School of Medicine
Showing 51-60 of 66 Results
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Carol Clayberger
Professor (Research) of Pediatrics, Emerita
Current Research and Scholarly InterestsOur group uses molecular biology, biochemistry, and cellular immunology to investigate the activation and effector function of T lymphocytes. Research in the laboratory is currently focused on three areas: granulysin, a lytic molecule expressed late (7-12 days) after T cell activation; identification of correlates of immunity in diseases such as tuberculosis; and tolerance. The long term goal of this work is to develop new ways to treat human disease.
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Harvey Cohen
Deborah E. Addicott - John A. Kriewall and Elizabeth A. Haehl Family Professor of Pediatrics, Emeritus
Current Research and Scholarly InterestsMy research interests extend from hypothesis-driven studies in biochemistry and cell biology to discovery-driven interests in proteomics and systems biology to clinical treatment of acute lymphoblastic leukemia of children, and pediatric palliative care.
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Mitchell B Cohen
Elizabeth Wood Dunlevie Professor
BioMitchell B. Cohen, M.D., is a Professor in the Department of Pediatrics in the School of Medicine. He serves as the Chief Medical Officer for Stanford Medicine Children’s Health and the Senior Associate Dean in the School of Medicine for Maternal and Child Health. From 2014-2024, he was the Katharine Reynolds Ireland Chair of Pediatrics at the University of Alabama at Birmingham and the Physician-in-Chief of Children’s of Alabama. Prior to that, he served as the Director of Gastroenterology, Hepatology and Nutrition and Vice Chair of Pediatrics at Cincinnati Children’s Hospital Medical Center.
Dr. Cohen was the founding Director of the P30 Cincinnati Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Diseases His research focused on the mechanism of action of E. coli heat stable enterotoxin, a worldwide cause of infant diarrhea. His laboratory identified that increased guanylyl cyclase (GC-C) receptors for this toxin contributed to the increased susceptibility and severity of diarrhea seen in infants. Identification of the endogenous ligands for GC-C, guanylin and uroguanylin, led to development of knockout mice and an evolving understanding of intestinal secretion and pharmacologic treatment through this ligand-receptor family. Dr. Cohen had a long-standing NIH-supported program of vaccine trials for enteric infection, including a validated human cholera challenge model which resulted in licensure of a cholera vaccine.
Dr. Cohen has held leadership positions in several professional capacities. He served as the only pediatrician on the NIH Commission on Digestive Diseases; he was chair of the Section on Growth, Development and Nutrition of the American Gastroenterological Association (AGA) and the Section on Gastroenterology, Hepatology and Nutrition (SOGHN) of the American Academy of Pediatrics; he was President of NASPGHAN, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Dr. Cohen was elected to membership in the Association of American Physicians and has received several lifetime achievement awards, including the Shwachman Award from NASPGHAN, the Saul Horowitz Jr. Award from Mt. Sinai, and the UAB Department of Pediatrics Lifetime Achievement Award. -
Ruben J Colman, MD, PhD
Instructor, Pediatrics - Gastroenterology
BioDr. Colman is a pediatric gastroenterologist and physician-scientist with an overarching goal to improve and optimize the quality of care and outcomes for children with inflammatory bowel diseases (IBD) through precision medicine approaches. His interdisciplinary team science research program focuses on making precision medicine clinically actionable through innovative solutions merging clinical pharmacology knowledge with ‘-omics’ discoveries using microbiome and metabolomics signatures. Part of this work includes translating these findings into improved clinical treat-to-target endpoints with immediate noninvasive point-of-care measures such as intestinal ultrasound.
The foundation of his current work originates from his PhD titled ‘Precision Dosing and Personalized Medicine in pediatric IBD’. During his training, Dr. Colman was also an American Gastroenterological Association (AGA) editorial fellow for Gastroenterology and he is actively involved in the committees of several professional societies including the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), the Crohn’s and Colitis Foundation and the International Bowel UltraSound (IBUS) Group. Dr. Colman is currently supported by Early Career Awards of the Thrasher Research Fund, the NASPGHAN Foundation and the Stanford Pediatrics Physician-Scientist Bridge to K Program. -
Le Cong
Assistant Professor of Pathology (Pathology Research) and of Genetics
Current Research and Scholarly InterestsOur lab develops gene-editing technologies like novel CRISPR systems and large gene insertion techniques for gene&cell therapy. We also leverages these gene-editing tools for single-cell functional screening, to probe molecular mechanisms of cancer and immunological diseases. To accelerate our work, we integrate AI and machine learning to design and evolve gene-editing proteins/RNAs in silico, pushing the frontier that bridges computational and experimental biology.
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Christopher H. Contag
Professor of Pediatrics (Neonatology), Emeritus
Current Research and Scholarly InterestsWe develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.
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David N. Cornfield
Anne T. and Robert M. Bass Professor of Pediatric Pulmonary Medicine
Current Research and Scholarly InterestsOver the past 20 years, the Cornfield Laboratory has focused upon basic, translational and clinical research, with a primary focus on lung biology. As an active clinician-scientist, delivering care to acutely and chronically ill infants and children, our lab focuses on significant clinical challenges and tried to use science to craft novel solutions to difficult clinical problems.
