School of Medicine

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  • William Hiesinger, MD

    William Hiesinger, MD

    Associate Professor of Cardiothoracic Surgery (Adult Cardiac Surgery)

    BioDr. Hiesinger is a board-certified, fellowship-trained specialist in adult cardiac surgery. He is also an associate professor in the Department of Cardiothoracic Surgery at Stanford University School of Medicine.

    Dr. Hiesinger’s clinical focus encompasses the full spectrum of cardiothoracic conditions and treatment approaches, such as heart transplantation, mitral and aortic valve repair, surgical treatment for hypertrophic cardiomyopathy, coronary artery bypass, pulmonary thromboendarterectomy (PTE), and complex thoracic aortic procedures. He serves as Surgical Director of the Stanford Mechanical Circulatory Support Program, where he leads and directs the surgical implantation of ventricular assist devices (VADs) in patients with end-stage heart failure. He also serves as Surgical Director for the Stanford Hypertrophic Cardiomyopathy Center and the Stanford Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Program.

    The National Institutes of Health and the Thoracic Surgery Foundation have awarded funds to support Dr. Hiesinger’s research. In the Stanford Cardiothoracic Therapeutics and Surgery Laboratory, Dr. Hiesinger's research spans the disciplines of computer science and cardiovascular biology, and he endeavors to build novel foundational deep learning systems designed to better represent and process high-dimensional inputs and apply these systems towards clinical problems. Additionally, his lab investigates bioengineered devices, tissue engineering, and angiogenic cytokine therapy for the treatment of heart failure.

    He has published extensively and his work has appeared in Nature Communications, Nature Machine Intelligence, the Journal of Heart and Lung Transplantation, Circulation Heart Failure, the Journal of Thoracic and Cardiovascular Surgery, Journal of Vascular Surgery, and elsewhere.

    He teaches courses on cardiothoracic surgery skills. He also advises surgeons of the future.

    Dr. Hiesinger has won awards for his research and scholarship, including the Surgical Resident of the Year Award, Jonathan E. Rhoads Research Award, Clyde F. Baker Research Prize, and I.S. Ravdin Prize, all from his alma mater, the University of Pennsylvania. He was a finalist for the Vivien Thomas Young Investigator Award from the American Heart Association.

    Dr. Hiesinger is a member of the American Association for Thoracic Surgery and serves on the Cardiac Surgery Biology Club. He is also a member of the Society of Thoracic Surgeons and serves on the American Heart Association Council for Cardiothoracic and Vascular Surgery.

  • Tzu-Yen Huang （黃子晏）

    Tzu-Yen Huang （黃子晏）

    Affiliate, Cardiothoracic Surgery
    Visiting Scholar, Cardiothoracic Surgery - Adult Cardiac Surgery

    BioTzu-Yen Huang, MD, PhD, is a cardiovascular surgeon and clinician-scientist whose work bridges cardiovascular surgery, biomedical engineering, and translational research. He is currently a Visiting Scholar in Cardiothoracic Surgery at Stanford University and an attending physician in Thoracic and Cardiovascular Surgery at Chang Gung Memorial Hospital in Taiwan.

    Dr. Huang received his MD from Chung Shan Medical University and completed his PhD training in Biomedical Engineering at National Taiwan University. His clinical practice encompasses coronary and valvular surgery, aortic and endovascular surgery, and mechanical circulatory support, including ECMO and ECPR. His research focuses on translating engineering and biomaterials approaches into solutions for cardiovascular surgery, with particular interests in vascular biomaterials, intimal hyperplasia, extracorporeal heart perfusion, myocardial preservation, and heart transplantation.

    His translational biomaterials research has developed drug-functionalized vascular sutures and local drug-delivery platforms designed to modulate thrombosis, vascular smooth muscle cell responses, and neointimal hyperplasia. This work has resulted in peer-reviewed publications and patents, including technologies involving mitomycin C–functionalized polypropylene sutures and bivalirudin-loaded hydrogel systems. His research has been published in journals including the International Journal of Biological Macromolecules, International Journal of Molecular Sciences, World Journal of Emergency Surgery, and BMC Cardiovascular Disorders.

    Dr. Huang's work has received recognition from cardiovascular and biomaterials research communities, including the Young Investigator Award of the Taiwan Society of Cardiology, the Asian Pacific Grants for Innovative Research Plans of the Japanese Circulation Society, a Young Investigator Competition Award finalist distinction at ISOMRM, and two Gold Awards at the International Innovation and Invention Competition.

    At Stanford, his current research extends this translational engineering approach to cardiac transplantation and ex vivo heart perfusion, with an emphasis on developing physiologically informed perfusion and preservation strategies. His long-term goal is to integrate cardiovascular surgery, engineering, and translational science to develop technologies that improve vascular reconstruction, organ preservation, and outcomes in advanced cardiovascular disease.