School of Medicine
Showing 191-200 of 234 Results
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N. Lance Downing
Clinical Assistant Professor, Medicine
BioI am board-certified internal medicine and clinical informatics. I am a primary care physician and teaching hospitalist. I have published work in the New England Journal of Medicine, Health Affairs, Annals of Internal Medicine, and the Journal of the American Medical Informatics Association. My primary focus throughout my career has been to deliver personalized and compassionate care that incorporates the latest advancements in medical science. I aim to help all of my patients maximize their healthspan and age with the best quality of life possible.
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Zachary B. Dozier
Assistant Professor of Pediatrics (Clinical Informatics) and of Medicine (Computational Medicine)
BioZach Butzin-Dozier is an Assistant Professor in the Department of Pediatrics, Division of Clinical Informatics, with a joint appointment in the Department of Medicine, Division of Computational Medicine. His research applies machine learning and artificial intelligence for causal inference via electronic health record data. He draws from large-scale databases, such as Epic Cosmos, PEDSnet, and the National Clinical Cohort Collaborative, to answer pressing questions in pediatric and infectious disease medicine. His research evaluates vaccine effectiveness, drug repurposing, and the long-term sequelae of viral infection, including Long COVID. He aims to bridge rigorous biostatistical methodology with clinically meaningful research questions. He received his PhD in Epidemiology and MPH from UC Berkeley, and he is an NIAID K01 recipient.
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Ron Dror
Cheriton Family Professor and Professor, by courtesy, of Structural Biology and of Molecular & Cellular Physiology
Current Research and Scholarly InterestsMy lab’s research focuses on computational biology, with an emphasis on 3D molecular structure. We combine two approaches: (1) Bottom-up: given the basic physics governing atomic interactions, use simulations to predict molecular behavior; (2) Top-down: given experimental data, use machine learning to predict molecular structures and properties. We collaborate closely with experimentalists and apply our methods to the discovery of safer, more effective drugs.
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David Drover
Professor of Anesthesiology, Perioperative and Pain Medicine (MSD), Emeritus
Current Research and Scholarly InterestsField of clinical pharmacology. This involves analysis of what the body does to a drug (pharmacokinetics) and how exactly a specific drug affects the body (pharmacodynamics). His research starts at the level of new drug development with detailed analysis of the pharmacokinetics and pharmacodynamics of a medication.
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Shaul Druckmann
Associate Professor of Neurobiology, of Psychiatry and Behavioral Sciences and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsOur research goal is to understand how dynamics in neuronal circuits relate and constrain the representation of information and computations upon it. We adopt three synergistic strategies: First, we analyze neural circuit population recordings to better understand the relation between neural dynamics and behavior, Second, we theoretically explore the types of dynamics that could be associated with particular network computations. Third, we analyze the structural properties of neural circuits.
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Maurice L. Druzin
Professor of Obstetrics and Gynecology (Maternal Fetal Medicine and Obstetrics), Emeritus
Current Research and Scholarly InterestsAntepartum and intrapartum fetal monitoring Prenatal diagnosis Medical complications of pregnancy, particularly: SLE, hypertension, diabetes, malignancy A.
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Tianwei Du
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
BioDr. Du's clinical interests focus on providing evidence-based treatment to individuals with emotion dysregulation, interpersonal difficulties, and/or complex trauma. She is also passionate about addressing diversity factors in clinical work. Dr. Du provides services in the Dialectical Behavior Therapy (DBT) Adult Program, Stanford Mental Health for Asians Research and Treatment (SMHART) Clinic, and the Anxiety and Depression Adult Psychological Treatment (ADAPT) Clinic. Dr. Du is a bilingual clinician speaking English and Mandarin.
Dr. Du's research focuses on exploring the roles of interpersonal processes and personality in psychopathology, and she has published widely on this topic. Dr. Du also participated in a variety of clinical trials to help develop and improve evidence-based interventions for individuals with complex clinical presentations and populations with limited access to mental health care. -
Justin Du Bois
Henry Dreyfus Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
BioThe Du Bois lab is heavily invested in exploring voltage-gated ion channel function and physiology and the underlying role of specific channels in human pathologies, particularly nociception, epilepsy, and neurodevelopmental disorders. With expertise in chemical synthesis, we have access to a collection of exceptional natural products—tetrodotoxin, saxitoxin, gonyautoxin, batrachotoxin, veratridine, antillatoxin, to name a few—that act as selective modulators of sodium ion channels (NaVs). In addition, we have developed novel molecules as inhibitors and agonists of specific voltage-gated chloride (ClCs) and calcium (CaVs) channel isoforms. As a lab, we are uniquely positioned to advance high-precision chemical tools to interrogate underlying biochemical mechanisms of electrogenesis. Our work in this arena is guided by a number of questions related to the basic functioning of voltage-gated channels in neuronal cells and glia that include: 1) what is the rate at which channels are being made and degraded and is the rate of channel turnover context dependent (i.e., is protein turnover affected by increased neuronal activity, nerve cell damage, etc.); 2) to what extent is channel expression and cellular distribution affected by external factors (pH, inflammatory modulators, injury); 3) how do post-translational protein modifications influence channel function and how are such modifications altered in response to external factors; 4) how do neighboring glia influence channel expression and ion gating. Answers to these types of questions will provide a deeper understanding of the molecular mechanisms by which neuronal cells and tissue respond to external stimuli, stress, and injury. We benefit from the strong interest of others in our work and multiple collaborators at Stanford and at other institutions.
Ion channel function and physiology. We wish to understand the role of individual subtypes of voltage-gated sodium, chloride, and calcium channels in neuronal signaling and how structural changes (i.e., point mutations, post-translational modifications, partner proteins) alter channel function. Our interests include the design, development, and application of chemogenetic technologies for targeting individual channel subtypes and allosteric modulators of select channel isoforms. Our work aims to inform efforts in translational research, as voltage-gated ion channel dysregulation and malfunction underlie a wide range of human diseases and disorders.
Natural products synthesis. We are interested in developing efficient and flexible synthetic routes to natural products that serve as ‘lead’ compounds for advancing high precision pharmacological tools. Most of the targets we are interested in obtaining are not available in sufficient quantities from natural sources, thus necessitating de novo preparation. To streamline the assembly process of these complex molecules, we are challenged to develop, in parallel, new tactics and chemical methods that facilitate C–C, C–N, and C–O bond formation.
Toxin ‘sponge’ proteins. A longstanding collaboration with the Minor lab at UCSF has focused on understanding how certain organisms that ingest dietary toxins such as saxitoxin, tetrodotoxin, and batrachotoxin survive their poisonous effects. This work has resulted in the elucidation of the structures of novel paralytic shellfish-binding proteins (so-called saxiphilins) and the toxin ‘binding code’. Studies are ongoing to integrate saxiphilins into a diagnostic device for measuring toxin concentrations in shellfish and to advance an engineered toxin-binding protein as a countermeasure for paralytic shellfish poisoning. -
Monica M. Dua, MD
Clinical Professor, Surgery - General Surgery
Current Research and Scholarly InterestsTechnical aspects of minimally invasive pancreatic and liver surgery
Minimally invasive strategies for the management of pancreatic necrosis
Management of severe acute pancreatitis – academic vs community treatment
Multidisciplinary treatment of HCC; institutional barriers to appropriate referral/ care
Endocrine/exocrine insufficiency after pancreatectomy; volumetric assessment
Natural history and management of pancreatic cysts
