School of Medicine
Showing 1-10 of 41 Results
Clinical Professor, Pediatrics - Infectious Diseases
Current Research and Scholarly InterestsThe focus of my laboratory is the immune response to viral vaccines evaluating the ontogeny of responses in infants and limitations in immunocompromised hosts. We have studied responses to an early two-dose measles immunization, one versus 2 doses of varicella immunization, and polio vaccine in preterm versus term infants. Other active areas of research include measles and varicella immunity in HIV infected individuals, and transplant recipients.
Younger Family Professor and Professor of Structural Biology
Current Research and Scholarly InterestsStructural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.
Rehnborg Farquhar Professor
Current Research and Scholarly InterestsThe role of nutrition in individual and societal health, with particular interests in: plant-based diets, differential response to low-carb vs. low-fat weight loss diets by insulin resistance status, chronic disease prevention, randomized controlled trials, human nutrition, community based studies, Community Based Participatory Research, sustainable food movement (animal rights and welfare, global warming, human labor practices), stealth health, nutrition policy, nutrition guidelines
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult-MSD) and, by courtesy, of Pediatrics (Neonatology)
Current Research and Scholarly InterestsThe advent of high dimensional flow cytometry has revolutionized our ability to study and visualize the human immune system. Our group combines high parameter mass cytometry (a.k.a Cytometry by Time of Flight Mass Spectrometry, CyTOF), with advanced bio-computational methods to study how the human immune system responds and adapts to acute physiological perturbations. The laboratory currently focuses on two clinical scenarios: surgical trauma and pregnancy.
Associate Professor of Pediatrics (Hematology/Oncology)
BioOur lab works at the interface of biotechnology, computational biology, cellular biology, and clinical medicine to develop and apply new tools for characterizing genetic variation across single cells within a tissue with unparalleled sensitivity and accuracy. We are focused on applying these technologies to study cancer clonal evolution while patients are undergoing treatment with the aim of identifying cancer clonotypes that are associated with resistance to specific drugs so as to better understand and predict treatment response. We are also applying these methods to understand how more virulent pathogens emerge from a population of bacteria or viruses with an emphasis on developing a deeper understanding of how antibiotic resistance develops.
Clinical Associate Professor, Pediatrics - Immunology and Allergy
BioMy clinic focuses on solving the molecular puzzles that underlie rare allergic and immunologic diseases to shed light on fundamental principles governing allergy, inflammation and immune system defects. My goal is to find better and safer therapies for my patients with rare diseases that include autoinflammation, autoimmunity and primary immune deficiency. It is important to highlight that every patient requires individualized therapeutic approaches based on their underlying genetic problem and the types and severity of their clinical manifestations. For some patients, a hematopoietic stem cell transplant (HSCT) is curative while for others, a targeted drug therapy, such as a biologic or small molecule agent, is most suitable. In some cases, a truly novel therapy may be required, .e.g., anti-sense oligonucleotide therapy to suppress aberrant gene splicing or adoptive cellular therapy. My passion is to provide the best personalized therapy for our patients with allergy and immunology diseases. This often requires performing very specialized functional assays and in some cases in enlisting laboratories with specific expertise or interest in particular genetic disorders.