School of Medicine
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Yunkyeong Lee
Postdoctoral Scholar, Endocrinology and Metabolism
BioYun is a postdoctoral research scholar in Dr. Anna Gloyn lab (Translational Genomics of Diabetes Lab). Since she joined the lab in August 2022, she has been involved in projects investigating type 2 diabetes (T2D) susceptible genes and their molecular mechanisms for pancreatic beta cell dysfunction under the mentorship of Dr. Gloyn. In particular, she is interested in how T2D effector transcripts alter the autophagy/mitophagy pathways in human pancreatic beta cells and how this may lead to beta cell failure, mitochondrial dysfunction and T2D pathology. She has been also using CRISPR knock-in genome editing in human induced pluripotent stem cell and its derivatives to reveal loss of function variant that causes transient neonatal diabetes.
During her PhD, she focused on the roles of an epigenetic regulator and its molecular machineries in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Besides, she studied the correlation between endoplasmic reticulum (ER) stress-mediated unfolded protein response (UPR) signalling and autophagy, and further their effects on various cells using some plant extracts. Her research goal is to expand our knowledge about the cellular and molecular mechanisms of T2D and explore therapeutic targets and/or strategies.
