School of Medicine
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Jong H. Yoon
Professor of Psychiatry and Behavioral Sciences (Public Mental Health & Population Sciences)
Current Research and Scholarly InterestsMy research seeks to discover the brain mechanisms responsible for schizophrenia and to translate this knowledge into the clinic to improve how we diagnose and treat this condition. Towards these ends, our group has been developing cutting-edge neuroimaging tools to identify neurobiological abnormalities and test novel systems-level disease models of psychosis and schizophrenia directly in individuals with these conditions.
We have been particularly interested in the role of neocortical-basal ganglia circuit dysfunction. A working hypothesis is that some of the core symptoms of schizophrenia are attributable to impairments in neocortical function that results in disconnectivity with components of the basal ganglia and dysregulation of their activity. The Yoon Lab has developed new high-resolution functional magnetic resonance imaging methods to more precisely measure the function of basal ganglia components, which given their small size and location deep within the brain has been challenging. This includes ways to measure the activity of nuclei that store and control the release of dopamine throughout the brain, a neurochemical that is one of the most important factors in the production of psychosis in schizophrenia and other neuropsychiatric conditions. -
Luke Yoon, MD
Clinical Associate Professor, Radiology
BioLuke Yoon, MD, is a Clinical Associate Professor and Associate Chair of Faculty Well-being and Development in the Department of Radiology at Stanford University School of Medicine. Dr. Yoon is a radiologist specializing in body imaging and musculoskeletal imaging. A graduate of Yale College and Yale School of Medicine, Dr. Yoon completed his post-graduate training at Harvard affiliated hospitals: internal medicine internship at Brigham and Women’s Hospital, and radiology residency and fellowship at Massachusetts General Hospital. Prior to joining Stanford Radiology, Dr. Yoon worked as an attending radiologist at Brigham and Women’s Hospital, Singleton Associates, and Baylor College of Medicine. His clinical interests include physician well-being, cystic renal mass imaging, and liver mass classification.
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Kyan Younes, MD
Clinical Assistant Professor, Adult Neurology
BioDr. Younes is a fellowship-trained, board-certified neurologist and a clinical assistant professor in the Department of Neurology at Stanford University School of Medicine.
His areas of expertise include the diagnosis and treatment of Alzheimer’s disease, frontotemporal dementia, primary progressive aphasia, Lewy body dementia, normal pressure hydrocephalus and cognitive and behavioral impairments. For each patient, Dr. Younes develops a personalized plan of care. A plan may include his close collaboration with experts from psychiatry, nursing, pharmacy, genetic counseling, and other specialties. His goal is to ensure that each patient receives care that is both comprehensive and compassionate.
To help lead advances and innovations in his field, Dr. Younes conducts extensive research. He is studying the clinical, neuropsychological, socioemotional, genetic, and pathological features when a patient experiences degeneration of the right anterior temporal lobe area of the brain. This disorder can affect a person’s ability to process emotions and person-specific knowledge.
He also is researching how multimodal brain imaging, including magnetic resonance imaging (MRI) and Positron Emission Tomography (PET) combined with machine learning can help improve the detection of neurodegenerative diseases. In other research, he has participated in clinical trials of new drug therapies for Alzheimer’s disease.
Dr. Younes has presented research findings at meetings of the American Neurological Association, American Academy of Neurology, and American Psychiatric Association. Topics have included predictors of cognitive performance in dementia.
He has co-authored research articles published in the American Journal of Psychiatry, Annals of Clinical and Translational Neurology, Journal of Neuroimaging, and elsewhere. Subjects of these articles have included guidelines for diagnosing the effects of right anterior temporal lobe degeneration on behavior, treatment for symptoms of encephalitis, and the impact of mild traumatic brain injury on healthy older adults.
Dr. Younes has written chapters on frontotemporal dementia for Psychiatric Clinics as well as the epilepsy, coma, acute ischemic stroke, meningitis and encephalitis chapters for the textbook The Little Black Book of Neurology.
He is a member of the American Academy of Neurology, American Neurological Association, Alzheimer’s Association, and International Society for Frontotemporal Dementias. -
Shady Younis
Instructor, Medicine - Immunology & Rheumatology
BioShady Younis, PhD is an instructor at the division of Immunology and Rheumatology at Stanford University. He received his PhD in Medical Sciences from Uppsala University in Sweden. He later joined Dr. William Robinson’s Lab at Stanford University as Wallenberg postdoctoral fellow, where he characterized the pathogenic role of cytotoxic CD8+ T cells in rheumatoid arthritis. His current research aimed at elucidating the underlying triggers of pathogenic B cell responses in a spectrum of autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). He uses computational methodologies alongside cutting-edge high-throughput sequencing technologies to characterize the autoreactive B and T cells. The overarching research objective of his research is to unravel the mechanistic roles of Epstein-Barr Virus (EBV) reactivation in activating and transforming autoreactive B cells in the development of autoimmunity.
