the Department of Ophthalmology at Stanford University School of Medicine. Dr. Kinde completed the American Society of Ophthalmic and Plastic Reconstructive Surgery (ASOPRS) fellowship in ophthalmic plastic surgery through the Bascom Palmer Eye Institute at the University of Miami.
Dr. Kinde diagnoses and treats a wide range of conditions related to the eyelid and other eye structures, including facial nerve palsy, skin cancer, and thyroid eye disease. He also provides care for patients who wish to enhance their appearance through surgical and nonsurgical interventions. Dr. Kinde offers many types of treatments, including cosmetic surgery, eyelid surgery (including upper and lower eyelid blepharoplasty and ptosis surgery), reconstructive surgery, tear duct (lacrimal) surgery, and orbital surgery.
Dr. Kinde is a physician-scientist whose research interests focus on developing new tools to promote survival of retinal ganglion cells after optic nerve injury. He has investigated how modulating the DNA damage response in mouse models of traumatic optic neuropathy (symptoms of nerve damage) may promote and improve optic nerve function after injury. His previous work focused on increasing the resilience of neurons (messaging nerve cells) in mouse models of glaucoma and in humans with glaucoma. He completed his MD and PhD in neuroscience at Harvard Medical School, where his thesis work revealed a new understanding of Rett syndrome, a rare genetic disorder that affects body movement.
Dr. Kinde has published in many peer-reviewed journals, including Nature, Science, Cell, Ophthalmology, and Facial Plastic Surgery & Aesthetic Medicine. He has presented to his peers at international and national meetings, including the Association for Research in Vision and Ophthalmology, American Society of Ophthalmic Plastic and Reconstructive Surgery, and Inter-American Course in Clinical Ophthalmology. -
Abby C. King
David and Susan Heckerman Professor and Professor of Epidemiology & Population Health and of Medicine (Stanford Prevention Research Center)
Current Research and Scholarly InterestsMy interests include applications of behavioral theory and social ecological approaches to achieve large scale changes impacting chronic disease prevention and control; expanding the reach and translation of evidence-based interventions through state-of-the-art technologies; exploring social and physical environmental influences on health; applying community participatory research perspectives to address health disparities; and policy-level approaches to health promotion/disease prevention.
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Roy King
Associate Professor of Psychiatry and Behavioral Sciences, Emeritus
Current Research and Scholarly InterestsCurrent research centers on the use of human genetic haploid systems, e.g. the Y chromosome, to understand the prehistory of human migrations particularly since the Holocene. This work includes investigating correlations with human symbolic material culture, focusing on the visual artistic realm. Also being explored are the issues and ethical implications of the social construction of race and ethnicity vis a vis the enhanced capacity to differentiate populations using genotypes.
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David Kingsley
Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine
Current Research and Scholarly InterestsWe use mice, stickleback fish, and humans to study the molecular basis of evolution and common diseases. By combining genetics and genomics, we have identified key DNA changes that control bone formation, limb patterning, hair color, brain evolution, and susceptibility to arthritis, schizophrenia, and bipolar disorder. We find that the same genetic mechanisms are often used repeatedly in nature, providing new insights into the origin of key traits in many different species, including ourselves.
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Lucas Kipp
Clinical Associate Professor, Adult Neurology
BioDr. Kipp specializes in the diagnosis and treatment of neuroimmunological disorders, particularly demyelinating conditions such as multiple sclerosis and neuromyelitis optica. He is interested in translational research connecting expert MS clinicians, world-renown immunology laboratories, and advanced neuroimaging techniques to identify biomarkers of disease and treatment response.
