School of Medicine
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Clinical Instructor, Pathology
BioDr. Chan is an Associate Professor of Pathology at Stanford University. She completed her MD, PhD at New York University and Anatomic Pathology residency with subspecialty Genitourinary Pathology training at University of California-San Francisco (UCSF). She is AP board-certified. Dr. Chan has been a GU attending at UCSF for the past five years where she has successfully mentored numerous trainees in projects, publications, and career planning. Dr. Chan has co-authored more than 40 peer-reviewed research publications and has a particular interest in integrating molecular testing in diagnostic pathology, as well as recognition of prostate cancer architectural patterns than can help with prognosis and treatment decision making.
Assistant Professor of Pathology and of Medicine (Quantitative Sciences)
BioI am a physician and a biostatistician. My clinical expertise is in the diagnosis of non-neoplastic kidney and liver disease (including transplantation). My research interests center on the design of observational studies and clinical trials, the analysis of observational data, and causal inference.
Greg Charville, MD, PhD
Assistant Professor of Pathology
BioDr. Charville has a special interest in the diagnosis of rare tumors that derive from bone and soft tissues, including muscle, fat, blood vessels, cartilage, and other connective tissues. He also specializes in the classification and study of diseases related to the gastrointestinal and hepatopancreatobiliary systems.
Dr. Charville particularly enjoys working alongside Stanford's excellent physicians-in-training to classify the most diagnostically challenging cases in collaboration with pathologists from around the world, bringing to bear cutting-edge techniques for comprehensive histologic and molecular characterization in each case. This experience serves as the inspiration for laboratory-based investigation of the molecular underpinnings of human disease, focusing on genetic and epigenetic mechanisms of neoplasia and the translation of these mechanistic insights into novel diagnostic and predictive biomarkers.
Lindhard Family Professor of Pediatric Cancer Biology and Professor of Pathology, Emeritus
Current Research and Scholarly InterestsThe role of oncoproteins in cancer and development; molecular and cellular biology of hematologic malignancies; targeted molecular therapies of cancer.
Maria Inmaculada Cobos Sillero
Assistant Professor of Pathology
Current Research and Scholarly InterestsOur lab uses cellular and molecular methods, single-cell technology, and quantitative histology to study human neurodegenerative diseases. Current projects include:
- Using single-cell RNA-sequencing to understand selective vulnerability and disease progression in human Alzheimer’s disease brain
- Investigating mechanisms of tau-related neurodegeneration in human brain
- Studying the neocortical and limbic systems in Diffuse Lewy Body Disease (DLBD) at the single cell level
Assistant Professor of Pathology (Pathology Research) and of Genetics
Current Research and Scholarly InterestsOur lab are developing gene-editing technologies, such as CRISPR systems for in vivo therapy, and cleavage-free techniques for large gene insertion via microbial recombinase. Our team also pioneers in single-cell tracking for cancer and immunology studies using novel CRISPR tools. To accelerate our work, we integrate AI and machine learning into these technologies, design and evolve proteins/RNAs, pushing frontiers in understanding and treating neurological and immunological disease.
Associate Professor of Pathology at the Stanford University Medical Center, Emerita
Current Research and Scholarly InterestsAs medical director of the Hematology Laboratory, my main focus is service work, including laboratory administration, bone marrow pathology, and flow cytometry interpretation. Publications arise primarily from development or evaluation of laboratory methods or collections of unusual patient cases.
Adjunct Clinical Assistant Professor, Pathology
BioHelio Costa, PhD, is a medical geneticist with expertise in oncology, medical genetics and genomics, computational biology, data science, software engineering, and product development. He is passionate about leveraging his interdisciplinary skillset to build and develop commercial-grade cancer diagnostic products and medical software that aid in patient care and clinical decision support. Currently he is Medical Director of Oncology at Natera, and an Adjunct Clinical Assistant Professor in the Department of Pathology at Stanford Medical School.
Dr. Costa's research focuses on developing and implementing new medical diagnostic genetic tests and software for use in patient care. His research group developed DNA and RNA cancer diagnostic tests currently in use at Stanford Health Care as well as developing clinical algorithms using large-scale clinical laboratory datasets and patient electronic medical records to predict patient outcomes and aid in therapeutic clinical decision support. Additionally, Dr. Costa served as a co-Investigator in the NIH Clinical Genome Resource (ClinGen) Consortium, and led the engineering and product management teams developing FDA-recognized medical software applications used by healthcare providers, researchers, and biotechnology companies to define the clinical relevance of genes and pathogenicity of mutations identified in patients.
Dr. Costa is the founding director of the Stanford Clinical Data Science Fellowship where post-doctoral fellows engage in interdisciplinary clinical research and embed in health care workflows learning, building and deploying real-world health data solutions in the Stanford Health Care system. He is currently an Attending Medical Geneticist for the Molecular Genetic Pathology Laboratory at Stanford Health Care where he previously served as an Assistant Lab Director.
Dr. Costa received his BS in Genetics from University of California at Davis, his PhD in Genetics from Stanford University School of Medicine, and his ABMGG Clinical Molecular Genetics and Genomics fellowship training from Stanford University School of Medicine.
Professor of Pathology (Clinical) and, by courtesy, of Pediatrics (Genetics)
Current Research and Scholarly Interestsscreening and diagnosis of patients with inborn errors of metabolism, including newborn screening, development of new testing methods and genotype/phenotype correlations.