School of Medicine
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Charlotte D. Jacobs M.D.
Drs. Ben and A. Jess Shenson Professor in the School of Medicine, Emerita
Current Research and Scholarly InterestsClinical Interests: general oncology, sarcomas. Research Interests: clinical trials in solid tumors.
Hanlee P. Ji
Professor of Medicine (Oncology) and, by courtesy of Electrical EngineeringOn Partial Leave from 11/01/2022 To 12/31/2022
Current Research and Scholarly InterestsCancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development, cancer rearrangements, genome sequencing, big data analysis
Esther M. John
Professor (Research) of Epidemiology and Population Health and of Medicine (Oncology)
Current Research and Scholarly InterestsDr. John has extensive expertise in conducting population-based epidemiologic studies and has led as Principal Investigator multiple large-scale studies, including multi-center studies with a study site in the San Francisco Bay Area with its diverse population. Many of her studies and collaborations investigated cancer health disparities. Her research has focused on the role of modifiable lifestyle factors (e.g., body size, physical activity, diet), hormonal factors, early-life exposures, genetic variants, and gene-environment interactions; differences in risk factors by race/ethnicity, breast cancer subtypes, and prostate cancer subtypes; risk factors for familial breast cancer and second primary breast cancer, as well as prognostic factors related to survival disparities.
As Principal Investigator, Dr. John has led a number of studies conducted in the San Francisco Bay Area, including:
- the Northern California site of the Breast Cancer Family Registry, an on-going prospective multi-generational cohort of over 13,000 families established in 1995 at six international sites;
- the Northern California site of the WECARE Study that investigates risk factors for second primary breast cancer;
- the California site of the Breast Cancer Health Disparities Study that investigated genetic variability and breast cancer risk and survival in Hispanic and non-Hispanic white populations in the context of genetic admixture;
- the Breast Cancer Etiology in Minorities (BEM) Study, a pooled analysis of risk factors for breast cancer subtypes in racial/ethnic minorities;
- the San Francisco Bay Area Breast Cancer Study, a population-based case-control study in nearly 5,000 Hispanic, African American and non-Hispanic white women that investigated the role of modifiable lifestyle factors and other risk factors;
- the San Francisco Bay Area Prostate Cancer Study, a population-based case-control study of lifestyle and genetic risk factors for advanced and localized disease.
These studies collected and pooled extensive data and biospecimens and continue to support numerous ancillary studies, collaborations and international consortia and have contributed to a better understanding of cancer risk and survival in racial/ethnic minority populations.
Dr. John is also a founding PI of the LEGACY Girls Study, an on-going prospective cohort established in 2011 that investigates early life exposures in relation to pubertal development outcomes, breast tissue characteristics, and behavioral and psychosocial outcomes in the context of having a family history or breast cancer.
Clinical Assistant Professor, Medicine - Oncology
BioI grew up hiking in the Wasatch Mountains and, after completing college in Utah, I moved to Philadelphia to attend medical school at the University of Pennsylvania in 2005. After graduating in 2009, I came to Stanford for my general internal medicine internship and residency, was invited to stay as a chief resident in 2012, and then stayed again for oncology/hematology fellowship in 2013 before joining the faculty of the division of oncology in 2016. Here at Stanford I pursue my twin passions of providing excellent clinical care and mentoring the next generation of physicians.
I specialize in the care of patients who have gastrointestinal tumors, including tumors of the pancreas, large and small bowel, liver, and biliary tree. I have experience with rare GI tumors--including both intra and extra hepatic cholangiocarcinoma--and trained under Dr. Pamela Kunz, one of the country's leading experts in the care of patients with neuroendocrine tumors and have thus seen a large number of these patients, as well.
I am lucky to have a first rate medical team by my side consisting of a nurse coordinator, a nurse practitioner, and a physician assistant. We strive together to provide capable, compassionate, responsive care and make the care of our patients our highest priority.
In addition to patient care, I am a devoted medical teacher and have worked over the past five years to elevate the teaching of medicine at Stanford University, where I have taught medical students, residents, and fellows, including conducting a randomized, controlled trial hoping to optimize the way we teach communication skills to nascent physicians.
Fluent in Spanish, I have lived in both Mexico and Argentina and am comfortable in virtually all medical situations conversing fluently in Spanish without an interpreter. I especially enjoy providing care to patients who speak Spanish as a first language.