School of Medicine
Showing 11-20 of 23 Results
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Amanda Kirane, MD, PhD, FACS, FSSO
Assistant Professor of Surgery (General Surgery)
BioDr. Kirane is a fellowship-trained, board-certified specialist in complex general surgical oncology. She is an Assistant Professor in the Department of Surgery, Section of Surgical Oncology, at Stanford University School of Medicine. Dr. Kirane serves as Director of Cutaneous Surgical Oncology at the Stanford Cancer Center and her clinical practice focuses on the diagnosis and treatment of melanoma and other skin cancers. She partners closely with patients and families to provide the most effective treatment approach possible. For each patient, she tailors an evidence-based, personalized care plan that is innovative, comprehensive, and compassionate.
Dr. Kirane is Principal Investigator of multiple studies in melanoma and mechanisms of resistance to immunotherapy, with focus on myeloid biology. Her current interests include immune response and novel therapies in melanoma, predictive modeling of patient responses using organoid technology, and translational biomarker development. She has led research into immune therapy for earlier stage melanoma using regionally directed therapy to augment immune response in melanoma and trials in surgical care in melanoma.
The National Institutes of Health, American Society of Clinical Oncology, the Melanoma Research Alliance, and others have funded her research. She has co-authored articles on her discoveries in the Journal of Clinical Investigation, Nature Communications, Nature Genetics, Cancer Research, Journal of Surgical Oncology, Annals of Surgery, Annals of Surgical Oncology, and elsewhere. Topics include intratumoral therapy, biomarker development, macrophage biology in melanoma and immunotheraputic resistance, and patient-derived organoid modeling. Dr. Kirane has presented updates on the management of melanoma and other cancers to her peers at meetings of the American College of Surgeons, Society of Surgical Oncology, and Society for Immunotherapy in Cancer.
Dr. Kirane has earned awards for her achievements in clinical care, research, and scholarship. The Society for Immunotherapy of Cancer, Society of Surgical Oncology, Memorial Sloan Kettering Cancer Center, and other prestigious organizations have honored her work. She is a fellow of the American College of Surgeons (FACS) and Society of Surgical Oncology (FSSO). She is a member of the Society for Immunotherapy of Cancer, American Association of Cancer Research, Society for Melanoma Research, Connective Tissue Oncology Society, Association of Academic Surgeons, and Association of Women Surgeons.
She volunteers her time and expertise on behalf of the Melanoma Research Foundation, members of her community in need, STEM programs for girls, and other initiatives. She also is fellowship trained in Physician Wellness and Wellbeing and teaches somatic technique, mindfulness-based stress reduction, meditation, and breathwork. -
Varvara A. Kirchner
Associate Professor of Surgery (Abdominal Transplantation) and, by courtesy, of Pediatrics
BioDr. Kirchner completed her medical school, surgical residency and multi-organ transplant fellowship in adult and pediatric liver, pancreas, kidney transplantation and total pancreatectomy with islet auto-transplantation at the University of Minnesota. She underwent further training in living donor liver transplantation and hepatobiliary surgery at the Asan Medical Center, Seoul, South Korea. Her clinical practice involves living and deceased donor liver and kidney transplantation in adult and pediatric patients as well as total pancreatectomy with islet auto-transplantation for patients with chronic and acute recurrent pancreatitis. She currently serves as Surgical Director of the Islet Cell Auto-Transplant at Stanford Children’s and Associate Director of the Living Donor Liver Transplant Program at the Division of Abdominal Transplantation. Dr. Kirchner’s research focuses on the biology of aging, cellular and solid organ transplantation. Her specific interests are in auto-islet transplantation, iPSC-derived hepatocyte therapies and liver regeneration. Dr. Kirchner's research on the impact of donor age on generation of iPSC-derived hepatocyte-like cells is supported by the NIA K08 Faculty Development Award. She is an active member of the American Society of Transplant Surgeons and the International Liver Transplantation Society.
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Derek M. Klarin, MD
Assistant Professor of Surgery (Vascular Surgery)
On Leave from 06/01/2024 To 05/31/2025BioDr. Klarin is a fellowship-trained vascular surgeon.
For each patient, he develops a comprehensive, compassionate care plan customized to individual needs. His goal is to help each patient achieve the best possible health and quality of life.
Dr. Klarin performs the full spectrum of diagnostic and treatment procedures for cardiovascular conditions. He treats carotid disease, peripheral artery disease, abdominal aortic aneurysm, venous thromboembolism, and other vascular diseases.
To help advance his field, Dr. Klarin has conducted research. The American Heart Association, Howard Hughes Medical Institute, and other organizations have provided grants to support his studies. He also has co-patented advances in predicting and scoring risk factors for cardiovascular disease and other conditions.
He has published extensively and co-authored more than 50 articles on new techniques and technology for diagnosing and treating cardiovascular disorders. His work has appeared in the Journal of Vascular Surgery, Circulation, JAMA, Nature Medicine, and other peer-reviewed journals.
He also has made many invited presentations to his peers. He has spoken at the Vascular Research Initiatives Conference presented by the Society for Vascular Surgery, the American Heart Association Scientific Sessions, and the annual meeting of the American Society for Human Genetics. Topics include risk factors for peripheral artery disease, the benefits of ultrasound screening for abdominal aortic aneurysm, and the impact of genetic variations on cardiovascular disease.
He is a member of the Global Lipids Genetics Consortium. He is a founding member of the Abdominal Aortic Aneurysm Genetics Consortium and the Peripheral Artery Disease Genetics Consortium. He is also a candidate member of the Society for Vascular Surgery. -
Lisa Marie Knowlton, MD, MPH, FACS, FRCSC
Associate Professor of Surgery (General Surgery)
BioDr. Knowlton is an Associate Professor of Surgery and an Acute Care Surgeon whose practice encompasses trauma surgery, emergency general surgery and surgical critical care. She is an NIH and ARPA-H funded researcher whose focus is on improving access to innovative, high- quality surgical care. She obtained her medical degree at McGill University and completed her general surgery residency at the University of British Columbia in Vancouver, Canada. Her desire to understand varied healthcare systems and develop solutions for vulnerable surgical populations led her to obtain an M.P.H. at the Harvard T.H. Chan School of Public Health and complete a research fellowship at the Harvard Humanitarian Initiative. After training as a Surgical Critical Care fellow at Stanford University Medical Center, she joined the faculty as an Assistant Professor of Surgery in early 2018. She was promoted to Associate Professor in the University Medical Line in 2023. Her institutional leadership roles include serving as the Unit Based Medical Director of the Surgical Intensive Care Unit, the Associate Vice Chair of Research for the Stanford Department of Surgery, the SHC Surgical AI Lead for Early Clinical Deterioration, and the Associate Program Director for the Surgical Critical Care fellowship.
Dr. Knowlton is board certified by the American Board of Surgery and the Royal College of Physicians and Surgeons of Canada. Dr. Knowlton’s areas of clinical interest include developing safe surgical solutions for anatomic visualization in the operating room, artificial intelligence prediction tools for detection early clinical deterioration of surgery patients, optimizing the management of critically ill patients and reducing venous thromboembolism events.
Her research focuses on improving access to high-quality and high-value surgical care, merging expertise in health economics, health equity and artificial intelligence to implement surgical innovations and health policy interventions. She leads novel work with the Department of Health Care Services focused on improving healthcare utilization through emergency Medicaid programs.
Dr. Knowlton’s research lab (https://med.stanford.edu/knowlton-lab.html) is funded by the Advanced Research Projects Agency for Health (ARPA-H), the National Institute of Health (NIMHD) through R21 and R01 grants, and the California Violence Prevention Center. She has also held funding through PCORI, the Department of Defense, the American College of Surgeons (the 17th C. James Carrico Faculty Research Fellowship), and the American Association for the Surgery of Trauma (AAST).
https://surgery.stanford.edu/news2/Knowlton-ARPA-H.html
She is active in national and international professional surgical societies, and recently served as the inaugural Chair of the Associate Member Council of the AAST. Dr. Knowlton has been recognized by the Association of Women Surgeons as both a ‘Shining Star’ and ‘Breaking the Glass Ceiling’ Leadership Scholar. She is also an American College of Surgeons Health Policy Scholar. Most recently, Dr. Knowlton was also selected as the 2023-24 U.S. ambassador for the James IV Surgical Association Traveling Fellowship program, where she will travel internationally to foster clinical and research collaborations.
