School of Medicine
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Sharada Kalanidhi
Director of Data Science, Biochemistry - Genome Center
Current Role at StanfordParaphrasing the mathematician Alexander Grothendieck: the essential thing is to pose problems in the right framework.
Sharada is developing a new field, Mathematical Medicine, which applies pure mathematical frameworks to genomic and multi-omic data for quantitative, personalized diagnosis. This approach explores alternatives to prevailing cohort-based statistical paradigms, particularly in complex clinical cases that have resisted standard methods.
The mathematician Mikhail Gromov has said, “This area does not yet exist. It will have to be invented.” Mathematical Medicine represents one possible construction of such an area.
This field is focused on the development of an intermediate translation layer between cohort-based statistical models and individualized multi-omic diagnosis and clinical decision-making. Without this mathematical layer, the clinical adoption of multi-omic data- particularly for complex cases- has been limited. As a result, many complex, multi-system conditions remain undiagnosed or misdiagnosed for long periods, delaying effective treatment and, in some cases, allowing disease processes to worsen.
Further information on this field, including opportunities for early philanthropic partnerships, is available at: https://mathmed-2026.web.app/
