School of Medicine
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Helene Irwin Fagan Chair in Cardiology and Professor, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsStructure, function and physiology of adrenergic receptors.
Basic Life Science Research Scientist, Molecular & Cellular Physiology
Current Research and Scholarly InterestsMy research is focusing on correlating physiological changes of brain micro-circuits with resulting anatomical changes. Currently I am studying how the induction of synaptic plasticity results in a change in the number of synapses made between a pair of neurons, and whether sub-synaptic receptor localization can account for the mechanisms of certain synaptic states. I am testing two competing hypotheses: whether 1) certain subtypes of glutamate receptors are sorted based on interactions with the unique amino acid sequence of each subunit's C-terminal tail (tail-sorting model); or 2) long term potentiation/ depression results from changes in postsynaptic density and/or the volume of the postsynaptic spine (indiscriminate model). Understanding these processes will help address a variety of issues in normal and pathological brain functions, including the basic molecular and cellular mechanisms of learning and memory formation.