School of Medicine
Showing 21-30 of 49 Results
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Yuhao (Danny) Huang
Postdoctoral Scholar, Neurosurgery
Resident in Graduate Medical EducationBioI am a resident and post-doctorate researcher in the Department of Neurosurgery at Stanford University. As a physician-scientist with a focus on signal processing and neural electrophysiology, I work with multimodal datasets to understand how brain signals correlate with human behavior. I am interested in using computer vision and machine learning to parse neural correlates of behavior under naturalistic settings. Another area of interest involves building robust neuro-modulatory treatments for functional disorders and epilepsy. I received my BSc at University of Alberta and my MD at Stanford University.
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Duc Tan Huynh
Postdoctoral Scholar, Neurosurgery
BioAs a cell biologist interested in neuroscience, I am fascinated about the molecular basis of nervous system disorders that reveal therapeutic targets and/or biomarkers. My long-term research goal is to identify strategies that revert dysregulation in aging or neurodegeneration. For my postdoctoral training in the Zuchero lab (Neurosurgery), I will investigate how myelination, an essential developmental process, contributes to intelligence and neurodegeneration at the biochemical, cellular, and physiological level. I received my BSc at UCLA and my PhD at Duke University.
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Mable Lam
Postdoctoral Scholar, Neurosurgery
Current Research and Scholarly InterestsMyelin is required for rapid nerve signaling by insulating axons to accelerate action potential propagation. Myelin-forming cells of the central nervous system, called oligodendrocytes, orchestrate one of the most complex morphological transformations in neurobiology. Each oligodendrocyte can extend multiple processes that selectively wrap axons in tens to hundreds of spiraling membrane layers, forming myelin sheaths that vary in thickness and length. Furthermore, oligodendrocytes can respond to neural activity by adding new sheaths or by changing the geometry of pre-existing sheaths to tune neural circuitry, a process known as adaptive myelination.
What are the membrane trafficking mechanisms that drive adaptive myelination in oligodendrocytes?
How can these mechanisms be stimulated to promote myelin regeneration in disease?
By using transgenic mouse models and primary oligodendrocytes, we have found that SNARE-mediated exocytosis drives membrane addition in myelin sheaths. Current research is focused on how these pathways in oligodendrocytes may be regulated during adaptive myelination.
