School of Medicine
Showing 1-6 of 6 Results
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Laura Attardi
Catharine and Howard Avery Professor of the School of Medicine and Professor of Genetics
Current Research and Scholarly InterestsOur research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse.
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Richard Frock
Assistant Professor of Radiation Oncology (Radiation and Cancer Biology)
Current Research and Scholarly InterestsWe are a functional genomics laboratory interested in elucidating mechanisms of DNA repair pathway choice and genome instability. We use genome-wide repair fate maps of targeted DNA double strand breaks (DSBs) to develop pathway-specific models and combinatorial therapies. Our expertise overlaps many different fields including: genome editing, ionizing radiation, cancer therapeutics, V(D)J and IgH class switch recombination, repair during transcription and replication, and meiosis.
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Amato J. Giaccia
Jack, Lulu and Sam Willson Professor, Professor of Radiation Oncology, Emeritus
Current Research and Scholarly InterestsDuring the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically.
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Mohammad Shahrokh Esfahani
Assistant Professor of Radiation Oncology (Radiation and Cancer Biology)
BioWith a primary focus on high-dimensional data, I have significant expertise in developing machine learning tools. Much of my work involves constructing Bayesian models, which effectively convert 'prior knowledge', either inherent in the dataset or obtained from external sources, into mathematical terms—more specifically, prior probabilities.
My recent research efforts have centered on the analysis of genetic and epigenetic signals within cell-free DNA assays. This interest in epigenetics led to the development of a pioneering technique known as EPIC-seq, which has broadened our understanding of this complex field.
It's notable that traditional computational methods in cancer genomics often fall short when confronted with an exceedingly low signal-to-noise ratio—a common scenario in cfDNA analyses. As such, there's an emerging need to devise innovative, robust methods capable of overcoming this limitation—a research area that I'm deeply committed to and actively engaged in. -
Jiangbin Ye
Assistant Professor of Radiation Oncology
Current Research and Scholarly InterestsOne hallmark of cancer is that malignant cells modulate metabolic pathways to promote cancer progression. My professional interest is to investigate the causes and consequences of the abnormal metabolic phenotypes of cancer cells in response to microenvironmental stresses such as hypoxia and nutrient deprivation, with the prospect that therapeutic approaches might be developed to target these metabolic pathways to improve cancer treatment.
