School of Medicine
Showing 91-100 of 4,789 Results
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Derek F. Amanatullah, M.D., Ph.D.
Associate Professor of Orthopaedic Surgery
BioDr. Amanatullah specializes in hip and knee replacements for individuals with osteoarthritis, rheumatoid arthritis, infectious arthritis and avascular necrosis. He also performs revision surgeries of knee and hip implants with problems.
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Manuel R. Amieva
Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsMy laboratory studies how bacteria colonize our bodies for long periods of time, and how interactions between bacteria and the epithelial surfaces of the gastrointestinal tract and skin may lead to disease. Epithelial surfaces are the first barrier against infection, but they also where our bodies meet and co-evolve with the microbial world.. Several of our studies have focused on the epithelial junctions as a target for bacterial pathogens. The host epithelium uses its epithelial junctions to form a tight but dynamic barrier with an external surface that is inhospitable to microbial attachment, secretes anti-microbial compounds, and has a rapid rate of self-renewal. The balance in the microbe-epithelial relationship results in silent commensalism or symbiosis; an imbalance results in diseases ranging from acute bacterial invasive disease to chronic ulcers or carcinoma.
Our laboratory has developed novel microscopy applications such as quantitative 3D confocal microscopy, electron microscopy, time-lapse imaging, microinjection and micromanipulation to visualize the interaction of pathogens with epithelial cells in culture and in animal and human tissues. Many of out studies focus on the gastric pathogen Helicobacter pylori, but we have also expanded our investigations to include the intestinal pathogens Listeria monocytogenes and Salmonella enterica, and the skin pathogen and colonizer Staphylococcus aureus. I believe that elucidating how microbes communicate with and alter our epithelial cells at a molecular level will be important for finding novel therapeutic targets to control mucosal colonization and prevent invasive disease.
Using this perspective, we have uncovered several novel concepts of how bacteria colonize and breach our epithelial surfaces. For example, we discovered that Helicobacter pylori target the intercellular junctions, and in particular that the virulence factor CagA affects junction assembly and cell polarity. This confers H. pylori the ability to extract nutrients and grow directly on the epithelial surface. We also found that these properties of CagA have consequences for cellular transformation of the epithelium. For instance, we showed that H. pylori affect the activity and state of epithelial stem cells in the stomach by colonizing the epithelial surface deep in the gastric glands. This gland-associated population is essential for pathological inflammation and hyperplasia in animal models, and confers significant colonization advantages to the bacteria. Our Listeria research uncovered a new mechanism and site where bacteria can breach the gastrointestinal epithelial barrier to invade. We found that Listeria find their receptor for invasion at sites of epithelial senescence, where the epithelial junctions undergo dynamic turnover. To study Salmonella and H. pylori we have developed a human organoid model to study their interactions with human gut epithelium in vitro. To study Staphylococcus aureus pathogenesis, we have developed methods to visualize infection at the scale of a single bacterial microcolony using an organoid culture system of human keratinocytes and fibroblasts that grow into a 3D skin-equivalent. We recently identified several proteins at the eptithelial junctions as host factors involved in the pathogenesis of one of Staphylococcus aureus major toxins. -
Neal Amin
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
BioDr. Neal D. Amin's research findings on gene regulatory mechanisms in the human nervous system have been the basis of articles in top journals, patents, awards, and research funding. He is corresponding author on works identifying cell type-specific RNA processing changes implicated in neurodegeneration. Other products of his research include a sole-author patent on gene delivery, speaking engagements at national and international conferences, and recognition and significant research funding from the NIH and private foundations including the BBRF and the Deeda Blair Research Initiative. His work applies advanced single cell transcriptomics, mice and human brain organoids, and deep learning models to identify gene regulatory network hubs associated with a wide range of diseases.
Dr. Amin is a Clinical Assistant Professor in the Department of Psychiatry at Stanford University where he leads fundamental wet and dry lab research into brain development and disease. He an attending physician in Stanford's Evaluation Clinic where he continues to see patients. He completed the Research Track Psychiatry Residency Program at Stanford University and is a board-certified psychiatrist and his postdoctoral studies with Sergiu Pasca, MD. He earned MD and PhD degrees from the University of California, San Diego with his graduate mentor Samuel L. Pfaff, PhD, at the Salk Institute for Biological Studies in La Jolla, CA. He also holds a Bachelor of Arts from Columbia College, Columbia University. -
Michael Amylon
Professor of Pediatrics (Hematology/Oncology) at the Lucile Salter Packard Children's Hospital, Emeritus
Current Research and Scholarly InterestsBone marrow transplantation (BMT) is a treatment modality which is being broadly applied to a growing number of disorders. Increasing success with BMT is offering improved survival to pediatric and adult patients with acute leukemia, chronic leukemia, lymphomas, and a variety of solid tumors as well as severe aplastic anemia.
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Tonya Wei An, MD
Clinical Assistant Professor, Orthopaedic Surgery
BioDr. An is a fellowship-trained orthopaedic surgeon specializing in foot and ankle surgery. She provides care at Stanford Health Care locations in Emeryville and Pleasanton.
Her practice focuses on the diagnosis and treatment, both nonsurgical and surgical, of foot and ankle conditions, including sports injuries, flatfoot deformity, and ankle arthritis. Working with world-class experts at the Hospital for Specialty Surgery, Dr. An is trained in the latest techniques and technologies, ranging from cartilage repair, minimally invasive bunion correction, to total ankle replacement.
Dr. An is passionate about practicing evidence-based medicine and pursuing research to advance the field of foot and ankle surgery. She works as part of a team with other orthopedic specialists, neurologists, physiatrists, and therapists to help patients achieve the best clinical outcomes. Dr. An believes in understanding each individual’s circumstances and goals to create a personalized care plan. When surgery is deemed the best option, Dr. An guides her patients through every step of getting back on their feet.
Dr. An has been involved in extensive research studying clinical outcomes after surgical correction of foot deformities caused by Charcot-Marie-Tooth disease, a hereditary condition that results in weaker and smaller muscles. Her work has appeared in several peer-reviewed scientific journals, including Foot & Ankle International and the Journal of Foot and Ankle Surgery, among others. She has also written textbook chapters on flatfoot and bunion surgical techniques, metatarsalgia (pain in the ball of the foot), and Lisfranc (midfoot) injuries.
Dr. An is a licensed physician in California and New York. She is a member of the Western Orthopaedic Association, American Orthopaedic Foot and Ankle Society (AOFAS), American Academy of Orthopedic Surgeons, and the American Medical Association. She advocates for diversity in the field of medicine and has served organizations such as the Committee on Inclusion, Equity and Advancement and Women in Orthopaedics Outreach Group at her prior institution. -
Kanwaljeet S. Anand
Professor of Pediatrics (Pediatric Critical Care) and of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsDr. Anand is a translational clinical researcher who pioneered research on the endocrine-metabolic stress responses of infants undergoing surgery and developed the first-ever scientific rationale for pain perception in early life. This provided a framework for newer methods of pain assessment, numerous clinical trials of analgesia/anesthesia in newborns, infants and older children. His research focus over the past 30+ years has contributed fundamental knowledge about pediatric pain/stress, long-term effects of pain in early life, management of pain, mechanisms for opioid tolerance and withdrawal. Current projects in his laboratory are focused on developing biomarkers for repetitive pain/stress in critically ill children and the mechanisms underlying sedative/anesthetic neurotoxicity in the immature brain. He designed and directed many randomized clinical trials (RCT), including the largest-ever pediatric analgesia trial studying morphine therapy in ventilated preterm neonates. He has extensive experience in clinical and translational research from participating in collaborative networks funded by NIMH, NINDS, or NICHD, a track-record of excellent collaboration across multiple disciplines, while achieving success with large research teams like the Collaborative Pediatric Critical Care Research Network (CPCCRN). He played a leadership roles in CANDLE (Condition Affecting Neuro-Development & Learning in Early infancy) and other activities of the Urban Child Institute and UT Neuroscience Institute. More recently, he led the NeoOpioid Consortium funded by the European Commission, which collected data from 243 NICUs in 18 European countries.
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Shuchi Anand
Associate Professor of Medicine (Nephrology)
Current Research and Scholarly InterestsManagement of CKD and ESRD in low-resource settings
Tubulointerstitial disease
Chronic kidney disease of unknown etiology
ESRD and physical activity
ESRD and vitamin D deficiency -
Chad Anderson
Clinical Assistant Professor, Medicine - Primary Care and Population Health
BioChad Anderson is a Physician Assistant at Stanford ValleyCare and a Clinical Assistant Professor with the Stanford School of Medicine MSPA program. He is the Assistant Director of PA education at ValleyCare. He is dual credentialed as a Family Nurse Practitioner and a Physician Assistant. He completed his FNP/PA training at the Stanford School of Medicine and his graduate studies at A.T. Still University – Arizona School of Health Sciences. He is passionate about improving our patients hospital experience as well as educating our future providers.
