Maternal & Child Health Research Institute (MCHRI)
Showing 31-40 of 70 Results
-
Nasim Sabery Khavari
Clinical Associate Professor, Pediatrics - Gastroenterology
Current Research and Scholarly InterestsPediatric Gastroenterology, Celiac Disease, Nutrition in Celiac Disease
-
Paul A. Khavari, MD, PhD
Carl J. Herzog Professor of Dermatology in the School of Medicine
Current Research and Scholarly InterestsWe work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.
-
Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Grace S. Kim, MD
Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS)
BioGrace S. Kim, MD is a pediatric otolaryngologist and surgeon-scientist in the Department of Otolaryngology–Head & Neck Surgery at Stanford University. Her clinical practice focuses on the full spectrum of pediatric otolaryngology, with particular expertise in hearing loss, chronic ear disease, thyroid disorders, vascular malformations and pediatric head and neck conditions. Her research investigates the immune mechanisms underlying congenital hearing loss and inner ear injury, with the goal of developing therapies to preserve hearing in children.
Dr. Kim received her BA in Biochemical Sciences from Harvard University and her MD from Stanford University School of Medicine, where she also completed an additional year of research as a Howard Hughes Medical Institute Research Fellow. She completed residency training in otolaryngology–head and neck surgery at Stanford, including a two-year NIH-sponsored research fellowship investigating vestibular repair and regeneration, followed by fellowship training in complex pediatric otolaryngology at Stanford.
Dr. Kim joined the Stanford faculty in 2023. She leads a translational research program investigating inner ear neuroimmunology and congenital hearing loss, using animal models to understand how congenital cytomegalovirus infection and immune responses impact the developing auditory system. Her long-term goal is to develop targeted therapies that prevent hearing loss in children. Her work is supported by an NIH Mentored Clinical Scientist Research Career Development (K08) Award, as well as funding from the American Society of Pediatric Otolaryngology and the Stanford Maternal & Child Health Research Institute.
