School of Medicine
Showing 341-350 of 621 Results
-
Bruna Gomes
Assistant Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Biomedical Data Science
Current Research and Scholarly InterestsThe Gomes Lab is interested in AI agents and causal discovery methods that trace how genetic variation acts through proteins and other molecular traits to cause heart disease, and it advances promising candidate targets to experimental validation. In parallel, with support from an American Heart Association Career Development Award, the lab studies the causal protein drivers of cardiac fibrosis and develops methods to characterize myocardial tissue from routine cine MRI.
-
Juan Sebastián Gómez-Cañón
Postdoctoral Scholar, Psychiatry
BioJuan S. Gómez-Cañón is a researcher, engineer and musician from Colombia. He holds a Ph.D. in Information and Communication Technologies from the Universitat Pompeu Fabra (Barcelona, Spain). During his Ph.D., Juan researched human-centered and trustworthy machine learning methods to predict the emotions in music. His research focuses on deep learning, human-centered ML, personalization, dataset curation, and digital signal processing. Juan also holds a M.Sc. in Media Technology (Technische Universität Ilmenau, Germany), a B.Sc. in Electronics Engineering and a B.A. in Music (Universidad de los Andes, Colombia).
-
Natalia Gomez-Ospina
Assistant Professor of Pediatrics (Genetics)
Current Research and Scholarly Interests1. Genome Editing and HSPC-Based Therapeutics
Dr. Gomez-Ospina’s research focuses on developing autologous hematopoietic stem and progenitor cell therapies using CRISPR/Cas9-mediated genome editing. Her work includes targeted integration of therapeutic transgenes into genomic safe-harbor loci, optimization of editing efficiency and safety, and development of transplantation and conditioning strategies that preserve long-term engraftment. A major goal is to create reusable, mutation-agnostic therapeutic platforms that can be adapted across diseases. Her translational work also extends to GMP manufacturing, analytical development, and IND-enabling studies needed to move genome-edited HSPC products toward clinical trials.
2. Neurometabolic and Neurodegenerative Disease Therapeutics
A major area of interest is the development of definitive therapies for lysosomal storage disorders and other neurogenetic diseases, including MPS I, Gaucher disease, Krabbe disease, progranulin deficiency, and Friedreich’s ataxia. Her laboratory investigates how hematopoietic-derived cells can deliver therapeutic proteins to peripheral tissues and the central nervous system. This includes strategies to enhance microglial replacement, improve CNS engraftment, and harness myeloid cells as therapeutic vehicles. The broader objective is to establish cell-based approaches capable of treating both inherited neurometabolic disorders and more common neurodegenerative diseases.
3. Rare Disease Genetics, Functional Genomics, and Lysosome Biology
Dr. Gomez-Ospina also studies the molecular basis of rare and undiagnosed genetic disorders. Through clinical genetics, international collaborations, and the NIH Undiagnosed Diseases Network, her work contributes to novel disease-gene discovery, functional validation of candidate variants, and definition of genotype–phenotype relationships. Her laboratory also investigates lysosomal biology and develops systems-level approaches, including the Lysosome Disease Atlas, to connect lysosome-associated genes with cellular function and human phenotypes. These efforts aim to improve diagnosis while identifying new disease mechanisms and therapeutic opportunities.
For more information go to our website:
https://www.gomezospina.com/
